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Biomedical subjects

G P Maxwell

Publications and source records attributed to G P Maxwell.

At least 19 recordsLinked to original sources

The polyurethane-covered mammary prosthesis: facts and fiction (II): a look back and a "peek" ahead.

The senior author believes that there is a niche for polyurethane-covered devices in the new millennium if they in fact become available. During the span of this author's practice, he has never been able to match the number and quality of superior results exemplified by these patients when using other devices. Women seeking reconstruction after mastectomy or aesthetic improvement will be well served if the polyurethane-covered device once again becomes one of the choices of mammary prostheses available to them, in this author's opinion.

Breast Implants↗

Ipsilateral pedicled TRAM flaps: the safer alternative?

Transverse rectus abdominis myocutaneous (TRAM) flap breast reconstruction has become a commonly performed procedure in the 1990s. The original description of the procedure was that of an ipsilaterally based pedicle procedure. Concerns about potential folding of the pedicle with possible compromise of the vascular supply led many surgeons to prefer the contralateral pedicle. Subsequently, there have been several large clinical series of pedicled TRAM flaps showing a relatively high complication rate related to flap vascularity problems. Partial flap necrosis rates in pedicled TRAM series range from 5 to 44 percent. These findings resulted in many centers favoring free TRAM flap breast reconstruction, despite an increase in resource use and negligible differences in complication rates. Ipsilateral pedicle TRAM flap breast reconstruction is not a commonly reported procedure and is reserved for cases for which scars preclude use of the contralateral pedicle. Simplicity and versatility of flap shaping, improved maintenance of the inframammary fold, and lack of disruption of the natural xiphoid hollow give ipsilateral TRAM flaps further advantages. This study reports on a series of 252 consecutive ipsilateral TRAM flap reconstructions in 190 patients. The majority of patients underwent muscle-sparing procedures with preservation of a medial and a lateral strip of rectus muscle. Immediate reconstruction was done in 104 of the 190 patients. Skin-sparing (69 patients) or skin-reduction procedures (21 patients) were used in 90 of the 104 patients (87 percent) undergoing immediate reconstruction. Complication rates were comparable to those of series reported for contralateral TRAM flaps, except that partial flap necrosis (2.0 percent) was less in this series. Risk factors were analyzed with regard to the most common complications seen in this study. Ipsilateral TRAM flap breast reconstruction is our preferred method, if available, because we believe that it has several advantages over the contralateral pedicled TRAM and this report suggests a lower partial flap necrosis rate than previously reported.

Adult↗

Use of hollow cannula technology in ultrasound-assisted lipoplasty.

In this article, the author discusses the current technology behind ultrasound-assisted lipoplasty. He reviews the generator, interconnecting cable and handpiece, titanium probes or cannula, introducer sleeve, infusion pump, and evacuation cannulas. Clinical technique, including patient selection and indications, site preparation, hollow-cannula emulsification, evacuation, dressing, and postoperative care is discussed.

Catheterization↗

Tissue temperatures during ultrasound-assisted lipoplasty.

Removing excess subcutaneous fat with the assistance of ultrasonic energy has recently become a technique of interest in the United States after nearly a decade of use in Europe. There are a number of reported advantages of ultrasound-assisted lipoplasty over traditional liposuction, and there are also some theoretical concerns. Ultrasound-assisted lipoplasty involves the conversion of electrical energy to mechanical energy and transfer to the tissues through acoustic pressure waves, with the formation of heat as a by-product. Heat generated in this process dissipates through the body's own cooling mechanisms and conduction to the surrounding tissues, and it does not contribute to the clinical treatment of the adipose tissue. Reports of "burns" and ischemic skin injuries in the literature, and concerns for potential heat-related problems, prompted us to investigate whether significant temperature elevations occur in the clinical setting. Subcutaneous tissue temperature determinations during ultrasound-assisted lipoplasty were begun in February of 1996, and data were collected from 55 patients who had the procedure performed during a 6-month period. Intraoperatively, temperature measurements were made with a data-logging instrument and a needle microprobe inserted into the subcutaneous tissues. Temperatures were taken in the area of liposuction before the infusion of tumescent fluid, after tumescent fluid infusion, and at 5-minute intervals until the end of the procedure. The patient's core body temperature remained stable during the procedure within a narrow range (35.7 degrees C to 36.3 degrees C). There was a gradual increase in the temperature of the subcutaneous tissues over time during the application of ultrasonic energy; however, average subcutaneous temperatures remained below the core temperature (p < 0.05) at all time intervals. Room-temperature tumescent fluid further enhanced the thermal safety zone without lowering core body temperature. There were no temperature related complications in our study population and no untoward effects of performing temperature measurements. We conclude that there is no clinically significant elevation of subcutaneous temperatures during ultrasound-assisted lipoplasty. Reported ischemic skin complications are more likely the result of injury to the subdermal plexus rather than a temperature-induced thermal injury. Although heat is a natural by-product of the energy transfer involved in ultrasound-assisted lipoplasty, the risk of thermal injury is negligible when the procedure is performed by experienced operators. Complete understanding of the technique along with strict adherence to basic principles of flap vascularity will ensure safe and effective performance of ultrasound-assisted lipoplasty.

