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Biomedical subjects

G Lanzer

Publications and source records attributed to G Lanzer.

67 records · Page 4Linked to original sources
PubMed1980

[Clinical immunology and immunopathology of glomerulonephritis (author's transl)].

Many problems of clinical immunology with regard to glomerulonephritis become evident only when basic immunopathological principles are taken into consideration. The objective of this paper is to contribute to a deeper understanding of both clinical and immunological problems concerning glomerulonephritis and its prognosis and immunotherapy by a presentation and discussion of immunopathological processes.

Animals↗
PubMed1980

Experimental arthritis induced by granulocyte collagenase.

Purified human granulocyte collagenase (1 mg %, 10 mg % or 50 mg %) was injected into rabbit knee joints (three groups of 6 animals each) three times within one week. Synovium and synovial fluid were investigated 18 hours, 1 week and 3 weeks after the last injection. After 18 hours, synovial fluids showed distinct cellular exudation, its size depending on the amount of collagenase applied. A smaller number of cells was seen after one week, while normal cell counts were observed 3 weeks after the last injection. Histologically, synovium showed an acute arthritis after 18 hours, whereas after 1 and 3 weeks a chronic proliferative form of arthritis with predominant activation of fibroblasts was diagnosed. As compared with an experimental arthritis induced with rheumatoid synovial collagenase, granulocyte collagenase was less arthritogenic. Neither trypsin nor saline injections induced distinct cellular exudation into synovial fluids nor histologic signs of arthritis.

Animals↗
PubMed1980

[Immunotherapy II: clinical investigations for the induction and activity of interferon (author's transl)].

This contribution is concerned with the concept of immunotherapy and the search for the new therapeutic agents. Examples given are, aristolochic acid, Poly I:C and Interferon. The results show a clear correlation of in vivo and in vitro activity of Interferon in the case of virus infections (eccema vaccinatum). No certainty could be determined concerning the efficiency of A.S. and Poly I:C, determined concerning the efficiency of A.S. and Poly I:C, if an Interferon-mechanism was anticipated.

Aristolochic Acids↗
PubMed1980

Suppressor cell activity in patients with rheumatoid arthritis.

Twenty-one patients with definite or classical rheumatoid arthritis (RA) were investigated for their suppressor cell activity by a Concanavalin A suppressor cell assay. Two patients had active disease, 9 moderately active disease, and 10 inactive disease according to clinical and laboratory parameters. A mean of 41 +/- 7% suppression was observed in RA patients as compared to 63 +/- 7% suppression observed in 10 healthy age and sex matched controls. No significant difference was observed between patients with moderately active or active disease (39 +/- 9%) and patients with inactive RA (43 +/- 10%). However, a borderline statistical significance (p = 0.05) was seen between controls and patients with moderately active or active RA. Use of autologous serum instead of AB serum for suppressor cell induction had no significant effect, although an increase of the mean suppression was noted (58 +/- 6%) in patient's group. No correlations existed between suppressor cell activity and presence of circulating Clq-binding immune complexes (solid-phase Clq assay), rheumatoid factor (Waaler-Rose test) or antinuclear antibodies (indirect immunofluorescence). This study indicates that lymphocytes of patients with inactive RA exert normal suppressor cell activity. It may well be that patients with active rheumatoid arthritis have decreased suppressor cell function. This will be assessed in a larger group of patients with active disease.

Adult↗
PubMed1979

[Disturbances in granulocyte chemotaxis in patients with multiple myeloma].

a) Leukocyte chemotactic activity, b) cytotaxic activity of patients' sera and c) influence of patients' sera on chemotactic activity of control leukocytes was studied in 18 patients with multiple myeloma, one patient with monoclonal IgE-gammopathy of undetermined significance and 32 controls. Chemotactic activity of patient leukocytes against Zymosan-activated normal serum and against Casein was reduced significantly. In addition, in 66% of the patients a chemotaxis inhibiting serum factor was observed. The Zymosan-induced generation of cytotaxic factors did not differ in patients or control sera. These data show that leukocyte inherent defects as well as serum factors give rise to reduced leukocyte chemotactic activity in patients with multiple myeloma. This impairment is likely to contribute to the increased susceptibility to infections in that disorder.

