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G Ralleigh

Publications and source records attributed to G Ralleigh.

5 recordsLinked to original sources
PubMed2006

The impact of image guided needle biopsy on the outcome of mammographically detected indeterminate microcalcification.

A study was carried out to examine the impact of development in image guided needle biopsy on the outcome of mammographically detected indeterminate microcalcification. Between 01.04.1991 and 31.03.2001, the South East London Breast Screening Programme detected 392 cases of indeterminate microcalcificaton. Histological diagnosis was obtained using open biopsy, fine needle aspiration cytology (FNAC), 18/14 G wide bore needle core biopsy (WBNCB) and 11 G vacuum assisted core biopsy (VACB). The study period group was divided into two. Group A (between 01.04.1991 and 31.03.1996) and group B (between 01.04.1996 and 31.03.2001). There was a significant reduction in the benign open biopsy rate in group B compared to group A (25% vs. 51%) (P=0.0001). Of the malignant cases, there is a higher percentage of ductal carcinoma in situ (DCIS) in group B compared to group A (77% vs. 62%). In conclusion, the implementation of more effective methods of image guided biopsy has led to a 50% reduction in benign open biopsies for indeterminate microcalcification and to an increase in the detection of DCIS.

Biopsy, Needle↗
PubMed2002

15. Image-guided breast biopsy.

The introduction of mammographic screening has led to an increased number of impalpable in situ and invasive breast cancers. Image-guided percutaneous biopsy in these patients has advantages over surgical biopsy, primarily cost savings and reducing the number of operations required for definitive treatment. Image-guided breast biopsy is also useful in palpable lesions. Image-guided biopsy should be used in conjunction with full clinical and imaging work-up as part of the triple assessment protocol. Techniques available include fine needle aspiration, automated needle-gun core and vacuum assisted large core biopsy. Lesions visible on ultrasound are preferentially biopsied using ultrasound guidance, while those seen only mammographically are biopsied using stereotactic guidance. Major complications are rare following image-guided biopsy. In most cases further management can be decided based on the biopsy result. If there is discordance between clinical and imaging features and the biopsy result, image-guided percutaneous biopsy should be repeated or surgical biopsy may be required.

Biopsy, Needle↗
PubMed2001

MR imaging of the skin and nipple of the breast: differentiation between tumour recurrence and post-treatment change.

Contrast-enhanced MR imaging of the breast has been found to be valuable in the assessment of local recurrence of previously treated breast cancer. We looked specifically at the appearances of the skin and nipple of the treated breast in order to describe the appearances of post-treatment change and recurrence in this region. Thirty-nine women treated for breast cancer had MR imaging of one or both breasts reviewed retrospectively with particular attention to the nipple and skin. The skin and chest wall were assessed for patients with mastectomies. All available histology of the skin and/or nipple, obtained following MR imaging, was reviewed. In patients who did not undergo surgery following MR imaging, clinical follow-up was obtained. Six of 39 cases had nodular enhancing areas seen on MR imaging, which correlated with histology demonstrating tumour recurrence within the skin and/or nipple. Of the remaining 33 patients, changes of linear or diffuse enhancement were seen in the skin and/or nipple of 15 patients. These changes were shown to be benign post-treatment changes at surgery/biopsy in 4 cases or by clinical follow-up in the remainder. In this article we demonstrate differing patterns of contrast enhancement within the skin and nipple in recurrent breast carcinoma vs. post-treatment changes. This suggests that contrast-enhanced MR imaging of the breast may be a useful tool in differentiating tumour recurrence from post-treatment changes within the skin and nipple.

Adenocarcinoma, Mucinous↗
PubMed1999

An unusual case of intrapulmonary granulocytic sarcoma presenting as interstitial pneumonitis following allogeneic bone marrow transplantation for acute myeloid leukaemia and responding to donor lymphocyte infusion.

We report a 45-year-old female with AML who underwent a T cell-depleted sibling allograft and relapsed a year later with extramedullary disease involving the lung parenchyma and presenting with the clinical and radiological features of interstitial pneumonitis. The patient was treated with donor lymphocyte infusion (DLI) resulting in complete resolution of the radiological signs. The unusual presentation and the management options are discussed.

Bone Marrow Transplantation↗