Biomedical subjects
G Perrin
Publications and source records attributed to G Perrin.
The TSH secretion in the human pituitary adenomas.
TSH secretion by a pituitary tumor is very rare (2%) and it is often associated with another hormone: GH or PRL essentially. We present here nine tumors in which the TSH secretion was proved by immunocytochemistry (ICC) and by RIA in the tumor extracts, in the serum and in the culture medium. Four tumors secreted TSH only. Five tumors secreted TSH and GH predominantly. In 3 of them traces of other hormones (PRL and FSH) were also detected. The "pure" TSH adenomas were monomorphous with typical ultrastructural and immunocytochemical features. Plurihormonal TSH adenomas were bimorphous with different cells secreting GH and TSH or monomorphous with one type of cell which secreted TSH or GH or both TSH and GH. In a majority of the cases, the tumoral TSH secretion induced hyperthyroidism but in 2 patients with TSH adenoma there was euthyroidism and in another with TSH-GH adenoma there was no sign of acromegaly and GH serum levels were normal.
Highest spin n-p states in heavy nuclei via the ( alpha,d) reaction at 218 MeV.
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Inelastic alpha scattering to the giant quadrupole and monopole resonances of 58Ni, 92Mo, and 120Sn at 152 MeV.
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Quadrupole transitions at very small momentum transfer in nuclei.
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[Extra-intracranial shunts by venous grafts interposed on the carotid system].
Patients with occlusive arterial diseases, tumors invading the vascular structures of the skull base or giant aneurysms may benefit from an EICB. Most of the time this can be achieved using a scalp artery. But in cases of a thrombotic ECA, excessively short or thin scalp branches or destruction of those by prior cranial surgery, an interposed venous graft is needed. In the author's series, which consists of 16 patients, the bypass was performed for ICA occlusive diseases in 5, before complete removal of cavernous sinus tumours in 4 and prior to cervical internal carotid ligation for giant aneurysms in 7. The grafts were always harvested from the internal saphenous vein. The proximal site of implantation was CCA (2 cases), ECA (6 cases), ICA (1 case), superior thyroid A (2 cases)--i.e. 11 long grafts--and the trunk of the occipital A--i.e. short grafts in 5 cases. In this series, there was no mortality and no morbidity related to revascularization. The early patency rate, checked with arteriography, was 62.5% (10 cases) and the late one 56.2% (9 cases). Causes of failure, partially related to technical difficulties in 2 cases, were almost always due to an insufficient extra-intracranial pressure gradient (4 cases). Excepted in one case, there was no correlation between patency and the use or not of anti-aggregant and/or heparin. Literature data are summarized and discussed. They all confirm the importance--besides the absence of technical errors--of a sufficient extra-intracranial gradient for obtaining a good patency rate.
["De novo" aneurysms. Apropos of a surgically treated case].
The authors report the case of a 26 years old woman who developed four "new" T aneurysms, ten years after the successful clipping of a vertebro-basilar system aneurysm. This observation is discussed in relation to the literature; current views supporting that aneurysms may result from a combination of inherent and acquired tissue weakness associated with hemodynamic effects are cited. Another twelve cases of "de novo" aneurysms developed in patients without previously carotid ligation and reported in the literature are reviewed. Their characteristics in relation to their localisation and their interval time discovery are discussed. The advisibility of repeated angiograms in some patients with aneurysm is discussed as these patients are at an increased risk of hemorrhage from another "new" aneurysm.
[Education of patients treated with anticoagulants. Evaluation of the quality of care].
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[Use of Cotrel-Dubousset material in C1 C2 instabilities].
The authors report their experience with the C.D. material for the atlantoaxial displacement. Four cases are presented. The characteristics and advantages of this material are discussed, and compared with the other methods of fixation specially the Knodt-Chirossel.
Elastic and inelastic 16O+12C scattering at 38 MeV/nucleon.
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[Cerebral elastance test and evaluation of cerebral autoregulation capacity in the assessment of the ischemic risk].
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[Meningitis from Lyme disease, diagnosed in Marseilles].
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[Variations of intracranial pressure in the surgery of the internal carotid artery in the neck: evaluation of the risk of cerebral lesions].
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A human beta-endorphin pituitary adenoma.
A beta-endorphin (beta END)-containing pituitary adenoma was demonstrated by immunocytochemical, biochemical, and ultrastructural methods in a 43-yr-old man who had impotence, slight testicular atrophy, and an enlarged sella turcica (grade II0), but no manifestations of Cushing's disease. Preoperative hormone data revealed hyperprolactinemia (97 ng/ml), low plasma cortisol levels without circadian rhythm, undetectable plasma ACTH, and normal plasma FSH and LH levels, with an impaired response to LRH. After hypophysectomy, these hormone levels normalized and responded normally to dynamic tests. Immunocytochemically, 30% of the tumor cells reacted only with beta END antiserum. beta END immunoreactivity was the only component revealed by RIA and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A characteristic ultrastructural aspect is also described. These findings demonstrate dissociation in the secretion of the proopiomelanocortin-derived peptides and suggest a relationship between hyperprolactinemia and tumor secretion of beta END.
[Lumbosciatica caused by spondylolisthesis. Results of the surgical treatment by facetolaminectomy and interbody arthrodesis by the posterior approach in a series of 66 cases].
66 patients with spondylolisthesis were reviewed after surgical procedure with a follow-up period of more than a year postoperatively. The indication for the operation was disabling sciatica in all patients. 4 patients had undergone prior excision of the herniated disc. All the patients underwent a removal of the loose posterior element as suggested by the Gill procedure and intervertebral body fusion using a posterior surgical approach. The surgical procedures with only one regressive neurological complication are described. The results are considered from a clinical and anatomo-radiological point of view. In this series 86.5 percent of 66 patients became sciatica-free. 62 percent of the total series rated the end result as excellent or good. 92.4 percent of the patients demonstrated bony fusion between the two grafted vertebrae. The benefits of posterior laminectomy with interbody fusion are also attractive for spondylolisthesis with sciatica.
[Relation between intracranial pressure and residual carotid artery pressure during carotid clamping].
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[Enzootic bovine leukosis application of E.L.I.S.A. technique for the detection of antibodies].
A simple microplate method of enzyme-linked immunosorbent assay (E.L.I.S.A.) for detecting antibodies to bovine leukosis virus (B.L.V.) is described. The antigen consisted of a solution containing the two major antigens of the B.L.V. (gp 51 and p 24) obtained by a technique of purification using CN-Br activated Sepharose 4B. This E.L.I.S.A. was compared with the agar gel immunodiffusion test (A.G.I.D.T.) in a study of 545 bovine sera. The total discrepancy rate between the two tests was 11% with a better sensitivity for E.L.I.S.A.
[Endoscopic aspect of a lymphangioma of the duodenum ].
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