Biomedical subjects

G Mossböck

Publications and source records attributed to G Mossböck.

3 recordsLinked to original sources

PubMed2006

[Glaucoma and oxidative stress. Determination of malondialdehyde--a product of lipid peroxidation].

BACKGROUND: Primary open-angle glaucoma (POAG) is a multifactorial disease, in which aging, race, genetic disposition, vascular status, probably inflammation, and maybe oxidative stress may play a specific role. We wanted to know if by using a common test for a specific oxidative stress product differences would be found in the aqueous humor and serum of patients with POAG, cataract without pseudoexfoliation, cataract with pseudoexfoliation, and volunteers without ocular disease. PATIENTS AND METHODS: We examined the aqueous humor of 33 patients with POAG, 111 patients with cataract without pseudoexfoliation, 39 patients with cataract and pseudoexfoliation syndrome and the serum of all three groups plus of 43 volunteers without ocular disease. Malondialdehyde as an oxidative stress product of peroxidation of lipids was proven by thiobarbituric acid-reacting substances (TBARS). RESULTS: The amount of TBARS is given in micromol/l: (1) in the serum of the group with cataract 1.176, with cataract and pseudoexfoliation 1.019, with POAG 0.992, and with healthy eyes 0.983; (2) in the aqueous humor of the group with cataract 0.279, with cataract and pseudoexfoliation 0.274, and with POAG 0.298. There were no statistically significant differences of TBARS (p<0.05) in either the aqueous humor or in the serum of patients with POAG in comparison to those patients without POAG. However, there was a significantly positive correlation between the values in the serum and the aqueous humor. CONCLUSION: For the first time malondialdehyde as a product of lipid peroxidation was determined in the aqueous humor of glaucomatous eyes. With the TBARS method used in our study, it was not possible to detect statistically significant differences of the lipid peroxidation product malondialdehyde between patients with or without POAG. It has to be taken into account that the cataract of the patients in the control group might be a disease per se caused by at least a certain amount of oxidative stress and that these subjects might therefore not be ideal as a control group.

Adult↗

PubMed2005

TNF-alpha promoter polymorphisms and primary open-angle glaucoma.

PURPOSE: Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy with a strong hereditary component. Recent studies suggested a role for tumour necrosis factor-alpha(TNF-alpha) in the pathogenesis of POAG. The purpose of the present study was to investigate a hypothesized association between the TNF-alpha-308G>A and -238G>A gene polymorphisms and the presence of POAG in a Caucasian population. METHODS: The present case-control study comprised 114 unrelated patients with POAG and 228 healthy control subjects, matched for age and gender. Genotyping of the TNF-alpha-308G>A and -238G>A polymorphisms was performed using polymerase chain reaction. RESULTS: Allelic frequencies and genotype distributions of both the TNF-alpha-308G>A and -238G>A gene polymorphisms did not significantly differ between patients with POAG and control subjects. Presence of the TNF-alpha-308A-allele was associated with an odds ratio (OR) of 0.96 for POAG, whereas an OR of 0.52 was found among carriers of the TNF-alpha-238A-allele. CONCLUSION: Our data suggest that none of the investigated TNF-alphagene polymorphisms is a major risk factor among Caucasian patients with POAG.

Aged↗

PubMed2005

[Transpupillary thermotherapy (TTT) for uveal melanomas. Long term results of a single TTT with an adapter for a conventional infrared laser].

BACKGROUND: An increasing number of orbital recurrences after TTT have been reported; the aim of our paper was to present our long-term results after a maximum follow-up of 8 years and 2 months. PATIENTS AND METHOD: Among 18 eyes, 10 tumors were classified as small, and 8 as medium sized (with a maximum prominence of 5.6 mm): 5 melanomas had a juxtapapillary location, 6 a macular (or juxtamacular) location, and 7 were located in the midperiphery of the fundus. RESULTS: After a median follow-up of 7 years in seven tumors a complete regression (scar formation) could be achieved, and in six a partial regression (with a maximum residual prominence of 2.9 mm) could be seen. In three patients a recurrence was treated either by another TTT or a Ruthenium-106 plaque; in another two recurrences, enucleation had to be performed. In none of the cases has an orbital recurrence occurred so far. CONCLUSION: To prevent recurrences, adequate technique and appropriate selection of patients are mandatory in our opinion (no tumors higher than 3 mm). The higher the tumor prominence, the greater the chance of recurrences. Amelanotic melanomas and macular melanomas seem to respond poorly to thermotherapy.

Adult↗