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Biomedical subjects

G Sterner

Publications and source records attributed to G Sterner.

At least 91 records · Page 5Linked to original sources
PubMed1977

Chronic active hepatitis in children. A clinical and immunological long-term study.

Six girls and one boy with cronic active hepatitis (CAH) of unknown etiology were between 9 and 15 years at the clinical onset of their illness. After beginning immunosuppressive therapy the course of their disease was followed from one to ten years. All had markedly increased IgG, high titres of smooth muscle antibodies (SMA) and antinuclear antibodies of IgG class in the earliest serum specimens tested. Therapy resulted in an improved sense of well-being and a decrease in SGOT, IgG and titres of SMA. Very high titres of measles antibodies were observed in all cases. In one of the cases CAH manifested itself after measles and in another after rubella infection. The first case in our series of patients died of liver failure after 5 years of illness. The other patients have survived and are able to live a normal life. The possibility of CAH should be considered when children develop symptoms of hepatitis. Longterm immunosuppressive treatment with regular clinical and laboratory evaluation is important. Estimation of titres of SMA is an additional parameter of value in following of the activity of CAH in these young patients.

Adolescent↗
PubMed1977

African trypanosomiasis: a danger for tourists visiting Gambia?

A 30-year-old Swedish woman visiting Gambia in 1975 acquired trypanosomiasis probably of the Gambian type. The first sign of her disease appeared as a trypanosomal chancre on her right thigh, soon followed by lymphadenitis in her right groin. One week later she became febrile and therefore hospitalized after returning to Sweden. The diagnosis was established by demonstrating numerous trypanosomes in a blood smear. 10 pentamidine injections (200 mg once daily intramuscularly cured her disease. The risk of acquiring trypanosomiasis in Gambia seems to be extremely small for tourists, but not quite negligible.

Adult↗
PubMed1977

Studies on the clinical efficacy, serum levels and side effects of clindamycin phosphate administered intravenously.

Clindamycin phosphate was administered intravenously to 41 patients with different types of infections including osteomyelitis, septicaemia and soft tissue infections. All bacterial strains tested showed low MIC values for clindamycin. Maximum serum concentrations after 600 mg intravenously were 6.0--29.0 microgram/ml, after 300 mg intravenously 2.6--26.0 microgram/ml. The therapeutic effect of the drug was considered good in 26 of 31 patients with proven or probable bacterial aetiology. Side effects were noted in 16 of the 41 patients. However, in only 5 of these the treatment had to be terminated, all due to pruritic rashes. In the 7 cases with diarrhoea as side effect, the symptoms were mild and of short duration.

Adult↗
PubMed1976

Effect of Mycoplasma pheumoniae infection on cell-mediated immunity.

The effect of Mycoplasma pneumoniae infection on cell-mediated immunity was examined by two methods: the first method was the tuberculin skin test and the other was the measurement of the in vitro lymphocyte stimulation response to purified protein derivative (PPD) of tuberculin. Twenty-nine patients out of a total of 47 patients with a lower respiratory tract illness caused by M. pneumoniae had a negative tuberculin skin test when first tested. Twenty-three out of 26 patients with a negative tuberculin reaction in the early phase of the illness had a positive skin test when they were retested several weeks or months after the illness. The lymphocyte stimulation response to PPD was examined in 13 patients. In eight of these cases the lymphocyte response to PPD was significantly lower during illness than after recovery. Six control subjects showed no significant difference in their lymphocyte responsiveness to PPD when examined on two different occasions. These studies show that M.pneumoniae infection causes transient depression of cell-mediated immunity.

Humans↗
PubMed1976

Tuberculin anergy in patients with Mycoplasma pneumoniae infection.

Skin testing for delayed hypersensitivity to tuberculin was performed in 36 patients with pneumonia associated with Mycoplasma pneumoniae infection. 22 of these patients had a negative tuberculin reaction when first tested. The tuberculin reaction was negative in 13 out of 16 cases tested during the first 2 weeks after onset of illness, in 6 out of 11 cases tested 15-28 days after onset of illness and in 3 out of 9 cases tested 29-45 days after clinical onset. In 19 patients with a negative tuberculin test in the early phase after onset of illness the test was repeated several weeks or months later. 16 of these cases had a positive tuberculin reaction at the later time period. Two of these cases showed prolonged tuberculin anergy for more than 5 months.

Adolescent↗
PubMed1976

Smooth muscle antibodies in Mycoplasma pneumoniae infection.

Paired sera from forty-five cases of Mycoplasma pneumoniae (MP) infection associated with acute lower respiratory tract illness were examined by immunofluorescence for antibodies to smooth muscle. Twenty-five (56%) of these cases had smooth muscle antibodies (SMA) of IgM class. A significant (greater than or equal to 4-fold) increase in titre of these antibodies was demonstrated in fifteen of thirty-five patients with a significant rise in titre of MP antibodies. SMA of IgG class occurred in eleven of forty-five cases (24%), but a 4-fold rise in antibody titre was found only in two cases. Three of forty-five sera (7%) from healthy donors contained SMA of IgM class and eight sera (18%) SMA of IgG class. MP antigen did not absorb SMA. Liver tests were performed in twenty-nine patients. In eighteen patients SGPT values were moderately or slightly elevated. There was no correlation between the occurrence of increased levels of transaminases and the presence of SMA in serum. In a patient with active chronic hepatitis, who had had a high titre of SMA exclusively of IgG class for 2 years, SMA of IgM class appeared transiently in association with an acute respiratory illness due to MP.

Antibodies↗
PubMed1972

Outbreak of giardiasis: effect of a new antiflagellate drug, tinidazole.

We describe here an intensive outbreak of mostly symptomatic (90%) Giardia lamblia infestation in a Swedish student group visiting the U.S.S.R. A new antiflagellate drug, ethyl (2-(2-methyl-5-nitro-1-imidazolyl)ethyl) sulphone, tinidazole, Pfizer, was given in a dosage of 150 mg twice daily for seven days to 10 healthy volunteers and to 24 students infested with G. lamblia. The drug was found to be effective in curing giardiasis and in eradicating G. lamblia from the intestinal tract. All the students with symptomatic giardia infestation became free from gastrointestinal disturbance, usually soon after treatment was started. None of the 24 students had G. lamblia in their stools after tinidazole treatment was discontinued or at follow-up. No side effects of the drug were seen and all of the subjects tolerated it very well.

Adult↗