[The use of human fibrin glue in microanastomoses of the femoral artery and vein of the rat].
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Biomedical subjects
Publications and source records attributed to G Sani.
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The Authors have verified the utility of the Laser CO2 instrument for termino-terminal anastomosis of the uterine horns of the rat. In this study Laser tecnique is compared with the same traditional microsurgical operation. No significant difference was seen in the number of pregnancies nor fetuses born. On the contrary, hystological observation has shown lower reactivity in the group treated with Laser technique 10 days. In this group it was also noted that there was less formation of postoperative adhesions, and, during the operation, there was easier dissection of the tissues accompanied by lower blood loss and necrotic debris.
The Authors have studied the lower trombogenicity following interposition of an arterial patch in a venous termino-terminal microanastomosis. The microsurgical operation was performed on the femoral vessels of the rat. A tract, cm 0.8-1 long, of femoral artery was excised and after washing in Emagel solution, was interposed in the femoral vein of the opposite leg. The patency of the femoral vein was verified at the end of the anastomosis. We also studied the histological change of the arterial patch grafted both 10 and 30 days after the operation. A progressive reduction of the reactivity around the nylon sutures and an increasing venous metaplasia was found correlating with time.
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Cardiocirculatory stability and arterial blood oxygenation represent the major problems in chest and lung surgery. The need to cut ventilation off from one of the lungs, or from a segment of a lung, may lead to dangerous haemodynamic and respiratory changes. The use of neuroleptoanalgesia guarantees marked cardiocirculatory stability but problems arise out of the need to administer high percentage nitrogen protoxide with consequent hypoxaemia. The use of Althesin surmounted this inconvenience and made it possible to keep basic haemodynamic parameters (heart stroke volume, peripheral resistances, lung resistances) and respiratory parameters (partial pressure in O2 and CO2 in the arterial and venous blood) stable.
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