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Biomedical subjects

G V Goldobenko

Publications and source records attributed to G V Goldobenko.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Hyperthermia in combined radiotherapy of cancer of the mouth mucosa].

Combined treatment of patients with cancer of the oral mucosa using a dynamic course of irradiation in combination with local hyperthermia was proposed. Altogether 55 patients were treated, of them in 51 (92.7%) complete tumor regression was achieved. The short-term results were indicative of the efficacy of the above method.

Adult↗
PubMed1987

[Diagnosis and treatment of cancer of the skin of the perianal region].

Clinical course, diagnosis and treatment of 14 cases of perianal skin carcinoma are discussed. Perianal skin cancer is a rare disease with a specific clinical course. Radiotherapy is the treatment of choice. A combination of irradiation and microwave hyperthermia proved to be the best therapeutic option. All patients who had received proper treatment survived 5 years.

Adult↗
PubMed1987

[Experience with thermoradiotherapy of malignant tumors].

The authors analyzed immediate, short-term results of thermoradiotherapy of 112 patients and radiotherapy alone of 91 patients (control group). All had tumors of different sites. Local hyperthermia used as an adjuvant to radiotherapy made it possible to increase the frequency of complete tumor regression from 0 to 11% in rectal cancer patients, from 86 to 100% in head and neck cancer patients, from 0 to 14% in the patients with soft tissue sarcomas and from 40 to 71% in children with rhabdomyosarcomas. These results suggest a possibility of raising the efficacy of radiotherapy combined with local electromagnetic hyperthermia.

Adolescent↗
PubMed1987

[Repeated irradiation of recurrent head and neck tumors using hyperthermia].

The authors presented an analysis of immediate and short-term results of therapy of 115 patients on thermoradio- and chemotherapy for recurrent head and neck tumors. Triple irradiation at single focal doses of 10 Gy at one-week intervals between fractions were employed taking into account radioresistance of recurrent tumors. After each session of irradiation the patients received polychemotherapy (cyclophosphamide, vinblastine, methotrexate) for 2 days. Local MWF-hyperthermia was provided before a session of irradiation and during drug administration. Complete or partial tumor regression was noted in 94% of the patients with the resultant improvement in their general status. The 3-year disease-free interval was noted in 41% of the patients. Radiation changes were restricted to atrophy of the skin and mucous membranes and stable disorders of salivation.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[Immediate results of hypoxiradiotherapy of malignant tumors].

The paper represents a comparative analysis of hypoxiradiotherapy of 202 patients with malignant tumors of different sites. A significant decrease (a 3.5-fold) in the number of severe local radiation reactions was noted in hypoxiradiotherapy of cancer of the esophagus, pancreas and metastases of seminoma to the retroperitoneal lymph nodes. A decrease in the number and intensity of general radiation reactions and the absence of pyo-inflammatory complications after radical operations were noted in preoperative large fractionated hypoxiradiotherapy of colon and lung cancer. The general number of radiation reactions was 12% less in hypoxiradiotherapy. Tumor regression after hypoxiradiotherapy did not slow down. Complete or considerable tumor resorption after irradiation against a background of gaseous hypoxia was noted in 74 +/- 7% of the patients and in 65 +/- 7% after radiotherapy alone. Hypoxiradiotherapy alone or before operation should be widely introduced into clinical practice of cancer dispensaries or radiological departments.

Adult↗
PubMed1986

[The use of artificial hyperglycemia in the radiotherapy of patients with rectal cancer].

A treatment modality employing radiotherapy with subsequent hyperglycemia induction was evolved in experiments on mice and then clinically tested in 32 cases of inoperable locally--extensive primary and recurrent cancer of the rectum. A 50% regression of tumor was registered in 14 (43.0%) out of 32 patients treated with radiotherapy in combination with hyperglycemia. Similar degree of regression was observed only in 6 (15.0%) out of 40 patients who received the same radiation treatment unaccompanied by hyperglycemia. The difference was statistically significant. No untoward side--effects developed. The results are encouraging and seem to open up new vistas of clinical research.

Adenocarcinoma↗
PubMed1985

[Hyperthermia and hyperglycemia in the radiation and combined treatment of locally disseminated and recurrent rectal cancer].

The results of the use of short-term induced hyperglycemia and local UHF-hyperthermia in radiation therapy of 27 rectal cancer patients aged 17 to 65 were analysed. A primary inoperable locally disseminated tumor process was noted in 8 patients, recurring cancer in 19. A noticeable tumor regression (over 50%) was observed in 7 out of 8 patients making a radical operation possible. With computerized tomography tumor regression was recorded by over 50% in 9 out of 19 nonoperated patients. The data obtained illustrate some potentialities of raising the efficacy of radiotherapy using radiomodifiers.

Adenocarcinoma↗