Chemotaxis, Leukocyte↗
PubMed1978

[Indications and use of therapeutic component separation].

Therapeutic component separation: Clinical indications and applications. This original communication describes clinical indications, applications and results of the component separation. We have used the Hemonetics cell-separator designed for a discontinuous separation procedure. By this means component separation was rapid and plasma-exchange efficient, which offers a promising way for symptomatic treatment when a qualitative or quantitative modification of the composition of the blood is wanted (e.g. diminuation of hyperviscosity, modifications of circulating immune complexes, elimination of toxic antibodies and protein bound toxins). Component separation represents a step forward to supportive treatment and immunological reconstitution.

Antigen-Antibody Complex↗
PubMed1976

[Therapeutic plasmapheresis--a new form of adjuvant treatment (author's transl)].

We have been separating cells and plasma from the peripheral blood since 1967 for the isolation of lymphocytes and hence the preparation of ALG. Expanding the method following a therapeutic need the therapeutic plasmapheresis took its place in our clinical trials. We have carried out 210 plasmapheresis without complications. According to the clinical experience therapeutic plasmapheresis may be indicated in the following conditions: 1. some cases of intensive care patients (intoxications, metabolic disorders such as liver coma, thyreotoxicosis), 2.hyperviscosity-syndromes (plasmocytoma, macroglobulinemia), 3. immune complex diseases (e.g. systemic lupus erythematodes), 4.toxic antibody syndromes (Goodpasture-syndrome, graft rejection on the basis of HL-A-antibodies), 5.hyper-hydration and electrolyte imbalances in renal insufficiencies until hemodialysis can take place, 6. leukemias before intensive chemotherapy.

Adult↗
PubMedDate not supplied

IgA2-alveolitis and eosinophilic pneumonia--a possibly virus-triggered allergy.

A case of severe therapy-resistant asthma in a young girl with a duration of two years prior to death is reported. At autopsy antibodies of the IgA2-subtype were demonstrated in the lungs on the alveolar basement membranes. We were able to demonstrate intracellular virus-like structures by electron microscopy; this virus infection is taken to be the cause of antibody production. Following antigen-antibody reaction a non-complement-mediated eosinophilic pneumonia with numerous macrophages developed. This inflammatory reaction showed the injurious effect of eosinophilic granulocytes causing fibrinoid necrosis; this is confirmed by the pronounced depletion of the Charcot-Leyden-granules, equivalent to the release of the major basic protein and the Charcot-Leyden crystal protein. Death was caused by IgA2 deposition in the myocardial vessels with consequent eosinophilic myocarditis.

Adolescent↗
PubMedDate not supplied

Leukocyte locomotion and regulative serum effects in rheumatoid arthritis.

Leukocyte locomotion (LL) of 40 patients with rheumatoid arthritis (RA) was found to be unimpaired as compared to LL of 23 control individuals (p Greater Than 0.2). Casein and zymosan activated human sera were used as cytotaxins, and the sera of RA patients proved to be activatable in the same way as control sera in that they produced a similar chemotactic activity (p Greater Than 0.2). However, RA sera inhibited LL significantly (p Less Than 0.01) in comparison to control sera. This phenomenon was unchanged after elimination of immune complexes be ultracentrifugation, but could be reversed, after incubation of cells with RA sera, by reincubation with control sera.

Adult↗
PubMedDate not supplied

[Susceptibility for infections in patients with chronic polyarthritis].

The case histories and autopsy findings of 79 patients with rheumatoid arthritis (RA)--15 patients with and 64 patients without a history of long term corticoid treatment--who had died in the years 1952-1977 and who had been autopsied in the University Institute of Pathology of Graz were evaluated with respect to organic lesions caused by infections and were compared with an exactly matched control group. Both in the rheumatoid group material and in the 64 RA patients without steroid. long term treatment there was a highly significant accumulation of putrid bronchitis and pneumonia and a significant accumulation of pyelonephritis in comparison to the control group. As far as bronchiectases and pulmonary tuberculosis are concerned, there was an increased prevalence in the RA group, but this was beyond the range of statistical significance. Possible reasons that might account for the elevated susceptibility to infections in patients with RA are discussed.

Arthritis, Rheumatoid↗