Adult↗

Ultrasound assisted lipoplasty--Part 1: An overview for nurses.

The use of ultrasound assisted lipoplasty (UAL) to assist in the removal of subcutaneous fat has been practiced in Europe for nearly a decade but has only recently been practiced in the United States. This article will discuss the UAL procedure, its history, regulatory issues, instrumentation and equipment needed, clinical protocol, case reports, complications, and future considerations.

Education, Nursing, Continuing↗

Evaluation of silicone-gel sheeting on early wound healing of linear incisions.

Topical silicone-gel sheeting has been shown to be beneficial in the treatment of established hypertrophic and keloid scars. Certain individuals and incisions in specific body sites appear to be at increased risk for the development of such scars. A simple, inexpensive, and preventive treatment in these individuals at increased risk could potentially minimize the extended period of pressure therapy and repeated steroid injections that are often required to optimize outcome. However, the effects of applying silicone-gel sheeting in the immediate postoperative period as a preventive measure have not been investigated to date. Because silicone-gel sheeting influences the remodeling and maturation phase of collagen formation, we believed it prudent to determine whether silicone-gel sheeting had any deleterious effect on early wound healing, as demonstrated by in vivo biomechanical testing of wound strength and histological assessment. To investigate the potential effects of silicone-gel sheeting on acute wound healing and its possible application for prevention of hypertrophic scars, a study was designed in the hairless guinea pig. In phase 1 of the study, bilateral dorsolateral incisions were made, allowing each guinea pig to serve as its own control. One wound was dressed with silicone-gel sheeting, and the control site was dressed with Nu-gauze dressing. Wounds were then assessed visually and with in vivo biomechanical analysis of wound strength at days 3, 5, and 7 postoperatively (n = 7 per group). Phase 2 of the study compared identical dressings in a similar animal model using a single dorsal midline incision, in which alternate halves of each wound served as the control.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

A rat transverse rectus abdominis musculocutaneous flap model: effects of pharmacological manipulation.

A study was designed to attempt to develop an experimental animal model for the transverse rectus abdominis musculocutaneous (TRAM) flap. The rat has a well-formed superior epigastric artery with musculocutaneous perforators that have been shown to support a musculocutaneous flap on a single superior pedicle. Despite the anatomical differences between the dominance of the axial longitudinal cutaneous circulation in loose-skinned animals compared with humans, as well as a dominant superior intramuscular pedicle, the rat TRAM model appears to be reproducible and has predictable zones of viability as well as areas that typically do not survive when based on a single superior pedicle. These areas of nonviability correspond to those zones at high risk of nonviability in the human clinical situation: zone 3 and 4 on the contralateral side and zone 3 on the ipsilateral side (tissue lateral to the superficial inferior epigastric supply). Once the reliability and reproducibility of this model was demonstrated (coefficient of variation 18.9%), a study was undertaken to determine whether pharmacological manipulation of this flap altered survival in those areas that are inadequately perfused. The two agents tested were allopurinol (xanthine oxidase inhibitor, antioxidant) and pentoxifylline (microcirculatory rheological agents that is a xanthine analogue and is also believed to have antioxidant potential). The study involved creating right unipedicled TRAM flaps in 30 male specific pathogen-free Sprague-Dawley rats weighing 375 to 450 gm. The transverse skin paddle was centered over the umbilical dimple and measured 5.5 x 2 cm.(ABSTRACT TRUNCATED AT 250 WORDS)

Allopurinol↗

A rat model for capsular contracture: the effects of surface texturing.

There has been ongoing clinical and laboratory research to determine the role of surface morphology on capsular contracture. The purpose of this study was to develop a rat model in which capsular contracture occurred frequently and to determine whether surface texturing had any effect on the incidence or degree of capsular contracture as determined by in vivo biomechanical analysis of tissue modulus and histological examination of the tissue at the capsule-implant interface. A new sublatissimus implantation site in the rat was developed in an attempt to avoid subpannicular placement, which has been associated with inconsistent results because of contracture despite texturing, and a high rate of implant exposure secondary to trauma. Each rat (N = 43) was implanted with two devices--one smooth-surface 6-ml implant and one textured Biocell 6-ml implant--both with remote ports to allow for biomechanical analysis. Evaluation was carried out at 1, 2, and 3 months (n = 10) and 6 months (n = 5). Biomechanical evaluation of the implants was carried out in vivo and anonymously. The animals were then killed, and sectioning of the overlying capsule-implant interface from the dome of the implant was performed. Histological evaluation was carried out anonymously with regards to the implant type. Capsular contracture developed in smooth-surface devices in 95% of sites; this became evident on biomechanical analysis at 2 months and progressed to 3 months, after which it remained relatively stable.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

Secondary shaping of the TRAM flap.

