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Biomedical subjects

G V Goldobenko

Publications and source records attributed to G V Goldobenko.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Preoperative hypoxia-radiotherapy in multimodal treatment of patients with stage III colonic cancer].

The paper analyzes the results of surgical and multimodality therapies for 237 patients with Stage III colonic cancer, which were divided into 3 groups. Group 1 included 119 patients undergone only surgical management, Group 2 comprised 43 who were additionally treated with intensive radiation (4 Gy daily for 5 days) and Group 3 consisted of 75 patients who were irradiated in the presence of overall hypoxia evoked by breathing a gaseous mixture containing 9% oxygen. A five-year follow-up has indicated that there are significantly higher survival rates among those who have received a multimodality therapy rather than those merely operated on (82 +/- 5 and 53 +/- 9%, respectively). A short-term gaseous hypoxia has been found to reduce the incidence of systemic radiation reactions in patients during preoperative radiation and to fail to lower the efficiency of multimodality therapy.

Colonic Neoplasms↗
PubMed1994

[Definition, classification and combined treatment of locally invasive rectal neoplasms].

From analysis of 490 case records of patients with stage IV A rectal carcinoma, 3 groups of patients were distinguished according to the size of the tumor and the degree of its fixation to the surrounding tissues and growth into the adjacent organs. Such locally spread tumors of the rectum must be subjected to combined treatment: preoperative large-fractional radiotherapy in concurrent local SHF-hyperthermia followed by operation 24-48 hours later. If resectability of the tumor is doubtful, a relieving colostoma is formed in the first stage and distance gammatherapy is applied in a dose of 4 Gy twice a week to a total dose of 32 Gy auring medication with metronidazole and local SHF-therapy. Concurrent intraarterial chemotherapy with 5-fluorouracil (15 mg/kg body weight) has been lately introduced into practice in the treatment of such patients. The results of this complex treatment are evaluated 3-4 weeks after the course is completed.

Combined Modality Therapy↗
PubMed1992

[The possibilities for organ-preserving treatment in retinoblastoma in children].

One-hundred pediatric patients with uni- and bilateral retinoblastoma (140 tumors on the whole) received a combination of radio- and chemotherapy. Radiation was delivered by gamma-ray units and an electron accelerator. The single and total focal doses used were 1.5-2.0 Gy and 40-55 Gy, respectively, depending on tumor stage. Simultaneously, chemotherapy with vincristine, cyclophosphamide and adriamycin were given intravenously in standard doses. As a result, 85 out of 95 (89.5%) children including 43 cases of bilateral tumor are alive. Partial response or no change were registered in 72 tumors (51.4%). Progression was observed in 28 tumors (20%) at the average of 6-8 months following the start of treatment. Forty tumors (28.6%) responded completely, with remissions lasting for a follow-up period of 2-6 years. Not a single case of organ-sparing surgery developed distant metastases. To summarize, a combined treatment modality for retinoblastoma according to TNM stage was developed and indications for organ-sparing surgery outlined. The standard treatment modality for bilateral retinoblastoma was revised.

Child, Preschool↗
PubMed1991

[Prospects of the use of modifiers in children's oncologic radiology].

Problems of radiotherapy of malignant tumors in children are discussed. The treatment included the use of different radiation modifiers with the aid of which radiosensitivity of normal and tumorous tissues may be selectively altered, thereby reducing radiation load of normal tissues and organs adjacent to the tumor. The data are given on the treatment of 45 children with soft tissue sarcomas. In these children, radiotherapy was carried out in combination with local microwave hyperthermia.

Child↗
PubMed1991

[Radiotherapy of malignant tumors in children].

Radiation treatment is widely used in pediatric cancer patients. Much attention should be paid to preserve the function and structure of normal organs and tissues adjacent to tumor. To achieve this goal, optimal treatment modality should be chosen and closely followed. Certain peculiarities of irradiation of children, particularly, infants should be considered. These include the use of medication sleep. Drug combinations to be used to prepare patients for radiotherapy are discussed.

Age Factors↗
PubMed1991

[The thermoradiotherapy of malignant salivary gland tumors].

The paper is devoted to the discussion of problems of the effectiveness of thermoradio- and radiotherapy of patients with locally advanced malignant tumors of the salivary glands. The 1st group of 14 patients received gamma-beam therapy, and the 2nd group of 32 patients was given radiotherapy combined with local microwave hyperthermia. After delivering a dose of 40 Gy a decrease of a tumor size by greater than 50% was noted in 50% of the patients of the 1st group and in 76% of the patients of the 2nd group. Thermoradiotherapy prove to be most effective in patients with adenoid cystic carcinoma, tumor regression over 75% was noted in half of them. Complications in thermoradiotherapy were unnoticed.

Combined Modality Therapy↗
PubMed1991

[Radiation treatment of bladder cancer using different fractionation regimens].

The paper is devoted to a follow-up of 177 bladder cancer patients. The problems of providing radiotherapy with the use of hyperfractionation of a radiation dose were discussed. Despite an increase in a tumor dose by 15%, no increase in the number and expression of local radiation reactions is observed. Enhanced therapeutic efficacy was observed, particularly in cases of locally advanced tumors (T3). Three years after conventional radiotherapy 44% of the patients were alive, after hyperfractionated irradiation--69%.

Adult↗
PubMed1990

[The absorbed dosage and its fractionation in the radiation treatment of tumors in children].

Radiation therapy is widely used in pediatric oncology. Its use emphasizes the problems of the protection of growing tissues and organs. The paper is concerned with the problem of effective distribution of an ionizing radiation dose delivered to a locally advanced tumor in children. Analysis of the literature and authors' data show that the growing organs of a child are 2-2.5-fold more sensitive than the same organs of an adult. Besides some organs and tissues at various ages of a child possess a various degree of maturity. Therefore it is proposed that small single doses (0.6-1 Gy) that can be delivered 2-3 times a day, should be used in pediatric oncology. A scheme of dynamic irradiation of radiosensitive and resistant tumors of children was prepared and tested under clinical conditions.

