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G V Goldobenko

Publications and source records attributed to G V Goldobenko.

85 records · Page 5Linked to original sources
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[Hyperthermia as a method for treating prostatic adenoma].

Local microwave hyperthermia was used in 15 patients aged 60 to 76 years with prostatic adenoma on an inpatient (n = 8) and outpatient (n = 7) basis. Severe clinical symptoms of prostatic adenoma was considered indication and urinary and prostatic stones were contraindications. Every patient received 6 hyperthermia treatments (41 to 42 degrees C) with a 915 or 460 MHz device. Adenoma of the prostate was treated twice a week. An interval of 3-4 days was used to avoid thermic tolerance. The treatments were well tolerated. Prostatic size was reduced by 15.2 cm2 in 11 patients and unchanged in 1 patient. Three patients required surgery 2 weeks after treatment withdrawal because of adenoma distension with residual urine and 3 patients were operated on for cystostomes. The overall effect of microwave hyperthermia on prostatic adenoma was induction of focal sclerosis in adenoma. This treatment improved uroflowmetric findings and abolished residual urine. Hyperthermia is a reasonably safe conservative option for inoperable patients with prostatic adenoma.

Aged↗
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[Radiation exposure and local hyperthermia in the treatment of prostatic cancer].

During the recent two decades, radiation therapy has become a major intervention for prostatic cancer, especially in patients without remote metastases. Most recently local hyperthermia has been recruited for selective potentiation of radiation effects on the tumor. This study involved 81 patients with the prostatic cancer T2-4NxM0. All patients had adenocarcinoma of variable malignant potential. Group 1 (n = 24) received only megavoltage radiation therapy while Group 2 (n = 57) was additionally treated with local microwave hyperthermia. A Yalik-F device (USSR) with electromagnetic frequency 460 MHz was used. Special intracavitary irradiating aerials were designed and employed. While symptoms of neoplasia are lacking 2 years following radiation therapy in 13 of 24 patients of Group 1, this response was obtained in 10 of 12 patients of Group 2 (54 +/- 5% and 83 +/- 10%, respectively). Two-year survival rates after radiation and thermoradiation therapy were 81 +/- 8% and 92 +/- 8%, respectively. Asymptomatic progress is seen in 40 +/- 10% and 75 +/- 12% of the patients. These results suggest that local hyperthermia as an adjuvant to radiation therapy will improve the efficacy of therapy in patients with prostatic cancer.

Adenocarcinoma↗