[The chief--methods of selection, demands and problems of utilization].
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Authoritarianism↗
Biomedical subjects
G Lundberg
Publications and source records attributed to G Lundberg.
[Stress in the administrative organization].
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Administrative Personnel↗
A rat model for severe limb ischemia at rest.
We sought an animal model able to discriminate metabolic and angiogenic processes in limb ischemia. For that we modified and evaluated a rat model of severe unilateral limb ischemia at rest. A two-stage surgical procedure entailing left femoral artery ligation preceded by interruption of collateral vessels originating from the infra-renal aorta and left iliac arteries was performed in Sprague-Dawley rats. The model was evaluated for up to 8 weeks with a transit-time flow meter, a laser Doppler perfusion imager, microspheres, arteriography and histology. It was found to be well tolerated with low mortality and perfusion in the foot skin was reduced up to 8 weeks, while collaterals were visible after 2 weeks. Histologic signs of ischemia were seen for up to 4 weeks. This rat model of severe limb ischemia at rest lasts up to 8 weeks and seems well suited for longitudinal studies of the pathophysiology of limb ischemia and healing mechanisms like angio- and arteriogenesis.
Angiography↗
Looking back, looking forward: straight talk about U.S. medicine. Interview by Fitzhugh Mullan.
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Academic Medical Centers↗
Uniform requirements for manuscripts submitted to biomedical journals. International Committee of Medical Journal Editors.
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Canada↗