Child↗
PubMed1989

[Use of preoperative intensive irradiation in the combined treatment of patients with colon cancer].

The paper discusses the results of preoperative intensive irradiation used in combined treatment for cancer of the sigmoid colon. Diagnosis was verified morphologically. Patients were randomly assigned for irradiation+surgery (group 1-97 cases) or surgery alone (group 2-111). Those undergoing radical operations only (in both groups) were included into the analysis. No difference was found between the two groups in rate of postoperative complications development (frequency of intestinal anastomosis failure included). The frequency of recurrence and metastasis development was significantly higher in the surgery only group. In patients with metastasis into regional lymph nodes, five-year survival was significantly higher among those who had undergone irradiation.

Adenocarcinoma↗
PubMed1989

[Evaluation of 5-year results of the scheduled treatment of lymphogranulomatosis in children].

A total of 186 children and adolescents aged 2.5 to 16 years with Hodgkin's disease were placed under observation. According to the accepted classification (Ann Harbour, 1971) they were divided into two groups. Exploration laparatomy was applied in the first group of the patients (n-103) as the final diagnostic stage in order to verify the pathomorphological stage of the process. In the second group (n-83) the clinical stage of the disease was only appraised. The pathological foci beneath the diaphragm were discovered, however, with the aid of ultrasonic tomography of the abdominal cavity, scanning with gallium-67 citrate, and computer-aided tomography. The latter technique was employed in case of controversies in the interpretation of the foci of lesion with the aid of the first two diagnostic methods. It is concluded that in view of the high tempo of the so-called silent generalization and dissemination of Hodgkin's disease in children, this condition should be regarded in childhood as a potentially systemic process. With such an attitude towards Hodgkin's disease in children it is advisable to abandon exploration laparotomy with splenectomy depriving the patient of the massive depot of humoral (B cell) immunity and creating the danger of an aggressive course of intercurrent infections in splenectomized children affected with Hodgkin's disease. In the choice of the initial treatment which provides the basis for obtaining the highest effect, preference should be given to polychemotherapy. It is indicated in the presence of "biological activity" of the process, general symptoms, generalization and dissemination of the process (stages III and IV), and in the presence of multiple foci in stage II.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Ambulatory radiation therapy of malignant tumors in children].

The potentialities of outpatient radiotherapy for pediatric solid tumors were studied in 41 such cases. Gamma teletherapy was given from a Rokus installation. Radiation treatment was expected to induce serious complications in patients with the involvement of blood vessels, hollow organs and vertebra, the said side-effects requiring inpatient management. Outpatient radiotherapy is indicated mostly in the postoperative period. Thanks to a transfer of 41 cases to outpatient treatment, another 23 primary pediatric patients could be admitted to hospital.

Adolescent↗
PubMed1989

[The prognostic significance of the rate of growth in the radiation treatment of esophageal cancer].

Biological growth parameters (tumor volume, doubling time with regard to a tumor site, a macroscopic type of tumor growth and semiregression time in radiotherapy or in its combination with radiomodifying agents) were analyzed in 180 esophageal cancer patients. Immediate and short-term results of therapy were shown to be in direct relation to the above factors. The most favorable prognosis is to be expected in the group of patients with fast growing tumors (doubling time less than or equal to 64 days) Unless a tumor of the esophagus has become large (a tumor volume not more than 68.6 cm3), it means exophytic or mixed growth, and radiotherapy is recommended in combination with radiomodifying agents, first of all with local hyperthermia.

Combined Modality Therapy↗
PubMed1989

[Prognosis and results of radiotherapy of esophageal cancer with the use of radiomodifiers].

The paper is concerned with a retrospective analysis of the results of therapy of 277 esophageal cancer patients who received radiotherapy alone or in combination with radiomodifying agents depending on the results of clinico-instrumental investigations. Correlation of immediate effectiveness of radiation therapy and duration of a case history, macroscopic type of growth of a tumor, its dissemination, a degree of tumor regression at a dose of 35-40 Gy, the frequency and severity of radiation esophagitides was confirmed. A degree of the influence of these factors was less marked in the use of radiation therapy combined with radiomodifying agents. Life duration is proportional to a degree of tumor regression achieved by the end of a radical course of radiation therapy.

Carcinoma, Squamous Cell↗
PubMed1988

[Combined treatment of malignant kidney tumors].

The paper is devoted to the discussion of the results of combined therapy of 79 patients with malignant renal tumors. Eight patients underwent nephrectomy and postoperative irradiation at a mean dose of 28 Gy, a marked radiation reaction was noted in 3 of them, and irradiation had to be discontinued. All 8 patients died within 3 yrs. of a follow-up period. Thirty patients received preoperative irradiation at a single focal dose of 2-2.5 Gy and a summary dose of 30-50 Gy 3-4 weeks before nephrectomy. A dose of 30 Gy did not result in tumor reduction, a dose of 40 Gy led to an insignificant reduction of a tumor size by 1-2 cm, tumor resorption by 30-50% was noted at doses of 50-60 Gy. Thirty-eight patients were given preoperative irradiation at a daily single focal dose of 4 Gy and a summary dose of 20 Gy, followed by nephrectomy in 24-48 h. Radiation reactions in preoperative irradiation were less marked than in postoperative irradiation. The 3-year survival rate in preoperative irradiation and nephrectomy was 72.5%, the 5-year survival rate was 53.2%. A fractionation type did not influence the survival rates.

Adult↗