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Biomedical subjects

G Lamberti

Publications and source records attributed to G Lamberti.

At least 37 records · Page 2Linked to original sources
PubMed1981

["Ultrastructural aspects of amniotic-fluid cells". A. Non-vital cells. I. Periderm-cells (author's transl)].

The surface layer of fetal epidermis in early pregnancy, the Periderm, is progressingly replaced by the final keratinization process during fifth to sixth month of gestation. Then the peridermal cells are shed into the amniotic fluid. It is still controversial, whether complete peridermal cells or just their globular protrusions are separated. Formation of mikrovilli and invaginations of plasma membrane, the numerous smaller and larger vacuoles and the cytoplasmatic meshwork of fine filaments without production of keratohyaline, are characteristics of peridermal cells, and are described in detail by electron microscopical investigations on cells suspended in the amniotic fluid, which are most likely of peridermal origin.

Amniotic Fluid↗
PubMed1981

["Ultrastructural aspects of amniotic-Fluid Cells". A. Non-vital cells. II. Keratinocytes (author's transl)].

The ultrastructural morphology of epidermal keratinocytes, which at the end of pregnancy and after shedding of vernix represent the majority of amniotic fluid cell population, is analysed by electron microscopy. Special attention is focused on the morphological characteristics of epidermal keratinization according the changes of the cell's ultrastructure during this process: The transformation of the cytoplasma into keratin, the formation of the typical cell membrane of the keratinized squamous cells, and the findings concerning the intercellular space, especially of the zones of intercellular contact - desmosomes - and their changes.

Amniotic Fluid↗
PubMed1981

["Ultrastructural aspects of amniotic-fluid cells" A. non-vital cells. iii. large squamous cells (author's transl)].

Until desquamation of vernix caseosa near the end of gestation the large, non-keratinizing squamous cells, which have their origin mostly from upper intestinal tract, vagina and urinary tract, form the majority of the population of cells in amniotic fluid. Their structure, as seen by electron microscopy is described, especially it's changes during the process of degeneration after the cell has been desquamated into amniotic fluid: dissolution or condensation of the nucleus, cytoplasmatic changes with appearance of filaments and vesicular corpuscles, and decreasing glycogen content.

Amniocentesis↗
PubMed1981

[Activation and habituation in children and adolescents with mild and severe head injury (author's transl)].

The aim of this study was to analyse the pattern of activation and habituation of youngsters with head injuries depending on the injury's gravity. Nine patients were examined with decerebration after an apallic syndrome; the control group contained ten patients with slight cerebral contusion. The complex test stimulus (optical and acoustical stimulation requiring a reaction) was a phase of a daily, continuous 4-min load with the 'Wiener Determinationsgerät' (Schuhfried). The frequency of heartbeat was registered for 4 (8) days. We analysed the physiological and psychosubjective estimation as well as the psychophysical level of measuring to obtain concrete steps for rehabilitation, depending on the possible interactions. All variables demonstrated a definite distinction between the two groups of patients. Analysis of heartbeat frequency showed that, in spite of similar initial levels of activity, 'initial sensitization' appeared only in the control group; it diminished with habituation and repetition of the stimulus. The descriptive analysis of the HR development in the form of a mathematical exponential function showed that there were three relatively consistent types of reaction: sensitization, habituation, and indifference (nonresponder). The habituation reaction was found only in the control group, indifference only in the group of apallic patients. The analysis of reciprocal action of different levels of measurings shows a certain disorder in the functional systems of the apallic patients, as described by Luria (1976). After the test stimulus the sensomotor and physiological systems do not interact optimally in comparison with patients with slight head injuries. The resulting steps for rehabilitation are discussed.

Adolescent↗
PubMed1979

[Cervical ripening in late pregnancy and at term].

Cervical ripening before labors is not an exclusively passive process by uterine contractions. On the contrary, we can find a lot of highly active processes in the cervical connective tissue with changes in metabolism of the cells leading to changes in the ground substance and the organisation and structure of collagenous fibres. We do not as yet know the trigger mechanisms of the prepartum cervical rpiening. Probably prostaglandins and relaxin are such triggering substances. At present, our new understanding of this active cervical process does not help the obstetrician. There is no laboratory test up to now. Cervical ripeness can only be examined on the basis of clinical criteria: length, consistency, position, and dilatation of the cervix uteri and station of the fetal head. The most usual score of cervical ripeness is Bishop's Pelvic-score. A high scoring excludes failures of induction of labor. But the rate of wrong prognosis, concerning efficiency of induction and time of labor is relatively high in cases with low rating of cervical ripeness. A more differentiated scoring of some of the criteria and some weighing of these seems to lead to better prognosis. On the other hand, recent clinical experiences with prostaglandins lead us to expect that we will be able to induce cervical ripeness.