Excellent results from TRAM flap reconstruction depend on proper patient selection and proper surgical planning and execution. It is difficult to achieve perfection and completion of the reconstruction in a single operative procedure. The second stage gives the surgeon an excellent opportunity to not only perform the nipple-areola reconstruction but also to enhance the quality of the initial procedure and give the patient the best possible result as well.

Female↗

An intraoperative patient stabilization device.

An intraoperative patient stabilization device is described for use in aesthetic breast surgery. This simple device maintains the patient in the vertical position throughout the many positional changes during aesthetic breast surgery.

Female↗

A method for detection of a punctured saline tissue expander.

Inadvertent puncture of a tissue expander from a needle can occur both intraoperatively and postoperatively. With a small puncture hole and a partially filled expander, detection of the hole can be very difficult, especially in the postoperative period when removal of the entire device may become necessary for adequate examination. A simple method is described to detect the presence of such a leak with the use of fluorescein dye.

Adult↗

Morphologic analysis of tissue-expander shape using a biomechanical model.

Using a biomechanical model designed to reproduce the forces exerted by the soft tissues of the chest wall, the contours created by several currently available round as well as anatomically shaped tissue expanders were evaluated. Parameters that describe expander shape were defined, the most useful of which proved to be the point of maximal projection and the percentage of upper pole deformity. Direct comparison of seven different expanders with respect to these variables revealed the anatomically shaped expanders to offer improved contours over traditional round designs. Continuing modifications in expander design should focus on lowering the point of maximal projection and minimizing the upper pole deformity.

Biomechanical Phenomena↗

The biomechanical and histopathologic effects of surface texturing with silicone and polyurethane in tissue implantation and expansion.

There has been considerable interest in determining the effect of morphologic alterations of prosthetic surfaces on capsule response in breast surgery. The purpose of this study was to provide a precise, three-dimensional evaluation of soft-tissue response to surface modifications in both implantation and expansion. Expandable 100-cc prostheses were designed with one of three surfaces: textured silicone (Biocell), standard smooth silicone, or polyurethane (Natural-Y, Meme). A new submuscular implantation site in the rabbit was developed. Each animal randomly received a smooth-surface device on one side and either a textured silicone or polyurethane device on the other. In one group of animals, the prostheses were expanded monthly. Capsular response was evaluated monthly in vivo using standardized techniques as well as biomechanical methods for up to 6 months in the expander group (n = 7 to 16) and 8 months in the implant group (n = 7 to 15). Analysis of biomechanical and histologic data revealed that prosthetic surface morphology can specifically alter capsular response. Polyurethane was the only effective surface in preventing capsular contracture in implantation. In expansion, both textured silicone and polyurethane surfaces resulted in significantly less capsular contracture and less resistance to expansion than comparable smooth-surfaced controls. Statistical comparisons reveal that the biomechanical methods utilized in this study provide the most precise and objective method of defining overall soft-tissue contracture around implanted biomaterials.

Animals↗

Eighty-four consecutive breast reconstructions using a textured silicone tissue expander.

Breast reconstruction utilizing smooth-surface silicone tissue expanders is associated with certain problems. Significant capsular contracture may develop around the expander with subsequent expander displacement necessitating repositioning or capsulectomy at the time of expander removal. Infection, pain on expansion, chest-wall compression, and complications related to the remote fill valve also have been reported. A textured-surface silicone expander with an integrated fill valve was developed to address these issues. Eighty-four consecutive breast reconstructions were performed by a single surgeon using textured expanders in 55 patients. Intraexpander pressures were measured during expansion for a group of these patients, and both initial and postinflation pressure readings were quite low (average initial pressure 2.88 mmHg; average postinflation pressure 12.87 mmHg). Eighty-one of the reconstructions have been completed without any expander losses and with minimal complications. Tissue expander volume averaged 580 cc, and the expansion duration averaged 5.6 months. Various types and configurations of permanent implants were used to complete the reconstructions. Eighty-four percent of our patients' completed reconstructions (including nippleareola reconstruction and opposite breast alteration, when necessary) were accomplished with just two procedures. Seventeen long-term adjustable textured-surface expander/implants with anatomic breast shape are still in place, all after only one operation. The inframmary fold has generally been established passively by the expansion process alone. Textured-surface silicone expanders have stayed where positioned, have expanded easily with minimal patient pain, and have created a noncontractile soft-tissue cover for the final implant. The textured expander with an integrated fill valve has simplified breast reconstruction by helping to limit the problems encountered with smooth silicone expanders. The resulting reconstructions have remained soft with a very acceptable aesthetic appearance. The patient office and hospital charts and photographs of this consecutive series were notarized and submitted to the Editor of this Journal, whose biostatistician randomly selected the cases illustrated.

Equipment Design↗