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Biomedical subjects

G Tedde

Publications and source records attributed to G Tedde.

At least 19 recordsLinked to original sources
PubMed1993

Lichen planus in children: a case report.

Lichen planus (LP) is rare in children. A review of the literature reveals that it has some peculiarities with respect to sex, localization, clinical aspect, race, and family history. We present an Indian child with the documented peculiarities of infantile LP. A comparison of LP and graft-versus-host disease points to the importance of thymic involution in the pathogenesis of the former, which could explain the rarity of this disorder in infants.

Biopsy↗
PubMed1993

Structural pattern of the mitoses and hollow formations in the human embryo.

Hollow formations in very early stages of the human embryo development have been studied, regarding the behaviour of the mitoses. Semithin sections of the neural tube, of the fissure of the optic cup, and of somites yet furnished with the myocoelic cavity have been observed at the light microscope, after staining with toluidine blue. In all the observed buds a particular and very interesting result has been obtained: all the mitoses are placed in the lining cellular layer looking at the cavity. Dividing cells in the thickness of the wall of the buds are always lacking. In all the cases the dividing cells and the most of the others during the interphase appear to be closely linked to the inner surface of the wall, in the adluminal layer, at level of which cell evaginations form characteristic palings. A hypothesis has been advanced concerning the influence that active substances in the fluid filling the cavities may have in the control of the mitotic processes of the cellular wall.

Embryo, Mammalian↗
PubMed1993

Primary osteoma cutis. Clinical, morphological, and ultrastructural study.

Primary osteoma cutis arises in the deeper dermis for no apparent reason and presents as mature, lamellar, and osteonic bone; secondary cutaneous osteomas are correlated with inflammatory processes, scars, or dysembryoplasia and are always composed of osteoid. Ultrastructural findings of primary cutaneous osteomas have not been reported to date. Light and electron microscopic findings of a case of primary osteoma cutis are described: mineralized areas may be divided into macrocalcification and microcalcification. Macrocalcification consists of lamellar bone. Osteocytes populate the lamellae, whereas collagen fibril distribution is bone-like. Hydroxyapatite deposition presents as globular or needle-like electron-dense material progressively masking the connective tissue matrix. Microcalcifications, which are found in macroscopically normal dermis around the calcified plaque, consist of osteoid tissue inhabited by osteoblast-like cells. Microcalcifications may be interpreted as metastatic calcifications related to the primary osteoma calcified plaque. Primary osteoma cutis may be considered as true bone amartothic formation rather than dermal mineralization.

Adult↗
PubMed1991

Morphological changes in human chorionic villi cultivated in conditioned atmospheres of gases.

With the aim to verify the changes that a reduction of the oxygen rate may elicit in the morphological pattern of the human chorionic villi, a new experimental procedure has been suggested. Chorionic villi from human early placentas were incubated in Dulbecco's modified medium of Eagle in the presence of oxygen, air or CO2 at a gas pressure equal to 0.7 atm. The specimens were fixed, dehydrated and embedded in resin, and semithin sections were obtained. Using an image analyser, the thickness of the trophoblastic layer and the mean radius of the villi were evaluated and the results submitted to a statistical analysis. The results show a decrease in the ratio thickness of the trophoblast/mean radius of the villus, directly proportional to the reduction of the oxygen percentage in the employed gases. The interesting conclusions demonstrate that the changes which affect the chorionic villi occur very early and are easily evaluable with quantitative methods; a clinical interest in the use of the proposed quantitative procedure can be emphasized.

Air↗
PubMed1990

[Proposal for a dynamic study of the temporo-mandibular joint, using a computerized image analyzer].

With the aim to go deep into the knowledge of the morpho-functional anatomical characteristics of the temporo-mandibular joint in humans, a dynamic method of study by means of a computerized analyzer of images is suggested. The acquired advantages are the following: a) the accuracy of evaluation of the chosen morphometric parameters; b) the working speed, from which results: c) the possibility to increase adequately the number of cases and d) the possibility to easily investigate many parameters with a very high accuracy of the quantitative results. Both right and left temporo-mandibular joints of adult individuals aged from 18 to 53 have been studied utilizing lateral tomographies focused at 3.3 mm to the lateral surface of the condylar head. The evaluations were done both in the position of completely closed mouth and in extreme opening. From the barycentre of the condyle several straight lines were drawn according to the figure 2. The length of the segment a-b (distance of profiles of the condyle and mandibular fossa) were evaluated in all the lines counter-clockwise and the results submitted to a statistical analysis. The results furnish very good information on the normal or pathological anatomical characteristics, of the joint.

