[Atrial stimulation test in the diagnosis of the early stages of myocardial contractile failure in ischemic heart disease].
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Biomedical subjects
Publications and source records attributed to G V Grudtsyn.
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A total of 75 patients with proved weak sinus node syndrome (WSNS) were examined. In many cases, WSNS was found to accompany cardiovascular diseases, such a coronary disease, myocarditic cardiosclerosis and essential hypertension. Sinus node dysfunction is often combined with signs of disorder in other departments of the hearts conductive system. A screening for WSNS should incorporate a combination of diagnostic procedures, of which Holter's ECG monitoring and electrophysiological investigation of the heart's conductivity are the most reliable and informative.
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It is shown on the basis of retrospective appraisal of the course of ischemic heart disease in 235 patients hospitalized for acute macrofocal myocardial infarction that 78% of them had a prodromal period. The prodromal symptoms corresponded to those registered by WHO as preinfarction state. It was also shown that stable ischemic changes in the ECG during dynamic examination are of vital importance in the diagnosis of a preinfarction state. Problems of the medical tactics employed in the prodromal period of acute myocardial infarction are discussed.
The efficacy of electroimpulsive therapy with low energy discharges (up to 50 joules) in various paroxysmal arrhythmias was studied. A mild tranquilizer, seduxen (diazenam), was used as the anesthetic. Electroimpulsive therapy with low-energy discharges was found to produce a high effect in ventricular tachycardia and atrial flutter but a poor restorative effect in atrial fibrillation. The possibility of successful anesthesia with seduxen in electrical cardioversion of paroxysmal disorders of cardiac rhythm is concretized.
Visken (prindolol) was used in 42 patients. Its hypotensive effect was studied by the double-blind method. The hypotensive effect was encountered in 34 patients. With the administration of a placebo the arterial pressure became elevated, while after repeated prescription of the drug it again decreased significantly. Study of hemodynamics by radiocardiography in 18 patients treated with prindolol revealed no essential changes in the cardiac output, total peripheral resistance, rate of venous blood flow and volume of circulation.
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Under observation were kept 80 patients with signs pointing to the sick sinus syndrome. Most of them suffered from ischemic heart disease, from atherosclerotic cardiosclerosis and acute myocardial infarction. Persistent sinus bradycardia with active and passive heterotopic arrhythmias were recorded in 42 patients. Sino-auricular block of the II and III degrees or asystolia of the atria with ectopic arrhythmias were observed in 37 cases. A number of patients displayed fibrillary bradyarrhythmia, extrasystole with post-extrasystolic depression of the rhythm and other disturbances. The so-called tachycardia-bradycardia syndrome characterized by the presence of tachycardiac arrhythmias occurring against the background of a marked bradycardia was registered in 25 persons. Fifteen patients demonstrated attackes of the Morgagni-Adams-Stokes syndrome, usually associated with lengthy periods of cardiac asystole. The treatment of ectopic arrhythmias in patients with the sick sinus syndrome presents considerable difficulties, but in many of them these disorders could be successfully eliminated by a careful and rigidly controlled application of antiarrhythmic agents (isoptin, ajmalin, pulsnorma, rhythmodan, beta-adrenergical blocking agents). For some patients exhibiting a tendency toward asystole electric stimulation of the heart is indicated.
Cardiac rhythm disorders called atrioventricular dissociation, especially the so-called dissociation with interference have been causing controversy among the cardiologists for a long time. The latter term implies an independent activity of the atria and ventricles, that is in no way connected with an orthograde atrioventricular block, and that develops in the presence of intermittent normal conductivity of sinus impulses. This disorder is always of a secondary nature and it may be due to the disorders in the formation of the primary rhythm, or conductivity of the impulse (passive form), or acceleration of the secondary rhythm (active form). The causes of such atrioventricular dissociation may lie in sinus bradycardia, sinoauricular or incomplete atrioventricular block, compensatory pauses after extra-systoles, atrioventricular and ventricular tachycardia (paroxysmal or nonparoxysmal) with a retrograde atrioventricular block, etc. Examples of ECG patterns illustrating most of the above mechanisms are presented. Due to the existence of several mechanisms that cause atrioventricular dissociation, and due to the fact that individual authors imply different meanings by the term "interference", it seems reasonable to abandon the term "dissociation with interference". In such case it would seem more appropriate to call the state a primary rhythm or conductivity disorder indicating an incomplete atrioventricular dissociation for a proper choice of therapy.
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