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Biomedical subjects

G Keck

Publications and source records attributed to G Keck.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Effects of the contamination by polychlorobiphenyls (PCBs) on the growth of the Ehrlich tumor in mice (author's transl)].

The effects of a 3-month experimental contamination with a commercial mixture of PCBs, DP5 (corresponding to Aroclor 1254) have been studied on groups of 25 SWISS female mice, at levels of 0, 10, 50 and 250 ppm added at feeding. After subcutaneous injection of 0,2 ml of Ehrlich's tumoral ascites liquid, the evolution of tumors as well as the mortality level, were different in the treated groups as compared to the control group. The percentages of mortality due to tumors were the following: control (0 ppm) = 50% 10 ppm = 5% 50 ppm = 5% 250 ppm = 35% Thus, contamination by PCBs seems to have protected these mice against the Ehrlich tumor. No decrease in body weight was noted neither were differences in size or appearance of the thymus and the spleen in the treated mice; an evident liver hypertrophy was noted in all PCB treated mice.

Animals↗
PubMed1981

[Species differences in pharmaco-kinetics of chemicals. Correlations with toxicity (author's transl)].

The species differences in kinetics of drugs or toxics were studied in laboratory and domestic animals at various stages of the fate in the body: - absorption, - distribution, blood transport, binding on plasmatic proteins, tissues; placenta passage, - elimination via the kidney, bile, and diverses secretions. Since they are very important in species differences bio-transformations of chemical substances were studied separately. The toxicological or pharmacological implications of these differences were shown from a theoretical point of view (phenomena of passage through the membranes), an experimental point of view (choice of species, extrapolation from animal to man) and from the veterinary point of view.

Animals↗
PubMed1981

Fatal poisoning of sheep by Galega officinalis (French honeysuckle).

Three cases of rare acute poisonings due to Galega officinalis L. (French honeysuckle) have been recorded in France. This plant poisoning, which generally occurs in summer, is characterized by an asphyxic syndrome which leads to death within hours. A voluminous hydrothorax is observed during post mortem examination. The toxic mechanism is yet to be established.

Animals↗