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Biomedical subjects

G V Goldobenko

Publications and source records attributed to G V Goldobenko.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Combined treatment of colon cancer with intensive preoperative irradiation].

The paper is concerned with the results of a randomized study of surgical and combined treatment of colon cancer patients using intensive preoperative irradiation; 102 were operated upon, 43 received combined treatment. It was shown that preoperative treatment did not raise the number of complications. Combined treatment made it possible to reduce the frequency of recurrences improving the 3-year survival rates.

Adult↗
PubMed1985

[Radiotherapy in the multimodality treatment of retinoblastomas in children].

The results of multimodality therapy of 50 children with uni- or bilateral retinoblastoma were assessed. Gamma-beam therapy with the application of a special protective collimator and polychemotherapy were used as modalities supplementing eye extirpation. Some patients were irradiated prior to operation, the others following it. Despite a slight decrease in a tumor radiation dose in the first group, 2-year survival rates in both groups were the same. Of 32 patients 30 (94%) in both groups have been alive for 2 yrs. without signs of disease after multimodality therapy. Patients with Stage I retinoblastoma were subjected to chemo- and radiotherapy; 16 out of 18 patients have been alive for 2 yrs. It has been stressed that radiation therapy is an important component in multimodality therapy. It can be used as a modality of the combined method of tumor surgical removal or as a method of radical therapy in early forms of the disease.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Aspects of the preoperative radiation therapy of patients with rectal and colonic cancer].

The authors present some data on 288 patients with colonic and rectal cancer who were given preoperative radiotherapy, and on 145 patients with rectal cancer who underwent surgery only. In operable rectal cancer intensive irradiation at a single focal dose of 6.5 Gy and summary dose of 19.5 Gy (3 daily fractions), in operable colonic cancer 4 and 20 Gy (5 daily fractions respectively). The five-year survival rate attained during combined treatment of rectal cancer exceeded that after radical operations by 30%. Fractional-extended irradiation at a single focal dose of 4 Gy and summary dose of 40 Gy (every other day) in 44.6% of the patients permitted one to make locally disseminated rectal cancer resectable. Preoperative irradiation of locally disseminated rectal cancer with a preliminary synchronization of the tumor cell division cycle with 5-fluorouracil (a single focal dose of 6 Gy, summary dose of 36 Gy for irradiation twice a week) was well tolerated by the patients, and its effect on tumors was more noticeable as compared to radiotherapy only. Marked radiation reactions were absent in colonic cancer, radical operation (hemicolectomy) entailed no additional difficulties. Local recurrences were not noted in either of 10 patients who had been followed-up in the course of 1 year.

Colonic Neoplasms↗
PubMed1983

[Procedure and results of combined radiation and surgical treatment of laryngeal cancer patients].

The paper is concerned with the results of a study of 250 patients with laryngeal cancer who received a radical course of radiation therapy. The 1st stage of the disease was diagnosed in 15 (6%) patients, the 2nd stage in 47 (18.8%), the 3rd in 178 (71.2%) and the 4th in 10 (4%) patients. gamma-Beam therapy was given to 158 patients, electron therapy to 60, and electron therapy combined with 5-fluorouracil to 32 patients with stages III--IV. The patients were irradiated on a B-5M-25 betatron and gamma-units of the rokus type. A single focal dose was 3 Gy, the summary dose in most of the cases 60-70 Gy (TDF 99-115 units). Therapeutic results were evaluated by the degree of tumor regression, frequency of recurrence and the survival of patients without evidence of disease. The short-term results for all types of treatment were almost the same. However in cancer of stages I--II a complete tumor resorption was noted more frequently than in tumors of stages III--IV (respectively 81 and 36%). Differences in the frequency of a complete tumor regression also depended on its site. It was observed in 62% of the patients with the supraligamentous tumor site, in 93% with the ligamentous site and in 45% with the supraligamentous-ligamentous site. A study of the long-term results of the treatment of patients with laryngeal cancer has shown that a 5-year disease-free survival with good organ function is noted in 81% of the patients with stages I--II and only in 28% with stages III--IV. The results do not depend on the method of irradiation.

Adult↗
PubMed1979

[Remote results of preoperative large fractionation gamma-therapy for breast cancer].

The results of using large fractionation irradiation preoperatively in 131 breast cancer patients are reported. A focal dosage for a primary tumor was found to be 2400 rad (1350 ret) and 1800 rad (1100 ret) for axillary lymph nodes, which given by 600 rad in a day neither effect the course of surgical intervention nor increase the number of the postoperative complications. A five-year cure with stage I-II was 66,3 +/- 11,1%, with stage III--47,9 +/- 7,3%. The whole course of radical treatment lasted on the average for 41-46 days.

Adult↗