Hemodynamic findings following replacement of the mitral valve with the Beall valve prosthesis.
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Biomedical subjects
Publications and source records attributed to G R Daicoff.
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Arterial pressure, systemic vascular resistance, and viscosity measurements were made on 20 patients, during cardiopulmonary bypass with hemodilution to an average hematocrit reduction of 48 plus or minus 12 percent. The arterial pressure and blood viscosity decreased an average of 56 plus or minus 16 percent and 40 plus or minus 12 percent, respectively. The total peripheral resistance following the start of bypass was significantly below normal (p smaller than 0.005), but not when corrected for the change in viscosity. There was a strong correlation between the extent of pressure reduction and the viscosity decrease with hemodilution (p smaller than 0.01), although not all the changes in pressure could be accounted for in terms of viscosity. There was no apparent correlation between the extent of hypotension as measured by the area of the pressure-time curve below 50 mm. Hg and the presence or absence of postoperative cerebral or cardiac complications, in contrast to other recent reports.
A digital signal processing system for time series analysis with two modes of usage--the first a rapid, hands-on exploratory method, and the second an automatic, printed, labeled graphic output method--is described. The system utilizes a Time Data 1923C system with integral PDP-11 minicomputer, and a console. Major error problems have been contained and a large-volume graphic analysis capability has been developed. Applications include (a) transpulmonary pressure-pulse relationships, (b) elucidation of the multiphasic nature of pulmonary-vein/left-atrial-pressure pulse phenomena, (c) suggestive value of transfer function phenomena as a tool to demonstrate the effect of various loading and ischemic phenomena on the left ventricle, and (d) teaching-demonstration of the techniques of digital signal processing.