Adult↗
PubMed1987

Action of anticytoskeletal compounds on in vitro cytopathic effect, phagocytosis, and adhesiveness of Trichomonas vaginalis.

The cytopathic effects of Trichomonas vaginalis treated with inhibitory concentrations of anticytoskeletal compounds (mebendazole, griseofulvin, colchicine, taxol, and cytochalasin B) were studied in mouse CLID fibroblast cultures. The evaluation, at different times, of cell numbers and morphological alterations showed that cytopathic effect was considerably reduced when protozoa were pretreated with mebendazole and griseofulvin, whereas colchicine, taxol, and cytochalasin B had less effect. Furthermore, treatment with mebendazole, griseofulvin, and colchicine decreased adhesiveness of the protozoan, whereas treatment with cytochalasin B and colchicine completely inhibited its phagocytic activity. From these results it may be concluded that alterations induced in the trichomonal cytoskeleton may affect its adhesiveness and its in vitro cytopathic effect, but there is no direct correlation between protozoan phagocytosis and its in vitro pathogenic effect.

Alkaloids↗
PubMed1984

[Development of human fetal skin from the beginning of pregnancy to the 6th month. Light microscopy study].

The human foetal skin has been studied in 15 foetuses from the 8th to the 24th week of pregnancy, to analyse the most significative stages of its evolution. The skin of the ventral and dorsal regions of the hand and fingers has been studied. Just after excision, the hand buds have been fixed with neutral formaline, dehydrated, clarified and embedded in paraffin. The microtomic sections have been stained using different histological techniques. Different characteristics between the skin that will differentiate into thin and thick aspects have been observed already from the earliest stages of evolution. The differences occur especially at the level of the subepithelial mesenchyme, that conditions the development and the evolution of the two kinds of skin.

Cell Differentiation↗
PubMed1984

[Innervation of the human testes studied with electron microscopy].

The testes of 35 men from 2 to 61 years old have been studied by electron microscopy with the aim of stressing the presence and the topographic localization of the efferent nervous fibres. The researches have confirmed that the innervation of the male gonad shows three components: a) vasomotor, b) peritubular, c) interstitial. The results obtained point out the very important role that the vegetative nervous system plays in the regulation of the gonadal functions.

Adolescent↗
PubMed1983

Experimental varicocele in the rat--a new experimental model. I. Effect on testicular structure.

A new experimental model of a varicoele in the rat is proposed. The study has been carried out on the Wistar rat in which the gonadal vein enters into the iliac vein. A varicocoele was induced in different ways: by complete or incomplete ligature of the iliac vein medial to the entry of the gonadal bein (Group I and II); by creating a venous compression by positioning the iliac artery in front of the vein, thus reproducing the so called "nut cracker" phenomenon (Group III); by creation of a small arterio-venous fistula by means of a side-to-side anastomosis between the iliac artery and vein. The results were studied macroscopically and histologically. The damage was most evident in Group III and significant in Group IV, but the absence of damage to the contralateral testis remains unexplained.

Animals↗
PubMed1982

[Morphometric ultrastructure study of the trophoblast during gestation].

The results obtained by studying the normal human placenta with stereological and morphometric methods are reported, particularly the volume fractions of the syncytial nuclei and cytoplasmic organelles, the morphometry of the syncytial nuclei and the thickness of the basement membrane of the trophoblast. All parameters have been followed throughout pregnancy. The possibility of utilization of quantitative methods for the study of placentas in pathological pregnancies has been discussed.

Cell Nucleus↗
PubMed1981

[Steroidogenic activity in the amniotic epithelium].

For evaluation of the steroid-producing structures during pregnancy, the human amnion has been studied from the early stages of pregnancy to the term by means of histo-enzymologic and submicroscopic techniques. The histo-enzymatic tests have shown the presence hydroxysteroid of 3 beta-hydroxysteroid-dehydrogenase in the cells of the amniotic epithelium throughout pregnancy. Also scattered mesenchymal cells of the subepithelial fibroblastic layer showed a positive reaction in their cytoplasm. Using FRIEND and BRASSIL's (1970) technique a steroidogenetic activity has been demonstrated at the level of the amniotic epithelium both in semithin and in ultrathin sections, the latter observed by electron microscopy. The above mentioned results suggest that the amniotic epithelium represents a site of steroidogenesis and conversion of steroids and plays, also under this point of view, an important role in the physiology of pregnancy.

3-Hydroxysteroid Dehydrogenases↗