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Biomedical subjects

G S Strelin

Publications and source records attributed to G S Strelin.

At least 19 recordsLinked to original sources
PubMed1983

[Morphological changes after large-field irradiation of dogs and autologous bone marrow transplantation].

The effect of an automyelotransplant taken from a nonirradiated area of bone marrow has been studied after large fields irradiation in dogs. Certain changes occurring in the hemopoietic organs and in some other vitally important organs have been revealed. The automyelotransplantation contributes to a quicker repopulation of the bone marrow and stimulates lymphoid hemopoiesis in the spleen; that plays a positive role in overcoming the bone marrow syndrome at radiation illness. In other organs (gastrointestinal tract, kidneys, lungs, heart) given various doses of irradiation, in the control and test (with automyelotransplantation) groups similar morphological changes have been revealed.

Animals↗
PubMed1981

[Effect of immobilization of mice with different radiosensitivities and shielding of part of the bone marrow on survival and spleen colony formation following irradiation].

Experiments on linear F1 (CBA x C57BL) mice resistant to irradiation and random-bred white mice which are more sensitive to irradiation were made to study the relationship of the survival rate of the animals and spleen colony formation to the magnitude of x-ray doses during immobilization and shielding of the crus--factors which increase the resistance. It was shown that low colony formation typical for linear mice remained at a low level during the resistance-increasing immobilization, while in the course of shielding it increased in accordance with the animals' survival rate. In random-bred mice, the survival rate and colony formation were in good agreement in all the cases. The conclusion is made that colony formation cannot be regarded as an adequate criterion for the survival rate.

Animals↗
PubMed1979

[State of several rat hematopoietic organs following total and subtotal irradiation and after bone marrow autotransplantation].

Hemopoiesis was studied in rats after x-ray irradiation. Lethal doses of 800--820 R were applied totally, with screening the shin and with subsequent autotransplantation of bone marrow taken from noninjured hemopoietic tissue. Survival of the animals and status of hemopoietic organs (quantitative indices of the peripheral blood, bone marrow and the spleen, as well as morphological changes in hemopoietic organs) served as tests. All totally irradiated animals died by the 20th day, the 30th day in the group of screened animals 32% survived, in the group with autotransplantation of bone marrow--62%. According to the indices studied restoration of hemopoiesis proceeded more quickly and completely in the group with autotransplantation of bone marrow and somewhat slower in the group with screening the shin (but without autotransplantation); this was accompanied by repopulation of bone marrow comparing with the totally irradiated animals. Restoration of the hemopoietic organs was followed by a comparatively rapid increase in the number of myeloid cells, while the number of lymphoid cells increased more slowly.

Animals↗
PubMed1979

[Hematopoietic stem cell migration study in dogs].

The migration rate of stem hemopoietic cells (SHC) of the bone marrow was studied by two methods in experiments on 54 dogs. In the first case the dogs were irradiated with an absolute lethal dose (550 R) subtotally, shielding two knee-joints. Seven days after the first irradiation under inactivation of shielded parts with 2000 R dose the survival rate was 12.5% and after 14-day inactivation all the dogs survived. In the second case firstly both knee-joints were irradiated with 2000 R dose. All the animals died following subsequent subtotal irradiation of the areas previously irradiated with 550 R dose if the second irradiation was performed 7 days after the first one. Prolongation of the time intervals between irradiations up to 31 days lead to 20% survival of the animals. It was concluded that SHC migration in dogs is much lower than in mice.

Animals↗
PubMed1976

[Use of autologous bone marrow taken from a shielded area at different times after irradiation].

It was shown that in X-irradiation of rats in the absolute lethal dose (850 R) shielding of the shank saved 32% of the animals from death. Bone marrow autotransplantation from the shielded portion immediately after the irradiation augmented the shielding effect considerably. Such protective action of autotransplantation persists if conducted in the course of the first 5 days after the irradiation, but it decreases later (on the 7th-10th day).

Animals↗