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Biomedical subjects

G Uza

Publications and source records attributed to G Uza.

At least 19 recordsLinked to original sources
PubMed2000

Magnesium and calcium concentration in the abdominal aorta of patients deceased by ischemic heart disease.

Magnesium (Mg) and calcium (Ca) concentrations were determined in the abdominal aorta of 28 patients who died by acute myocardial infarction (AMI), of 52 by ischemic heart disease (IHD) and of 26 subjects deceased by accidents or from causes other than atherosclerosis. Mg concentration in the fibrous and calcareous plaques, was significantly lower than in controls. The lowest Mg values were found in those who died by AMI. Calcium concentration, especially in the calcareous plaques, was enormous as against the controls. The four-seven times decreases of Mg/Ca ratio compared with the controls imply an alteration of the arterial wall cells. Magnesium deficit in the arterial wall probably plays a certain role in this process.

Adult↗
PubMed1995

Effect of cuprofilin on experimental atherosclerosis.

The effect of Cuprofilin, a newly synthesized C.(II)-chlorophyll complex, was assessed in rats with experimental atherosclerosis. The study was focused on changes in serum cholesterol, lipids, and triglycerides concentration as well as on serum and abdominal aorta Cu and Zn values. It has been ascertained that after 90 d in animals fed a rich lipid diet there was a statistically significant increase in serum cholesterol, triglycerides, and lipid concentration (p < 0.01). A significant augmentation of serum Cu values (p < 0.01) accompanied by a marked lowering of the same element in abdominal aorta (p < 0.01) was also found, as compared to the results registered in the control group. However, Cuprofilin, administered for 90 d in the group of animals with experimental atherosclerosis, significantly decreased the serum cholesterol, triglycerides, and serum lipid values (p < 0.01), increased copper content in aortic tissue (p < 0.01) and lowered serum copper concentration (p < 0.01) as compared to the untreated group. Moreover, in the aorta of administered animals the lipid infiltration has been demonstrated to be significantly diminished vs the untreated group.

Administration, Oral↗
PubMed1994

Concentration of copper, zinc, chromium, iron and nickel in the abdominal aorta of patients deceased with coronary heart disease.

The Cu, Zn, Cr, Fe, and Ni concentrations from the atherosclerotic plaques in the abdominal aorta obtained from 40 patients who died of coronary heart disease (CHD) were measured. In 32 of them the clinical and anatomical diagnosis was ischemic heart disease (IHD) and in 8 of them it was acute myocardial infarction (AMI). Concomitant determinations of the concentrations of the above trace elements were determined in 16 normal aortas from subjects who died in accidents or from causes other than atherosclerosis (C). The determinations were done by means of a Perkin-Elmer atomic absorption spectrophotometer, Model 300. The results are expressed in mg/kg of dried tissue. The Cu, Zn, and Cr concentrations were significantly lower (p < 0.01) in the atherosclerotic plaques of abdominal aorta of the deceased patients with IHD and AMI than in the control group. Iron had the tendency to rise but not significantly. The nickel level in the atherosclerotic plaques from abdominal aorta did not change significantly as compared to the controls. We attribute the low values of copper in the atherosclerotic aortic tissue in IHD and AMI to a shift of copper from aortic tissue into the blood. At present, there is no explanation for the low concentration of zinc and chromium in atherosclerotic aortic tissue.

Adult↗
PubMed1993

Effect of copper sulfate on experimental atherosclerosis.

Serum copper concentration increases significantly (p < 0.01) in rats with experimental atherosclerosis compared to a control group. The serum zinc, the zinc, and copper concentration in abdominal aorta and in liver decreases significantly (p < 0.05) compared to the control group. Administration of copper sulfate for 100 d in these animals induces a significant increase of serum copper (p < 0.01), decrease of serum cholesterol (p < 0.05) and increase of liver copper concentration as compared with the group fed only a high cholesterol diet. In the aorta of these animals the copper concentration increases and edema and lipid infiltration are considerably less than in the group of animals fed only a high lipid diet.

Animals↗
PubMed1992

Hypotensive drugs and the cellular energetic potential.

Clinical and experimental investigations have revealed changes of the Na, K, Ca and Mg concentration in serum and cells in patients with essential arterial hypertension (EAH). Some hypotensive drugs correct, more or less, the electrolytic abnormalities at the same time as the decrease of arterial pressure. Epidemiological studies have shown a lower arterial blood pressure in populations with decreased intake of Na and an increased intake of K, Ca and Mg. However the most frequently encountered electrolyte anomaly in patients with EAH is hypophosphatemia, mainly induced by a shift of inorganic phosphate from serum into the cells. Probably the increased influx of inorganic phosphate from the serum, increases the arterial cellular energetic potential. As hypotensive drugs lead to a reduction of the inorganic phosphate shift from serum into the cells one may suggest that the obtained decrease of arterial blood pressure may be at least partially due to a diminished energetic potential of certain cells.

