The regional rule for bacterial base composition.
If one looks at the composition of coding DNA and of three types of intergenic regions--those between convergent, parallel and divergent genes--a striking pattern is seen in a wide range of bacteria. The AT-content of coding sequence is lowest, and the AT-contents of the intergenic regions increase in the order: convergent, parallel and divergent. Why does this pattern occur? In this article, I suggest an explanation based on the structural requirements for the binding of transcription factors.
Bacteria↗