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Biomedical subjects

G Ligny

Publications and source records attributed to G Ligny.

At least 37 records · Page 2Linked to original sources
PubMed1981

Lack of clinical and physiological relationship between gastrin and calcitonin in man.

The clinical and physiological relevance of the relationship between gastrin and calcitonin has been investigated in normal subjects and in patients suffering from gastritis or duodenal ulcer. Basal plasma levels of calcitonin are increased in these patients but there is no significant relationship between calcitonin and gastrin levels. Acute pentagastrin injection in normal male subjects increased significantly (P less than 0.05) plasma calcitonin levels whereas lower doses of pentagastrin which are known to stimulate gastric secretion are without effect on calcitonin levels. Moreover, stimulation of gastrin secretion by a protein test meal and by intragastric administration of a calcium chloride solution is not followed by any significant increase of plasma calcitonin levels. These results suggest that the stimulation of calcitonin secretion by gastrin and its synthetic analogue pentagastrin is a pharmacological rather than a physiological phenomenon.

Adult↗
PubMed1977

Relation of the acid concentration of the parietal component of the gastric juice to the maximal acid output in man.

In two populations of patients tested with S.C. histamine and with I.V. pentagastrin the values of the theoretical acid [H+]O and chloride [Cl-]O concentration of the parietal secretion for a zero value of sodium from the relationships H+ = f ([Na+]) and Cl- = f ([Na+]) were calculated. In both populations a decrease of [H+]O and [Cl-]o for low acid outputs was observed. The parallel decrease of the calculated H+ and Cl- ion concentration of the parietal component for low acid outputs gives indirect evidence that parietal secretion could become hypotonic in patients whose acid output is low.

Chlorides↗