Antihypertensive Agents↗
PubMed1991

[Doppler ultrasonic examination in assessing the outcome of the therapeutic method in patients with arteriosclerosis obliterans of the lower extremities].

The study included 62 patients with atherosclerosis obliterans of the lower extremities, of whom 47 in stage II, 5 in stage III and 10 in stage IV of the disease. In 22 patients were present single arterial obliteration, in 30 patients multiple, layered arterial obliterations, in 8 distal arterial obliterations and 2 a diffuse atherosclerosis of the lower extremities. Patients were examined in admission to the clinic, after the treatment performed at the clinic and at various intervals, during 2-4 years. The segmental arterial pressure, the pressure index and the ultrasonogram recorded with the Cardior electrocardiograph were followed-up. The arterial pressure and the pressure indices returned to normal values only after invasive procedures. The medical treatment can bring about the clinical regression and stabilization of the disease, as well as the improvement of the ultrasonogram. For the choice of therapeutic means, the pressure index is the best criterion, since it correlates with the severity of the disease. In the case of a pressure index 0.75, the medical treatment or the transluminal dilatation is preferred, whereas at an index of 0.7 the surgical revascularisation is considered necessary. Other ultrasonic parameters were also taken into account, such as the systolic passage time and the maximum velocity, which are less important in the attainment of the mentioned aims.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1990

Effect of clonidine on serum inorganic phosphorus in patients with essential arterial hypertension.

The decrease in arterial blood pressure in patients with essential arterial hypertension treated with clonidine is associated, in 88.9% of cases, with a rise in serum inorganic phosphorus. The increase of inorganic phosphorus in the serum of patients with hypophosphataemia, during clonidine therapy, is higher (P less than 0.001) than in hypertensive patients with normal values of serum phosphorus (P less than 0.01). This effect is more significant in overweight hypertensive patients (P less than 0.0005) than in normal weight hypertensives (P less than 0.02). No correlation was noted between the rise of serum inorganic phosphorus and the decrease in systolic and diastolic arterial blood pressure. The rise of serum phosphorus concentration in hypertensive patients is attributed to inhibition of insulin release and enhancement of growth-hormone secretion induced by clonidine.

Blood Pressure↗
PubMed1990

Hypophosphatemia in patients with essential arterial hypertension.

The concentration of serum inorganic phosphorus was determined in 162 patients with essential arterial hypertension (EAH) and in 71 control subjects. The serum phosphorus level was lower in patients with essential arterial hypertension than in the control subjects, and the differences were higher in the advanced stages of the disease. The lowest level of serum phosphate concentration was noted in overweight hypertensive patients, probably in relation to an enhanced insulin secretion. In control subjects the serum concentration of phosphate decreased with advancing age.

Adult↗
PubMed1989

Serum zinc and copper in patients with atherosclerosis and thromboangiitis obliterans.

The serum concentration of Zn and Cu were determined in 126 controls and 160 patients with atherosclerosis obliterans (AO) and 53 patients with thromboangiitis obliterans (TO). The concentration of serum Zn decreases with age both in controls and patients with AO in all the evolutive stages of the disease. In patients with TO, the concentration of serum Zn shows no correlation with age. The significantly lower values of serum Zn in controls and patients with AO over 61 yr than those below this age is attributed to the decreased Zn supply, especially to some individual cellular abnormalities. The values of serum Cu are higher in patients with AO and TO than in controls irrespective of the evolutive stage of the disease. This was related to cigarette smoking and inflammation. The Zn/Cu ratio in the serum is below 1 in patients with AO and TO and in controls over 61-yr-old. The pathogenetic role of this ratio in atherosclerosis and inflammation still remains a controversial question.

Adult↗
PubMed1987

Is urinary infection a risk factor for ischemic cerebrovascular disease?

The hypothesis is put forward that urinary infection is a risk factor for ischemic cerebrovascular disease (ICVD). Bacteriuria exceeding 10(5) units/ml actually occurred in 68% of the patients with ICVD while a similar number of bacteria was detected only in 12% of the age-matched control subjects. An increased concentration of circulating immune complexes was found in infected patients but the investigated hemostatic variables (plasma fibrinogen and factor VIII related antigen, platelet count and adhesiveness as well as dilute blood clot lysis time) did not significantly differ from patients with ICVD but no urinary infection. Although circulating immune complexes are able to cause endothelial lesions, further investigations on the hemostatic balance are required in order to substantiate the above mentioned hypothesis.

