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Biomedical subjects

G M Aber

Publications and source records attributed to G M Aber.

At least 37 records · Page 2Linked to original sources
PubMed1982

Circulating immune complexes in cutaneous and systemic vasculitis: clinicopathological correlations.

A high incidence of raised levels of circulating immune complexes has found in a group of patients with idiopathic vasculitis. Serial measurements in 8 patients with systemic vasculitis showed a good correlation between clinical status and circulating immune complex levels. Some correlation existed between the constituents of circulating and tissue-bound complexes in 6 patients so studied. However, there was no correlation between apparent organ involvement and hypocomplementaemia and the levels of size of circulating immune complexes. It is concluded that the measurement of circulating immune complexes may be clinically useful in vasculitis, but that no direct evidence is yet available that they are pathogenetically related to those which are tissue-bound.

Antigen-Antibody Complex↗
PubMed1982

Interrelations between cerebrospinal fluid and plasma inorganic ions and glucose in patients with chronic renal failure.

The concentrations of inorganic ions and glucose in the plasma and CSF of 11 patients with "steady-state" chronic renal failure have been measured and their CSF: plasma interrelations studied. The results have been compared with the corresponding data from 34 control subjects. In the patients with renal failure, there was a positive correlation between raised CSF and plasma potassium concentrations. In contrast to the impaired potassium homeostasis, normal CSF magnesium and calcium concentrations were observed despite wide variations in the plasma concentrations of these ions.

Adolescent↗
PubMed1981

Abnormalities of cerebrospinal fluid amino acids in patients with the Guillain-Barré syndrome.

Measurements of cerebrospinal fluid (CSF) and plasma amino acid concentrations have been made in 12 patients with the Guillain-Barré syndrome. The CSF protein concentration was normal in seven specimens and raised in 13. Abnormalities of the CSF amino acid profile were found in all specimens but were more marked in those with a raised CSF protein concentration. The possible causes and diagnostic significance of these changes are discussed.

Adult↗
PubMed1981

Cerebrospinal fluid amino acid concentrations in patients with viral and tuberculous meningitis.

Serial measurements have been made of the cerebrospinal fluid and plasma amino acid concentrations in 11 patients with viral meningitis and in four with tuberculous meningitis. A small increase in the concentrations of a few amino acids in cerebrospinal fluid has been found in a viral meningitis in contrast to a marked increase in most amino acids in tuberculous meningitis. The findings are compared with those found in patients with purulent meningitis and the possible causes and the diagnostic significance of these findings are discussed.

Adolescent↗
PubMed1980

Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility.

26 patients with systemic lupus erythematosus (SLE) induced by treatment with the antihypertensive drug hydralazine were investigated to determine if predisposition to the toxic effect was associated with an HLA-DR antigen. 25 of the 26 patients were slow acetylators. The group was compared with three others (1) 113 healthy subjects, untested for acetylator phenotype, (2) 16 slow-acetylator hypertensive patients treated with hydralazine for more than a year without developing SLE, and (3) 20 patients with idiopathic SLE. The frequency of HLA-DR4 (73%) was significantly higher in the group with hydralazine-induced SLE than in the other groups (respectively 33%, 25%, and 25%). The ratio of women to men affected was 4:1. If the slow acetylators treated with hydralazine were analysed as one group, it was observed that all women with DR4 developed hydralazine-induced SLE; the only men to do so were those with DR2 who were receiving 200 mg hydralazine per day. These observations have led us to suggest guide lines for hydralazine therapy and point to a striking association between an HLA-DR antigen and an adverse reaction to a therapeutic agent. It was also noted that the distribution of DR antigens in the hydralazine-SLE patients was significantly different from that in the group with idiopathic SLE. This supports the view that the syndromes are separate entities.

Acetylation↗
PubMed1980

Persistent abnormalities of fibrinolytic activity and platelet function in patients with reversible oestrogen-associated hypertension.

