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Biomedical subjects

G Pagani

Publications and source records attributed to G Pagani.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Selective phytotoxic activity of N,N-di,sec.butylamides of aminobenzoic acids mono-, di- and tri-substituted on the nucleus].

N,N-di,sec.butylaminobenzamides, mono-, di- or trisubstituted on the nucleus with methyl and/or halogen groups were prepared and tested for phytotoxicity. The corresponding benzoic acids and series of N-alkyl- and N,N-dialkylamides of 2-amino-3-bromo-5-methyl-, 2-amino-3,5-dibromo, 2-amino-3,5-dichloro- and 3-amino-2,5-dichlorobenzoic acids were studied in parallel. Both pre- and post-emergence phytotoxicity tests were carried out with doses of 6 kg/ha or less on seven representative weeds and some plants of agricultural interest. The series of N,N-di,sec.butylamides studied proved to be effectively phytotoxic on absorption through either the roots or the foliage. As regards the effect of substitution in the nucleus on the phytotoxicity of these amides, 3,5-dihalogenation proved important. The results also showed: 1) the importance of two sec.butyl groups on the amide nitrogen for the appearance of selective phytotoxicity against two grass weeds; 2) the different behaviour of the two acids (XXIa) and (XXIIa) in comparison with the corresponding di,sec.butylamides (XXI) and (XXII); 3) the importance of derivative (IL) which was highly active against graminaceous weeds but showed low phytotoxicity against crop plants, graminaceous ones included.

Aminobenzoates↗
PubMed1978

[Phytotoxic activity of asymmetric 3,4-dichlorobenzoic acid dialkylamides].

The phytotoxicity of asymmetric N,N-dialkyl-3,4-dichlorobenzamides was studied in pre- and post-emergence tests against some weed species. The amide groups were characterized by the presence of a sec.butyl or 1-methylbutyl group and a variable second alkyl group either linear, branched, saturated or unsaturated. Isomers of the above compounds were also prepared and tested as useful comparison materials; these isomers have n.butyl or ter.butyl in place of sec.butyl or a 1-ethylpropyl in place of 1-methylbutyl or other branched alkyl groups with 5 or 6 carbon atoms, always having a methyl group in the alpha position, in place of the 1-methylbutyl and a second substituent in C2 leads to C4. The results show that compounds with phytotoxicity and selective action as regards Echinochloa and Setaria are obtained if a sec.butyl group, a 1-methylbutyl or a 1-ethylpropyl group is retained and the second substituent on the N-amide is varied appropriately. The compounds with greater phytotoxicity towards the weeds were further tested against some species of agricultural interest.

Benzamides↗
PubMed1978

[Asymmetric N,N-dialkyl-3,5-dichlorobenzamides having phytotoxic activity].

Asymmetric N,N-dialkyl-3,5-dichlorobenzamides bearing on the amide N a sec.butyl group or a 1-methylbutyl or 1-ethylpropyl and a second C3 or C4 alkyl group which may be branched or linear, saturated or unsaturated, were prepared and tested for phytotoxicity in pre- and post-emergence experiments. As reference compounds were prepared and tested 3,5-dichlorobenzamides, isomers of the first series, characterized by the presence on the amide N of a n.butyl or ter.butyl in place of the sec.butyl, of a 1-ethylpropyl or other branched alkyl in place of the 1-methylbutyl and a second alkyl group (C2 leads to C4) of varying weight and nature. The results show that all the 3,5-dichlorobenzamides studied have high phytotoxic activity and good selectivity in respect of the two graminaceous weeds tested. The amides proving most active against the weeds were tested against some species of agricultural interest. The substances proving active against the weeds and atoxic for the agrarian species were characterized by the presence on the amide N of a branched C4 or C5 group and a second C3 or C4 group.

Benzamides↗
PubMed1978

[Phytotoxic activity of asymmetric N,N-dialkylnaphthamides].

Asymmetric N,N-dialkylnaphthamides, prepared and tested in pre- and post-emergence tests against some representative weeds, showed good or excellent phytotoxicity often with selectivity of action against Echinochloa and Setaria. These amides are characterized by the presence on the amide nitrogen of a sec.butyl or a 1-methylbutyl or a 1-ethylpropyl group together with another alkyl substituent of varying weight and nature. As reference compounds we prepared and tested N,N-dialkyl-alpha-naphthamides, isomers of the compounds under test, bearing on the N atom an alkyl group of avrying composition and a ter.butyl in place of sec. butil or a 1-ethylprophyl or other alpha-branched alkyl in place of the 1-methylbutyl. The results show the importance of alpha-substitution on at least one of the alkyl groups on the amide N as regards the degree of phytotoxicity. Some of the alpha-naphthamides giving interesting results with the weed species tested were further studied using plants of agricultural interest.