Cervix Uteri↗
PubMed1978

[Modification and improvement of the diagnosis of cerebral damage (DCS) for clinical use (author's transl)].

The purpose of this study was to determine whether Weidlich's DCS Test (Diagnostikum für Cerebralschädigung) (Weidlich, 1969) which is very burdensome when applied to brain-damaged patients, could be simplified by means of multivariate error analysis without loss of its great diagnostic value. The results of 40 brain-damaged patients and 47 clinical control patients were examined by multivariate analysis. In order to establish a comparative learning-function value, a random sample of 20 nonclinical persons was tested, as well. Results showed that within a discriminant function the error variables could differentiate clinical groups just as well as Weidlich's global criterium, while a diagnosis could be established after only about half the test time. Applicability of the multivariate methods to the diagnosis of single clinical cases was confirmed by means of positive cross validation.

Adult↗
PubMed1978

[Measuring the turbidity of amniotic fluid, a possibility to assess fetal maturity before birth (author's transl)].

At the end of gestation, depending on maturation of the fetus and especially of its skin, vernix caseosa is detached into amniotic fluid. The changes of amniotic fluid turbidity can be quantitatively verified with a fotometer (filter for 578 nm, 10 mm disposable cuvettes). The turbidity of amniotic fluid was measured in 125 cases. No correlation was found between turbidity and length of gestation from day 261 to day 287 after last menstruation. In contrast, there is strong and significant contingency between turbidity of amniotic fluid and maturity of fetal skin (quantity of vernix caseosa) or clinical maturity assessed according to Farr et al. Finding a turbidity below 0.5 U on extinction scale of the fotometer, the fetus is not fully mature in 50% of these cases; placental dysfunction can be excluded with high probability. In contrast, two thirds of the children with high turbidity of amniotic fluid (more than 1.0 U on extinction scale) had clinical signs of placental dysfunction.

Amniotic Fluid↗
PubMed1977

[Intensive supervision of labor with the help of the computor (author's transl)].

A system of supervision which we developed was described. With this system it is possible to make on-line evaluations of the CTG and postpartal blood analyses from the cord blood via computors (AEG 60-10 and AEG 60-50). The computed parameters together with all obstetrical data collected during the pregnancy (results from ultrasonic tests, estrogen and HPL analyses, anamnestic data and additional "clinical findings") as well as off-line evaluated CTG findings made during the course of the pregnancy were scored. The CTG is evaluated on-line via the "cross correlation function" and can be produced in a wide variety of parameters at any time during labor. The complete system is demonstrated on the basis of an individual case analysis. The first statistical individual case analyses of deceleration in CTG were compared with the classical Hon and Caldeyro-Barcia method of calculation.

Diagnosis, Computer-Assisted↗
PubMed1977

[Study of the precision and limitations in measuring left ventricular pressure and its first time-derivative (author's transl)].

The precision in measuring left ventricular pressure and its first time-derivative has been evaluated with the study of the physical caracteristics of a system currently used for pressure wave sampling. Besides the different catheters, the set-up tested consists of a nylon connector (110 cm) and of two three way stopcocks. Amplitude and phase response, from 1 to 60 Hz, have been obtained testing the system with sinusoidal pressure waves generated by an hydraulic oscillator. Despite mild differences dependent on the different catheters, the system amplifiers remarkably at frequencies above 5 Hz. Above this limit the harmonic content of the left ventricular pressure wave is negligible and can be ignored in defining the basic morphology and the absolute values of the curve. Similary, the amplification of these high frequency harmonics operated by the system does not affect appreciably pressure measurements. In the case of the pressure time-derivative the significant harmonic content is shifted toward higher frequencies. For this reason a reliable dp/dt cannot be obtained with this hydraulic set-up. A maximal hypothetic error, utilizing a Cook 5.2 F 105 cm catheter, of 8-9% and 28-31% has been estimated for pressure and time-derivative measurments respectively.

Cardiac Catheterization↗
PubMed1975

[4-allyloxy-3-chlorophenyl-acetic acid (alclofenac) in the treatment of painful arthroses in the aged. Double-blind controlled clinical trial].

The antiarthrosic effectiveness with respect to spontaneous pain upon movement and pressure, of alclofenac (4-allyloxy-3-chlorophenyl-acetic acid) was tested in a homogeneous group of elderly patients and compared with orally administered indomethacin. The research was carried out in strictly controlled, double-blind experimental conditions. The results obtained suggest that 500 mg of the new anti-inflammatory analgesic have the same action as 25 mg of indomethacin but with a lower incidence of the side effects common to all anti-inflammatory substances. Thanks to its good tolerability and high effectiveness, the new drug should be of considerable utility in the treatment of arthrosis in the elderly and in painful, inflammatory complications.

Aged↗