Normotensive women with a previous history of oestrogen-associated hypertension were found to have raised platelet factor 3 (PF3) availability, raised triglycerides and pre-beta-lipoprotein and impaired fibrinolytic activity and capacity, but were shown to have normal platelet lifespan and renal platelet localization. The significance of these abnormalities in relation to the development of hypertension and to the intrarenal vascular disease found in these patients is discussed.

Adult↗
PubMed1980

Exaggerated natriuresis in normotensive subjects with a previous history of pregnancy-associated hypertension.

The effect of an isotonic saline infusion on urinary sodium excretion and plasma renin activity (PRA) has been studied in 11 normotensive patients with a previous history of pregnancy-associated hypertension. The results have been compared with a group of controls matched for age, sex and parity. The results demonstrate an exaggerated natriuresis and a suppressed PRA response in the patients with a previous history or pregnancy-associated hypertension which is similar to those reported in patients with established 'essential' hypertension.

Adolescent↗
PubMed1980

Dissociated renin-aldosterone response to acute sodium depletion in patients with a previous history of pregnancy-associated hypertension.

The effect of sodium depletion on body weight, plasma renin activity (PRA) and plasma aldosterone concentration has been studied in 10 normotensive subjects with a previous history of pregnancy-associated hypertension. The results demonstrate an appropriate increase in PRA but a suppression of plasma aldosterone response to this form of acute sodium depletion. The significance of this dissociated renin-aldosterone response is discussed.

Adolescent↗
PubMed1979

Studies of cerebrospinal fluid and plasma amino acids in patients with steady-state chronic renal failure.

The concentration of free amino acids in the plasma and lumbar CSF of 11 patients with steady-state chronic renal failure has been measured and the CSF: plasma concentration ratios calculated. The results have been compared with the corresponding data from 37 control subjects. In renal failure, elevation of the mean plasma concentration of total amino acids and a reduction in the ratio of essential to total amino acids have been found. Whereas some individual plasma amino acid concentrations in renal failure were higher than normal, others were lower. Striking abnormalities of the CSF amino acid concentration have been observed. Some amino acids have shown similar patterns of abnormality in both CSF and plasma, whereas in the case of others, the changes have been restricted to either CSF or plasma. Significant variations from normal of the CSF: plasma concentration ratios were observed for four amino acids.

Adult↗
PubMed1979

The effect of haemodialysis on cerebrospinal fluid and plasma amino acids.

The concentration of free amino acids in CSF and plasma has been measured in 19 patients with renal disease undergoing haemodialysis therapy. The values obtained have been compared with those measured in non-haemodialysed patients. At the end of a 10-h dialysis period, the total CSF amino acid concentration had fallen by only 23.3% compared with a 57.7% fall in plasma. Examination of the results for individual amino acid concentrations showed 3 different patterns of inter-relationship between plasma and CSF.

Adult↗
PubMed1979

Pregnancy-associated disease of the renal microcirculation.

1. Platelet factor 3, platelet survival, renal platelet localization and fibrinolytic activity have been studied in normotensive subjects with a previous history of pregnancy-associated hypertension. Studies were carried out up to 6 years after the complicated pregnancy. 2. Renal platelet localization was found to be significantly increased despite normal platelet survival and platelet factor 3 availability. Significant impairment of both resting and post-venous-occlusion fibrinolytic activity was also demonstrable. 3. The significance of these findings in relation to mediation of progressive intrarenal vascular disease is discussed.

Adult↗
PubMed1979

The relationship between the 'idiopathic oedema syndrome' and subclinical hypothyroidism.

Thyroid function has been studied in eleven patients with the 'idiopathic oedema syndrome'. Six patients have been shown to have subclinical hypothyroidism associated with the presence of thyroid antibodies. All responded to treatment with sodium thyroxine. Five patients had normal thyroid function, absence of thyroid antibodies and failed to respond to treatment with sodium thyroxine.

Adult↗
PubMed1979

Abnormalities of cerebrospinal fluid amino-acids in purulent meningitis.

Serial measurements were made of the cerebrospinal fluid and plasma amino-acid concentrations in 12 patients with purulent meningitis. Marked increases in the concentrations of most CSF amino-acids were found, possibly caused by altered transport mechanisms in the inflamed meninges and choroid plexuses.