Amides↗
PubMed1978

[N,N-Di-(1-ethylpropyl)amides of benzoic and naphthoic acids having phytotoxic activity].

N,N-di-(1-ethylpropyl)amides of benzoic and naphthoic acids suitable substituted in the nucleus were prepared and tested for selective phytotoxic activity in both pre- and post-emergence tests against some weed species. All the amides tested showed good generic phytotoxicity, often with good selectivity, on absorbance through the roots of graminaceous weeds. The nature and degree of phytotoxic activity was influenced by the nature, position and number of substituents on the aromatic nucleus. Confirmation was again obtained of the importance of alpha-substitution in the two alkyl substituents on the amide nitrogen in producing selective phytotoxic activity.

Amides↗
PubMed1976

[Synthetic PH-RH as a pituitary function test in anorexia nervosa].

The hypophyseal gonadotrophin LH reserve was studied in 9 adult women, 5 of whom were suffering from nervous anorexia (N.A.) and 4 normal, by means of subcutaneous injection of 50 mcg of synthetic GN-RH. Basal values of plasmatic LH proved to be significantly lower in N.A. than in the controls where the response to GN-RH was prompt. In patients with N.A., on the other hand, response was practically absent and differences were significant at all stages of the test. The parallel study of basal steroiduria and following methopirone confirmed the torpid hypophyseal response in N.A. These findings confirm previous personal reports and indicate that the GN-RH test is a useful technique for diagnostic and prognostic definition of N.A.

Adult↗
PubMed1976

[The vanishing testis syndrome. Considerations on a case].

The aetiopathogenesis and clinical and diagnostic features of bilateral absence of the testicles in 46XY subjects are briefly reviewed. A eunuchoid 25-yr-old patient with male sex chromatin, 46 XY genotype, plasma testosterone slightly below normal, normal urinary 17-KS unaltered by gonadotropin stimulation, and bilateral absence of the testicles is presented. Examination of the inguinal canal showed a funiculus and ductus deferens residue terminating in an adipose mass. Section of the fibrous duct showed that this mass was full of capillaries and venules. Lesion between the 14th and 16th week of pregnancy is postulated.

Adult↗
PubMed1976

[Primary pericardial mesothelioma: report of a case (author's transl)].

A case of primary pericardial mesothelioma in a 36-year-old man is reported. The disease, with an atypical clinical onset and rapidly fatal course, was diagnosed before death, by means of clinical examination, chest X-rays, cineangiography and microscope examination of pericardial and pleural exudate, revealing the presence of malignant mesothelial cells. Postmortem examination confirmed the diagnosis and revealed thoracic and extrathoracic metastasis. The clinical, anatomic, pathologic aspects, as well as treatment of primary pericardial mesothelioma are discussed.

Adult↗
PubMed1976

[Negative geotropic effect and phytotoxicity of N-quinolinphthalamic acids and allied substances].

N-Quinolinphthalamic acids and allied substances have been prepared and studied for negative geotropic effect and phytotoxic activity. The substances (Tables I leads to III) prepared by fusion of the required anhydride and amine were tested to evaluate the negative geotropic effect on germinating roots of Lens esculenta Moench s.1. and phytotoxicity in both pre- and post-emergence tests against five representative weed species at a dose of 6 kg/ha. It was found that substances (I), (VII), (VIII) and (IX) showed negative geotropic effect of the same order of magnitude as that of the reference substance (alpha-naphthylphthalamic acid). Substances (VII), (VIII) and (IX) proved highly active in the phytotoxicity tests. The simultaneous appearance of geotropic and pre-emergence phytotoxic activity seems to be connected with the presence of an 8-quinoline residue on the amide nitrogen.

Herbicides↗
PubMed1975

[Controlled application of cynarin in the treatment of hyperlipemic syndrome. Observations in 60 cases].

In a controlled trial 2 groups of 30 patients presenting various dislipidemic pictures were treated for 50 days with either 3,5-dihydroxy-1,4-bis-(3,4-dihydroxy-cinnamoyloxy)-cyclohexan-carbonic acid-(1) (cynarin, Listrocol) or placebo. Cynarin provied to be able to induce a significant reduction of the hypercholesteremia, the level of pre-beta-lipoproteins, the beta/alpha-lipoprotein ratio and patients' body weight. The administration of cynaria is, therefore, deemed useful in the prophylaxis and therapy of dislipidemic pictures of the arteriosclerotic disease.

Administration, Oral↗