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Biomedical subjects

G V Grudtsyn

Publications and source records attributed to G V Grudtsyn.

At least 19 recordsLinked to original sources
PubMed1989

[The nature of changes in central hemodynamics and myocardial contractile capacity of the left ventricle during volumetric loading in patients with chronic alcoholism in relation to the duration of alcohol abuse].

Forty patients aged 33 to 66 years suffering from chronic alcoholism, stages II-III, were examined. All the patients were subjected to contrast ventriculography before and after exercise test to identify the latent forms of heart failure. According to the coronarography findings, 9 out of the 40 patients demonstrated the signs of atherosclerotic injury to the coronary arteries. The data of endomyocardial biopsy of the left ventricle have shown morphologic changes characteristic of alcohol-induced heart injury, namely atrophy of cardiomyocytes, fat deposition in the interstitium, lysis of myofibrils, appearance of large vacuoles in cardiomyocytes, and mitochondriosis.

Adult↗
PubMed1989

[Functional status of the heart conduction system and myocardial contractility in patients with alcoholic heart damage].

33 patients with alcoholic heart damage (AHD) were studied. The diagnosis was based on clinical symptoms of chronic alcoholism, roentgenocontrast coronaroangiography and ventriculography (in some cases with endomyocardial biopsy), echocardiography, bicycle exercise test and on exclusion of other cardiovascular diseases. In all the patients intracardiac electrophysiological study was performed. Younger persons systematically abusing alcohol and having no pronounced clinical picture of cardiovascular damage exhibited symptoms of functional conduction disturbances located mainly in ventricular conduction pathways and AV-node and more rarely in the sinus node and His-Purkinje's system. AHD in younger persons could have 2 different clinical courses. 1) with prevailing damage in conductive structures; 2) with prevailing damage of contractile myocardium.

Adult↗
PubMed1989

[Atrial fibrillation in alcoholic lesion of the heart].

Sixty chronic alcoholic patients, aged 35.6 +/- 0.7 years and an average alcoholic history of 9.3 +/- 0.5 years were examined. Atrial fibrillation was detected at 24 h ECG monitoring in 2 (3.45%) patients, and paroxysms of atrial fibrillation or flutter were detected by intracardiac electrophysiologic investigation in 6 (22.2%). Fourteen (44.8%) patients with alcoholic heart damage demonstrated atrial vulnerability, indicative of a predisposition to atrial fibrillation even at earlier stages of alcoholic heart damage.

Adult↗
PubMed1988

[Volumetric load in the diagnosis of early right-ventricular heart failure in patients with alcoholic heart damage].

Coronaroventriculographic data are presented for 32 patients with alcoholic heart damage (AHD). Volumetric load (400-450 ml polyglucin administration) was used to detect preclinical heart failure. Coronarography demonstrated atherosclerotic coronary arterial lesions in 7 of 32 patients. A comparative assessment of central hemodynamic and right-ventricular myocardial contractility parameters in the patients and control subjects showed that the ejection fraction was reduced in AHD patients because of a significant increment of end diastolic and end systolic volumes as well as significantly reduced right-ventricular stroke index. Repeated ventriculography after volumetric stress showed significantly increased volumes and reduced ejection fraction that were indicative of latent right-ventricular heart failure.

Adult↗
PubMed1988

[Total and regional myocardial contractility of the right ventricle during a volumetric loading test in patients with an alcoholic heart lesion].

The authors presented the results of right contrast ventriculography with a volumetric exercise test in patients with alcoholic heart affection. An increase in right ventricular end-systolic and diastolic volumes (most of the former), a decrease in the ejection fraction in response to an increase in the right ventricular end-diastolic pressure were noted during the test. A diffuse decrease in right ventricular regional (segmental) contractility in the absence of zones of akinesia or local contractility disorder was also revealed.

Adult↗
PubMed1988

[Diagnostic value of diurnal ECG monitoring, the bicycle exercise test and intracardiac electrophysiological study in the detection of arrhythmia in patients with alcoholic lesions of the heart].

Altogether 53 patients with stage II chronic alcoholism were investigated to study the diagnostic significance of circadian ECG monitoring (CECGM), bicycle ergometry (BEM) and intracardiac electrophysiological investigation (EPI) in the detection of arrhythmias. The results obtained suggested that the most informative method of diagnosis of paroxysmal arrhythmias in patients with alcoholic cardiac lesions was EPI with which arrhythmical paroxysms were detected in 29.6%, whereas CECGM and BEM turned out diagnostically significant in 7.4%. Occult arrhythmical paroxysms were detected for the first time using EPI of the heart.

Adult↗
PubMed1987

[Clinical characteristics of the initial stage of alcoholic lesion of the heart in periodic and systematic forms of alcohol consumption].

A combined study of patients with second- or third-stage chronic alcoholism, prone to drinking bouts or regular alcohol consumption, was carried out to evaluate the clinical course of an early stage of alcoholic heart damage (AHD). The AHD patients with second- or third-stage chronic alcoholism and periodic alcohol consumption typically exhibited recurrent chest pains, heart rhythm disorders, signs of heart failure after an alcoholic bout, and those given to regular drinking had somato-vegetative complaints.

Adult↗
PubMed1986

[Rhythm and conduction disorders in alcoholic lesions of the heart].

Combined investigation (bicycle ergometry, daily ECG monitoring, electrophysiologic studies, coronarography and ventriculography) in 46 alcoholic patients established ventricular extrasystole, paroxysmal atrial fibrillation, atrioventricular block as well as reduced ejection fraction and increased end systolic ventricular volume in the majority of those. Daily ECG recording, bicycle ergometry and electrophysiologic studies proved to be particularly sensitive in detecting cardiac arrhythmias in the alcohol-damaged heart.

Adult↗
PubMed1986

[Angiographic study of left and right ventricular function in patients with alcoholic lesions of the heart and dilatational cardiomyopathy].

An angiographic study of left- and right-ventricular function in 57 patients with alcoholic heart and dilatation cardiomyopathy demonstrated preclinical disorders of left-ventricular myocardial contractility and more marked right-ventricular changes in patients with second-stage chronic alcoholism. In cases of dilatation cardiomyopathy, left-ventricular dysfunction was predominant, while right-ventricular changes were less pronounced.

Adult↗
PubMed1986

[Features of the heart conduction system in alcoholic lesions of the myocardium].

An electrophysiologic functional study of the atrial conductive structure, the atrioventricular junction, the His-Purkinje system in 33 patients with second-stage chronic alcoholism showed impaired cardiac conduction through the atrioventricular node and, less commonly, the His-Purkinje system, to be the principal manifestation of alcoholic heart damage.

Adult↗