Antigen-Antibody Complex↗
PubMed1984

Serum concentration of Na, K, Ca, Mg, P, Zn and Cu in patients with essential arterial hypertension.

Serum concentration of Na, K, Ca, Mg and inorganic phosphate as well as serum levels of Zn and Cu were determined in control subjects and in patients with essential arterial hypertension (EAH) divided according to the stage of the disease. No significant differences were found between the serum mean levels of Na, K, Ca, Mg, Zn and Cu in controls and in patients with EAH. A significant decrease of the serum Zn was noted in the third stage of EAH. A number of cases with hypomagnesemia and/or hypopotassemia probably caused by a long term uncontrolled therapy was also detected. The concentration of inorganic phosphate was significantly lower in patients with EAH associated with overweight than in hypertensive patients with normal body weight and in controls. It is considered that a sustained study of the complex interrelationship between electrolyte interaction and the functional aspects of the arterial wall could still contribute to a better understanding of pathogenic aspects of EAH and of its complications including those subsequent to modern diuretic therapy.

Adult↗
PubMed1982

Increased level of the complement C3 protein in endogenous hypertriglyceridemia.

When compared to values obtained in normalweight, normolipidemic control subjects, the level of complement C3 protein and total complement activity (CH50) were found to be obviously decreased in patients with decompensated cirrhosis of the liver and slightly but significantly increased in subjects with type IIb and type IV hyperlipoproteinemia. C3 protein level was positively correlated with the concentration of serum cholesterol, the logarithm of serum triglyceride concentration, serum pseudocholinesterase and total complement activity. There were no significant differences concerning C3 protein level between hyperlipidemic subjects with clinical atherosclerosis and those without documented vascular disease. It is suggested that accelerated lipoprotein turnover occurring in many subjects with type IIb and type IV hyperlipoproteinemia might enhance the synthesis of several liver produced plasma enzymes and proteins including the C3 protein of the complement system.

Adult↗
PubMed1982

Effect of propranolol on hypophosphatemia in overweight.

A negative correlation was found in 54 hypertensive overweight patients between the excess body weight and the level of serum inorganic phosphorus. The effect of propranolol upon the serum concentration of phosphorus, sodium, potassium, calcium and magnesium in 20 of the above mentioned patients as well as in five normal weight, normotensive subjects was studied. After 10 d of treatment with propranolol (160-240 mg/24 h) the concentration of serum phosphate rose from 0.76 +/- 0.02 mmol/l to 0.98 +/- 0.06 mmol/l (P less than 0.02) in the 20 overweight hypertensive patients and remained unchanged in the five control subjects with initial normal phosphate levels. No propranolol induced changes of other serum electrolytes was noted. There is no obvious explanation of the above mentioned findings. An increased uptake of glucose and inorganic phosphate by the enlarged adipose tissue and an impairment of this mechanisms by propranolol might be however suggested.

Adult↗
PubMed1977

Guancydine, a new hypotensive agent with complex action.

Guancydine (1-cyano-3-tert-amylguanidine) lowered within normal limits the tensional values in an interval of four hours after its administration in eight out of nine hypertensive patients under experiment. The hypotensive effect of a single oral dose of 500-750 mg persists for about 6-7 hours after its administration. Guancydine does not impair the vasopressor response to angiotensin II but reduces the action of this peptide on the excretion of water, Na, K and Ca through urine. The hypotensive effect of Guancydine is associated with a decrease of platelet adhesiveness and an activation of fibrinolysis. In view of this fact, Guancydine might play a role in the prophylaxis of complications of arterial hypertension - atherosclerosis and trombosis. The increase of venous blood oxygenation after Guancydine could be attributed to the opening of arterio-venous shunts or to the reduction of tissular extraction of oxygen. Guancydine does not seem to be toxic. It produced, in some patients, slight headache and orthostatic hypotension, especially during the first hours after administration.

Adult↗
PubMed1975

Effect of angiotensin II upon platelet adhesiveness and the thrombelastogram in patients with essential arterial hypertension.

Platelet adhesiveness increases significantly after angiotensin II administration, in pressor and subpressor doses, only in the hypertensive patients with urinary infection. The k index on the thrombelastogram decreases significantly following angiotensin II infusion in pressor doses both in the hypertensive patients with urinary infection and in those without urinary infection. At the same time, angiotensin II infusion in pressor and subpressor doses determines a significant increase of epsilon index in both hypertensive patients with urinary infection and in those without urinary infection. These results pose the problem of thrombocyte sensitization by the urinary infection to the vasopressor substance. The increased tendency to thrombosis by angiotensin, in hypertensive patients with urinary infection, could constitute a mechanism of malignant transformation of arterial hypertension.

Adult↗