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Biomedical subjects

G Lundberg

Publications and source records attributed to G Lundberg.

At least 19 recordsLinked to original sources
PubMed2001

Lactate concentrations in human skeletal muscle biopsy, microdialysate and venous blood during dynamic exercise under blood flow restriction.

The intramuscular microdialysate lactate concentration during dynamic exercise with various degrees of blood flow restriction and its relation to lactate concentration in skeletal muscle biopsy and venous blood were studied. Nine healthy males performed three one-legged knee extension exercises (Ex 1-3). Blood flow was restricted stepwise by applying supra-atmospheric pressure over the working leg. Microdialysate mean (range) lactate concentrations at the end of the exercise periods were 3.2 (0.5-6.6), 4.4 (1.1-9.8) and 7.9 (1.1-11.6) mmol.l(-1)during unrestricted, moderately restricted and severely restricted blood flow respectively. There was a significant correlation between microdialysate and venous lactate concentrations at the end of all three exercise periods. Microdialysate lactate concentration correlated significantly to skeletal muscle biopsy lactate concentration at the end of Ex 1. In conclusion, microdialysate lactate concentration in the working muscle increased step-wise with increasing blood flow restriction. It showed a better correlation to venous than to muscle biopsy lactate, which is possibly partly explained by the characteristics of diffusion between body compartments and differences in time resolution between the methods used.

Adult↗
PubMed2000

Continuous assessment of local metabolism by microdialysis in critical limb ischaemia.

OBJECTIVE: to investigate the feasibility of using microdialysate glucose, lactate and pyruvate concentrations for grading the severity of blood flow reduction in patients with critical limb ischaemia. PATIENTS AND METHODS: microdialysis catheters were inserted (two subcutaneously and one intramuscularly) in the symptomatic limb of ten patients. To further reduce limb perfusion, the lower leg was elevated during part of the experiment. RESULTS: elevation reduced ankle and toe blood pressure and transcutaneous oxygen tension. Microdialysate glucose concentration decreased at all three catheter sites, while lactate increased in the intramuscular catheter. Two patients interrupted the elevated position prematurely due to severe pain in the foot. They had among the highest lactate levels in the horizontal position and the most marked increases following provocation. Neither initial metabolite concentrations nor concentration changes during elevation were shown to correlate to conventional methods used to assess limb perfusion. CONCLUSIONS: in patients with critical limb ischaemia microdialysis can be used without complications. A significant decrease in glucose concentration may reflect lowered blood flow in the elevated position. Metabolic response, i.e. increase in lactate concentration during profoundly reduced limb perfusion was heterogeneous, indicating an overestimation of the presence of ischaemia in some patients using current diagnostic methods.

Arterial Occlusive Diseases↗
PubMed2000

Correlations between joint and spinal mobility, spinal sagittal configuration, segmental mobility, segmental pain, symptoms and disabilities in female homecare personnel.

The aim of a study comprising 607 women working as homecare personnel was to investigate general spinal, joint and segmental mobility, different symptoms (pain and strain) and their relation to various aspects of disability. Joint mobility (mainly peripheral) was estimated using the "Beighton" score and spinal posture and mobility were measured by kyphometer. Passive segmental mobility and pain provocation were estimated manually. Pain intensity and strain during work and leisure were estimated using visual analogue scales for defined anatomical regions. Disability was rated using defined items and two indices. The 7-day prevalence of low back pain was 48%. Peripheral joint mobility, spinal sagittal posture and thoracic sagittal mobility showed low correlations with disability. Lumbar sagittal hypomobility was associated with higher disability. Manually estimated segmental mobility and segmental pain provocation of L4-L5 and L5-S1 correlated with disability; hypo- and hypermobility or positive pain provocation tests at these levels showed higher disability than normal mobility and negative pain provocation tests, respectively. Cluster analysis revealed that the combination of positive pain provocation tests and low lumbar sagittal mobility was associated with particularly high disability levels. In conclusion, positive pain provocation tests were clearly associated with high disability levels.

Activities of Daily Living↗
PubMed2000

Fewer women than men have positive SPECT and PET cardiac findings among patients with no history of heart disease.

UNLABELLED: A lower detection rate of coronary artery disease (CAD) has been reported for SPECT imaging in women, despite the fact that similar numbers of women and men die each year of heart disease. Ruling out instrumentation as a possible source of this low detection rate for CAD in women could be important in determining the root cause of this difference. METHODS: Patients were referred by cardiologists and randomized to PET or SPECT by the imaging center. A total of 210 patients (106 women, 104 men) were enrolled in this study, with 105 imaged by dual-isotope SPECT and 105 imaged by 82Rb PET. Rest/stress scanning was performed using dipyridamole. The effects of sex, prior history of CAD, and instrumentation on the detection of positive scans were determined using multiple logistic regression analysis with positive scans as the endpoint. RESULTS: For the total study population, sex and prior history of CAD are significantly associated with positive scans, whereas imaging modality and age are not. There was no significant interaction between sex and prior history of CAD. Men have 4.1-fold greater odds of having a positive nuclear scan than women, and patients with prior history of CAD have 5.2-fold greater odds of a positive scan after controlling for the confounding effects of age and imaging modality. In the subgroup of patients with no prior history of heart disease, men have 3.9-fold greater odds of a positive scan than women, and the odds ratio of a positive scan is 2.5-fold greater for PET than for SPECT. There was no statistical difference in the number of positive scans by SPECT or PET, or positive scans by sex in patients with documented history of CAD. CONCLUSION: Fewer women than men have positive nuclear cardiology scans by both PET and SPECT, despite similar symptoms. Instrumentation characteristics alone do not account for this sex-based difference and suggest the possibility that early CAD may present differently in women than in men.

