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Biomedical subjects

G Ligny

Publications and source records attributed to G Ligny.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Interest of the association clonidine-spironolactone in cirrhotic patients with ascites and activation of sympathetic nervous system.

BACKGROUND: The aim of this study was to examine the effects of spironolactone, clonidine and the association of clonidine-spironolactone on renin-aldosterone and sympathetic systems, renal function, systemic hemodynamics and mobilization of ascites in 32 alcoholic cirrhotic patients with marked increase in sympathetic system. METHODS: Measurements were taken before and after an 8-day treatment with spironolactone (200 mg/day), after an 8-day treatment with clonidine (0.150 mg/day) and 10 days after adjunction of spironolactone (200 mg/day) to clonidine. RESULTS: Three patients abandoned the treatment or were excluded because lack of compliance. Spironolactone alone induced an increase in renin-aldosterone and sympathetic systems without any remarkable increase of natriuresis and body weight loss. Given for 8 days, clonidine alone induced a significant decrease in plasma norepinephrine associated with a significant increase in glomerular filtration rate without effect on natriuresis. In contrast, 10 days after adjunction of spironolactone to clonidine, plasma renin and aldosterone significantly decreased, natriuresis increased (from 7.4 +/- 0.7 to 41.6 +/- 3.2 mEq/24 h) and body weight decreased (from 66.03 +/- 2.3 to 63.5 +/- 2.3 kg) without adverse effects. CONCLUSION: In cirrhotic patients with ascites and marked activation of sympathetic nervous system, spironolactone (200 mg/day) is unable to mobilize ascites. In these patients, after 8 days, clonidine decreases sympathetic activity, increases glomerular filtration rate and after 18 days, decreases plasma renin and aldosterone concentrations allowing a better action of spironolactone. The association clonidine-spironolactone enhances natriuresis and body weight loss.

Adrenergic alpha-Agonists↗
PubMedDate not supplied

[Factors influencing healing of duodenal ulcer in smokers treated with cimetidine].

In 118 male patients with duodenal ulcer smoking cigarettes, treatment with cimetidine 1 g/day promoted healing of the ulcers in 67% after four weeks. No differences were observed between healed and not healed patients for age, symptom period before treatment, early onset and multiple ulcers. In not healed patients, more had a greater ulcer diameter (p less than 0.001) and more were heavy smokers (greater than 30 cig./day; p less than 0.001). In not healed patients, pentagastrin-induced maximal acid output, corrected for age, was higher than in healed patients (p less than 0.001). We confirmed the linear relationship between acid output and the number of cigarettes smoked per day (p less than 0.001). By the stepwise logistic regression model, the following factors were selected as predictors for healing of duodenal ulcer with 68% correct classification: ulcer size (p less than 0.01) and daily consumption of cigarettes (p less than 0.01). (Acta gastroenterol. Belg., 1990, 53, 299-306).

Adult↗
PubMedDate not supplied

Effect of a long term cholinergic therapy on the gastric acid secretion and on the calculated acid concentration of the parietal component in hypochlorhydric patients.

Fourteen hypochlorhydric patients suffering from atrophic gastritis were tested with pentagastrin and randomly distributed in groups treated per os : one by a placebo, the other by eserine amine oxide. In the placebo group we did not observe a variation in the acid output nor in the acid concentration of the parietal component. In the patients treated with eserine amine oxide, the acid secretion and the acid concentration of the parietal component increased on treatment (p less than 0.01). In two other groups of hypochlorhydric patients tested with pentagastrin (n = 25) or with histamine ( n = 38) and treated for periods of one to three months we also observed an increase in the acid output and the acid concentration of the parietal component. These facts could be explained by an increase in the number of functional cell units, accompanied by a qualitative variation in the parietal component during treatment the patients suffering from atrophic gastritis.

Achlorhydria↗