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Biomedical subjects

G M Iakovlev

Publications and source records attributed to G M Iakovlev.

70 records · Page 4Linked to original sources
PubMedDate not supplied

[Organization and methodology of the process of examinations in internal diseases in higher education].

The authors developed a system for examinations at the stage of postgraduate advanced training for therapists which included fundamental and practical classes. Fundamental classes are presented with certain tests with regard to the curriculum while the practical ones are based on the evaluation of professional clinical skill demonstrated at the examination of the patient. The developed system is realized with the help of computerized programmes CM-4. High objectivity and the wide spectrum of the programme evidence the practicability of the methods developed in the evaluation of knowledge in therapists.

Curriculum↗
PubMedDate not supplied

[The experimental anti-arrhythmia properties of the histamine H1 receptor blockader fencarol].

Phencarol, a blocker of H1-histamine receptors, is used as an antihistaminic agent. The antiarrhythmic effect of phencarol was detected and studied on experimental models of arrhythmias in non-anesthetized rabbits in a dose of 5 mg/kg intravenously. The drug was shown to possess the pronounced antiarrhythmic and protective properties on the models of calcium-chloride-, adrenaline- and strophanthine-induced arrhythmias and to exert no influence on aconitine-induced arrhythmia. Phencarol was demonstrated to have no cardiodepressive effect.

Animals↗
PubMedDate not supplied

[Intracellular metabolism in patients with insulin-dependent and non-insulin-dependent diabetes mellitus].

Slow infusion of neutral insulin causes in patients with insulin dependent and noninsulin dependent diabetes mellitus diverse changes in the levels of cAMP, cGMP and the cAMP/cGMP ratio in leukocytes in spite of one-type changes in the concentration of contrainsular hormones in the venous blood: in patients with noninsulin dependent DM a raised cAMP/cGMP factor was lowered whereas in patients with insulin dependent DM it was increased. The authors put forward for discussion the problem of the postreceptor mechanisms of tissue insulin resistance in noninsulin dependent DM and a possibility of the use of the above indices for differential diagnosis of DM types.

Adolescent↗
PubMedDate not supplied

[Use of autoblood photomodification in combined therapy of patients with diabetes mellitus of the non-insulin-dependent type].

The paper is concerned with the results of a study of the effect of single reinfusion of photomodified autoblood on the level of plasma hormones, lipid peroxidation and antioxidant system of erythrocytes, the activity of the main enzymes of glucose metabolism in erythrocytes, the state of cellular immunity in 45 patients with non-insulin-dependent diabetes mellitus (NIDDM) in 1.7 and 14 days after autoblood photomodification (BPM). BPM was shown to cause a prolonged effect of the activation of intracellular glucose metabolism, a decrease in the endogenous insulin consumption by tissues, and a decrease in the blood concentration of hormones of contrainsular action. The use of BPM enhanced lipid peroxidation and the activity of the antioxidant system of erythrocytes. Higher activity of immunocompetent lymphocytes was in line with the time course of the hormone level. The authors proposed a hypothesis accounting for a many-sided effect of BPM on glucose metabolism and hormonal changes in NIDDM patients.

Adult↗