Amino Acids↗
PubMed1979

The pathology of intrarenal vascular lesions associated with the loin-pain-haematuria syndrome.

The histological appearances of the proximal and peripheral intrarenal arteries and renal cortex have been examined in 3 patients who underwent nephrectomy for intractable pain associated with the loin-pain-haematuria syndrome. Marked 'atherosclerotic' changes were noted to involve segmental, lobar, interlobar and arcuate arteries with evidence in one kidney of early microaneurysmal formation. These lesions of the more proximal intrarenal arteries were associated with occlusive lesions of the interlobular arteries, areas of cortical ischaemia and cortical infarcts consistent with the changes resulting from microemboli. The histological appearances correlated well with previously described angiographic findings.

Adult↗
PubMed1979

Structural and functional changes in the renal circulation after complicated pregnancy.

Angiographic and histological studies of the intrarenal circulation have been undertaken in 20 patients following complicated pregnancies: 12 patients had had hypertension of pregnancy (group 1); 7 acute renal failure due to either ante- or post-partum haemorrhage and 1 patient post-partum renal failure (group 2). 3 months after delivery all patients had angiographic evidence of structural and functional abnormalities involving intrarenal blood vessels and cortical blood flow. The severity of the structural changes was related to the degree of microangiopathic haemolytic anaemia noted in the acute obstetric complication but not to the height of the blood pressure at this stage. Histological abnormalities of the cortical blood vessels were minimal. At the time of the renal angiogram and biopsy, 3 of the 12 group 1 patients were hypertensive and 3 had impaired renal function, compared with 5 and 1, respectively, in the 8 group 2 patients. Although during the follow-up period (mean 5 years) no further deterioration in renal function in either group has been observed, hypertension developed in 50% of the group 1 patients compared with only 1 of the patients in group 2. The relationship between the late onset of hypertension and the intrarenal vascular and haemodynamic abnormalities is discussed.

Acute Kidney Injury↗
PubMed1979

Cyclophosphamide alone in the treatment of adult patients with minimal change glomerulonephritis.

Eight adult patients with the nephrotic syndrome due to "minimal change" glomerulonephritis have been treated with cyclophosphamide alone. The effects of therapy have been compared with a similar group of patients treated with conventional diuretic therapy. Complete remission was achieved in seven of the cyclophosphamide treated patients as compared to only two spontaneous remissions in the untreated group. After a mean follow up period of 6 years none of these 9 patients relapsed. The eighth patient treated with cyclophosphamide remitted spontaneously 21 months after stopping cyclophosphamide and relapsed 36 months later. No serious side effects were encountered in the treated patients. The results suggest that cyclophosphamide is an effective agent in the management of adults with the nephrotic syndrome due to "minimal change" glomerulonephritis.

Adolescent↗
PubMed1977

Oestrogen-associated disease of the renal microcirculation.

The effect of oestrogen-containing compounds on platelet factor 3, platelet life span, renal platelet localization and the fibrinolytic activity of forearm venous blood has been studied in eleven women with the renal vascular abnormalities of the loin pain and haematuria syndrome. The results were compared with those obtained in twenty-nine healthy female volunteer subjects. 2. Platelet factor 3 (PF3) availability was found to be increased in patients with the loin pain and haematuria syndrome during normal menstrual cycles. Oestrogens produced an increase in PF3 availability in both patients and control subjects. 3. Platelet life span was shortened and the index of renal platelet localization increased when patients with the loin pain and haematuria syndrome received oestrogens. No change in platelet kinetics was found in the healthy control subjects receiving oestrogens. 4. The fibrinolytic activity of forearm venous blood, both at rest and after venous occlusion, was increased in the healthy control subjects in response to oestrogens. No such response was seen in the patients with the loin pain and haematuria syndrome. 5. It is suggested that the change in platelet function may be causally related to the intrarenal vascular abnormalities. 6. The possible role of oestrogens in causing these disturbances or unmasking pre-existing abnormalities of platelet function or fibrinolysis is discussed.

Adult↗