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Biomedical subjects

G N Berchenko

Publications and source records attributed to G N Berchenko.

At least 19 recordsLinked to original sources
PubMed1991

[The biomechanical prerequisites and experimental validation of an arthroplastic method after the "rolling joint" principle].

The authors have proposed the idea of joint motion realization by means of rolling of one joint surface over the other one. It allows to pass over an unsolved yet problem of cartilage restoration and normal gliding in the affected joint. It has been developed a model at the knee joint of a dog, which provides for resection of the joint surfaces according to semicylinder and plane shape and introduction of lavsane bands to hold and direct movement of the articular ends. 34 dogs have been subjected to experimental operations. There was achieved good and satisfactory joint and limb function with 25 of them. Biomechanical investigation allowed to prove joint mobility and limb supporting ability.

Animals↗
PubMed1987

[Quantitative characteristics of changes in the cellular composition and vascularization of aseptic wounds in rat skin, healing without treatment and during stimulation of repair processes by exogenous collagen].

The changes in cellular composition and vascularization of aseptic wounds on the rat skin were assessed quantitatively using the ocular net without treatment and during stimulation of repair processes by exogenous collagen. An intensive increase in the number of macrophages, endotheliocytes and fibroblasts was observed in wounds without treatment by the fifth day, with maximum vascularization of the granulation tissue occurring by the seventh day. During stimulation of repair processes by collagen the macrophage reaction, proliferation of endotheliocytes and fibroblasts and vascularization of wounds were activated earlier, while the stereotype relationships of the cellular components remained unchanged. The intercellular relationships of the wound healing process are discussed.

Animals↗
PubMed1986

[Treatment of suppurative wounds of soft tissues with colocyl and its combination with proteolytic enzymes].

The effect of a collagenous preparation Colocyl and its combination with proteolytic enzymes on the healing of soft tissue purulent wounds were studied in 239 patients. Colocyl and its combination with proteolytic enzymes were shown to facilitate the rejection of devitalized tissues, control of the inflammation and activation of reparative processes.

Anti-Infective Agents, Local↗
PubMed1985

[Features of the healing of suppurative wounds in patients undergoing treatment with collagen preparations (histochemical and electron-microscopic study)].

The dynamics of purulent wound healing developing in patients surgically treated for phlegmons or abscesses was studied histochemically and electron microscopically on the material of successive biopsies. It was shown that purulent wound healing is characterized by the desynchronization of inflammation and regeneration associated with the reduced macrophagal response and disturbances of the microcirculation system. Collagen sponge reduces inflammatory changes, activates the macrophage reaction, restores intercellular interactions, normalizes the microcirculation system, enhances proliferation and differentiation of fibroblasts, collagen synthesis and secretion, processes of fibrillogenesis, maturation of granulation tissue, epithelialization.

Abscess↗
PubMed1984

[Low-frequency ultrasonics in the treatment of trophic ulcers].

The treatment of trophic ulcers by the low-frequency ultrasound results in destruction of the collagen fibres of the fibro-cicatricial tissue, reduces the bacterial dissemination, stimulates the growth of a new granulation tissue which allows to fulfill autodermoplasty .

Administration, Topical↗
PubMed1984

[Effect of low-frequency ultrasound on the course of the wound process].

By the methods of clinical and morphological investigations as well as by measurements of the wound medium pH it was established that the application of low-frequency ultrasound for the treatment of purulent wounds accelerated necrolysis, decreased bacterial contamination of the wound, normalised the microcirculation system, activated the macrophagal reaction, increased the proliferative and synthetic activity of fibroblasts, collagen fibrillogenesis and contributed to a sharp shortening of the hydratation phase which resulted in the earlier closing of the wound.

Adolescent↗
PubMed1984

[Granulation tissue: inflammation and regeneration].

Healing of the external defects by the primary tension, under the scab, or by the secondary tension through the suppuration as well as the formation of granulation tissue (GT) in other organs, represent an adequate homeostatic response to the injury with stereotype kinetics of the inflammation and regeneration. The altered general and local responsiveness trophic disorders, burn and radiation trauma result in collapse of the autoregulatory mechanisms, pronounced disturbance of phagocytosis, microcirculation, mediator and contact cell interaction. This provokes the inhibition of fibroblast proliferation, depression and perversion of fibrillogenesis and the granulation tissue maturation, the formation of abnormal granulation tissue with repeated wakes of sclerosis, necrosis and inflammation, formation of persisting wounds, ulcers, hypergranulations or chronic inflammatory processes. Homeostatic protective response transforms into the pathologic response due to dissociation between the inflammation and regeneration and formation of "vicious circle".

Granulation Tissue↗
PubMed1978

[Fibroblasts and the development of the connective tissue: ultrastructural aspects of biosynthesis, fibrillogenesis and catabolism of collagen].

According to the ultrastructural features, 6 types of fibroblasts are distinguished of which two are immature forms (little-differentiated and young fibroblasts) and the rest (collagenoblasts, myofibroblasts, fibroclasts, fibrocytes) are mature cells with the functional specificity participating in the collagen production, contraction, remodeling, involution and stabilization of the connective tissue, respectively. In their turn, collagenoblasts differ from each other in the intensity of biosynthesis and the mode of collagen secretion from the cell. Fibroblasts also produce proteoglycans which are important in fibrillogenesis. Proteoglycans form cuffing around each collagen fibril as well as are components of microfibrils and floccular material which form the ultrastructural basis of the cementating substance. A system of collagen-lytic enzymes and ultrastructural signs of collagen resorption have been found in fibroblasts attesting to their role in the maintenance of equilibrium between biosynthesis and catabolism of collagen under normal and pathological conditions.

Animals↗
PubMed1977

[Macrophage-fibroblast interaction and its possible role in regulating collagen metabolism during wound healing].

The role of macrophages in the resorption of denatured collagen in the wound tissue was demonstrated by transmission and scanning electron microscopy investigation. Tight cell contacts between the macrophages and fibroblasts in the granulation tissue preceded active collagen synthesis and fibrillogenesis. A hypothesis was suggested according to which these contacts played an important role in the transfer of specific signals for the initiation of collagen biosynthesis; collagen decomposition products were considered as the actual signals, thus connecting the collagen catabolism and biosynthesis. Such a feed-back mechanism probably served as an integral part of the general hemostasis regulating the growth of connective tissue.

Animals↗