Aged↗
PubMed1999

The relationships between spinal sagittal configuration, joint mobility, general low back mobility and segmental mobility in female homecare personnel.

The aim of this study was to investigate joint mobility, segmental and general spinal mobility and their interrelationship in 607 women working as homecare personnel. Joint mobility (mainly peripheral) was estimated using the "Beighton" score. Spinal posture and mobility were measured by Debrunner's kyphometer. Passive segmental mobility and pain provocation were estimated manually. Reliability tests between two physiotherapists of segmental mobility and pain provocation (n = 150 subjects) were performed. Positive correlations were found between joint mobility, sagittal thoraco-lumbar mobility and segmental mobility. Hyperlordosis (>39 degrees) was associated with greater lumbar mobility. The reliability of manual segmental mobility and segmental pain provocation was good, especially in the lowest back segments (kappa approximately 0.7). Joint mobility, general mobility and segmental spinal mobility intercorrelated. Segmental mobility manually estimated showed intertester reliability. The good positive correlation between sagittal lumbar mobility and manually tested segmental mobility indicates criterion validity for the latter.

Adult↗
PubMed1997

Sound quality judgment during acclimatization of hearing aid.

This study included 10 subjects with sensorineural hearing loss. They had not previously used hearing aids. The hearing aid fitting with "behind-the-ear' aids was based on the NAL method. Judging the sounds in their ordinary home environment, three sound situations (programmes) were selected, permitting the subjects to listen to one programme with speech, another with music and a third with "background noise'. For the group as a whole, significant differences were found between the sound quality judgements with and without the hearing aid. When the judgements of the programmes with background noise were excluded in the analysis, there were significant differences over time in the group as a whole on the scales for clarity and total impression.

Follow-Up Studies↗
PubMed1995

PAS-Port: a new implantable vascular access device for arm placement: experiences from the first two years.

OBJECTIVE: To evaluate the performance of a new subcutaneous infusion port for placement in the arm. DESIGN: Retrospective study. SETTING: Karolinska Hospital, Stockholm, Sweden. SUBJECTS: 85 of 90 consecutive patients referred for implantation of a subcutaneous infusion port. Five records were missing. Implantation was successful in 81 cases (95%). INTERVENTIONS: Implantation of a PAS-Port (Kabi Pharmacia Deltec) subcutaneously on the forearm. Vascular access was obtained by cut-down. MAIN OUTCOME MEASURES: Success rate, complications and reliability in routine use. RESULTS: After a follow-up time of 1-24 months (median 5), 42 ports were still in use, 21 patients had died with functioning ports, two ports had been removed at the end of treatment, 11 had been removed because of complications and because they malfunctioned; and 3 patients were lost to follow-up. The overall infection rate was 0.08/100 catheter days. CONCLUSIONS: PAS-Port is a safe alternative to chest-placed port systems where there is a need for long term vascular access in adult patients.

Adolescent↗
PubMed1992

Perceived sound quality in a hearing aid with vented and closed earmould equalized in frequency response.

Nine normal-hearing subjects listened to speech and music in a hearing aid, either through a vented earmould or a closed earmould. The complex frequency responses of the two systems were made equal by compensating the aid and closed mould combination with a digital filter. The subjects rated the perceived sound quality of the systems on seven perceptual scales and a scale for overall impression. The results of the ratings support the hypothesis that there is no difference in perceived sound quality between vented and closed earmoulds that are equalized in frequency response, provided that the perceived loudness is the same in both cases.

Acoustic Stimulation↗
PubMed1990

Perceived sound quality of reproductions with different frequency responses and sound levels.

Three programs (female voice, jazz music, and pink noise) were reproduced using four different frequency responses and two different sound levels. Fourteen normal hearing subjects listened to the reproduction via earphones and judged the sound quality on seven perceptual scales (loudness, clarity, fullness, spaciousness, brightness, softness/gentleness, and nearness) and a fidelity scale. Significant differences among the reproductions appeared in all scales and could be attributed to the differences in frequency response or sound level or both. Interactions between the reproductions and the programs could be explained by the relations between the spectrum of the programs and the frequency responses used. The results for the noise program were similar to those for the jazz music program.

Adult↗
PubMed1984

A simplified evaluation of vital capillary microscopy for predicting skin viability in patients with severe arterial insufficiency.

In the present study the predictive value of a simplified VCM (Vital Capillary Microscopy) classification in assessing the development of skin necrosis was investigated in 69 patients with severe peripheral arterial obliterative disease (AOD) of the leg. The arterial circulation of the foot was evaluated by systolic blood pressure (SBPt). The structure and blood filling of the skin capillaries of all toes and forefeet were evaluated by an ordinary stereo-microscope at a magnification of 10 to 40 times. A three stage classification was used for evaluating the nutritive skin capillaries: Stage A, B and C. The individual patient was classified according to the worst stage found in the foot. The predictive value for the SBPt measurements with regard to the development of skin necrosis was for the best group (21-30 mmHg) 6%, for the middle group (11-20 mmHg) 58% and for the worst group (0-10 mmHg) 56%. The predictive values for the VCM Stages A, B and C were 5, 16 and 93% respectively. The sensitivity with the borderline between Stage A and B + C was 97% and the specificity 53%. With the borderline between stage A + B and C the sensitivity and specificity became 87% and 95% respectively. It may be concluded that the VCM classification with three stages used in the present study seems to be very useful for predicting the risk of skin necrosis in patients with severe AOD.

Adult↗