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TNF-alpha promoter polymorphisms and primary open-angle glaucoma.

G Mossböck·M Weger·M Moray·W Renner·E M Haller-Schober·D Mattes·O Schmut·B Wegscheider·Y El-Shabrawi
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Abstract

PURPOSE: Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy with a strong hereditary component. Recent studies suggested a role for tumour necrosis factor-alpha(TNF-alpha) in the pathogenesis of POAG. The purpose of the present study was to investigate a hypothesized association between the TNF-alpha-308G>A and -238G>A gene polymorphisms and the presence of POAG in a Caucasian population. METHODS: The present case-control study comprised 114 unrelated patients with POAG and 228 healthy control subjects, matched for age and gender. Genotyping of the TNF-alpha-308G>A and -238G>A polymorphisms was performed using polymerase chain reaction. RESULTS: Allelic frequencies and genotype distributions of both the TNF-alpha-308G>A and -238G>A gene polymorphisms did not significantly differ between patients with POAG and control subjects. Presence of the TNF-alpha-308A-allele was associated with an odds ratio (OR) of 0.96 for POAG, whereas an OR of 0.52 was found among carriers of the TNF-alpha-238A-allele. CONCLUSION: Our data suggest that none of the investigated TNF-alphagene polymorphisms is a major risk factor among Caucasian patients with POAG.

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AgedAged, 80 and overCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeGlaucoma, Open-AngleHumansMaleMiddle AgedPolymerase Chain ReactionPolymorphism, GeneticPromoter Regions, GeneticTumor Necrosis Factor-alphaJournal Article

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G Mossböck, M Weger, M Moray, W Renner, E M Haller-Schober, D Mattes, O Schmut, B Wegscheider, Y El-Shabrawi. 2005-09-02. TNF-alpha promoter polymorphisms and primary open-angle glaucoma.. https://doi.org/10.1038/sj.eye.6702078

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