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G N Berchenko

Publications and source records attributed to G N Berchenko.

22 records · Page 2Linked to original sources
PubMed1977

[Wound healing as an autoregulatory process].

A hypothesis of autoregulation of the reparative growth of the connective tissue based on the inverse relationship between degradation and collagen biosynthesis is suggested. At the ultrastructural level such homeostatic mechanism is realized in two stages: (1) resorption by macrophages of collagenic fibrillae of the tissue necrotized as a result of trauma and inflammation, induction of collagen genesis by cell contacts between macrophages and fibroblasts, enhanced fibrillogenesis; (2) the inhibiting effect of collagen fibers of a mature tissue contacting with fibroblasts on collagen biosynthesis with simultaneous induction of fibroclasia.

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PubMedDate not supplied

[Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil].

Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts.

Animals↗
PubMedDate not supplied

[Dynamics of nucleic acid synthesis in the granulation tissue of skin wounds in the rat].

Dynamics of nucleic acid synthesis was studied in granulation tissue, harvested within 2-11 days after an injury of rats with full-layer skin wounds, simultaneously with evaluation of the morphometric patterns of the tissue. Synthesis of nuclear DNA exhibited a wave-shaped dynamics. The intervals between the maximal values of the DNA synthesis constituted 3 days. Within the early steps of wound healing the intensive incorporation of 3H-thymidine into mitochondrial DNA was found, which appears to occur due to active mitochondriogenesis. In dynamics of total and nuclear RNA contents two peaks were observed, which did not coincide in time, thus suggesting the wave-shaped increase in biosynthetic processes in cells.

Animals↗