Biomedical subjects
Publications and source records attributed to H A Adams.
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OBJECTIVE: To evaluate the effect of the non-steroidal anti-inflammtory drug carprofen on the lumbar cerebrospinal fluid (CSF) concentration of noradrenaline (NA) and serotonin (5-HT) in non-stimulated (Part I) and surgically stimulated (Part II) sheep. METHODS: In a prospective controlled study the effects of a single intravenous (i. v.) bolus injection of 4 mg/kg carprofen (CARP; n = 14), 0.01 mg/kg fentanyl (FENT; n = 12) or 0.9 % saline solution (NaCl; n = 13) on lumbar CSF concentrations of NA and 5-HT were evaluated in non-stimulated sheep. In addition, CSF concentrations were evaluated in isoflurane-anaesthetised sheep at different time points T1 (30 min after i. v. treatment with 4 mg/kg carprofen [n = 8] or saline [n = 7], T2 (20 min of constant end-tidal isoflurane concentration of 2.4 %) and T3 (during stifle arthroscopy at 2.4 % end-tidal isoflurane). RESULTS: CSF concentrations of NA (NaCl: 170.23 +/- 16.86 pg/ml [x +/- SEM], CARP: 200.79 +/- 28.94 pg/ml, FENT: 209.58 +/- 27.67 pg/ml; p = 0.524) and 5-HT (NaCl: 2752.46 +/- 413.87 pg/ml, FENT: 2969.08 +/- 684.05 pg/ml, CARP: 3232.93 +/- 713.93 pg/ml; p = 0.978) were not significantly different between the three treatment groups of non-stimulated sheep. In the anaesthetised sheep, mean CSF-5-HT at T3 (NaCl: 6670.25 +/- 313.63 pg/ml; CARP: 4080.80 +/- 539.59 pg/ml) was significantly increased compared to T1 (NaCl: 2818.4 +/- 1104.54 pg/ml, p < 0.001; CARP: 2926.13 +/- 818.66 pg/ml, p = 0.022) and T2 (NaCl: 2593.67 +/- 618.89 pg/ml, p = 0.002; CARP: 2724.13 +/- 395.39 pg/ml, p = 0.012) in both treatment groups. Moreover, mean CSF-5-HT at T3 in the saline group was significantly higher (p = 0.006) compared to the CARP-group. Unlike changes in CSF-5-HT, no significant changes in mean CSF-NA were recorded neither within nor between the two treatment groups. CONCLUSION: During arthroscopy in isoflurane-anaesthetised sheep, surgical stimuli may significantly increase mean CSF-5-HT concentration. This effect can be attenuated by pre-treatment with 4 mg/kg carprofen intravenously. Therefore, the analgesic effects of carprofen may be at least in part mediated by central serotonergic mechanisms.
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A volume replacement should compensate a reduction in the intravascular volume and counteract a hypovolemia so that hemodynamics and vital functions can be maintained. For this therapy, a physiologically-based solution comprising both osmotically and colloid osmotically active components should be administered. A consensus is proposed for this purpose which takes into consideration the following aspects: The optimum colloid, the questionable use of albumin, the physiological electrolyte pattern encompassing sodium, potassium, chloride and phosphate and their contributions to osmolality, an eventual addition of glucose, the physiological acid-base status with bicarbonate or alternately with metabolisable anions, and the importance of a clear declaration of all ingredients. The consensus distinguishes between compulsory requirements derived from evidence-based medicine and physiological data and the potential expectations of an optimal volume replacement, including well-grounded wishes and aspirations for the future.
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Analgesia is one of the physician's genuine challenges. Pain makes the patient suffering and leads to unfavourable somatic effects as well, which may have negative outcome effects. Sufficient perioperative analgesia depends on well defined organizational conditions. General responsibility, indication, choice and dosage of drugs should be defined in advance to enable a prompt and sufficient reaction in normal cases. Systemic analgesia is simply to perform and the cornerstone of perioperative analgesia. Non-opioid analgesics are indicated in minor and limited pain. If necessary, opioids are added. Opioids are very powerful analgesics and-in principle-sufficient to meet all clinical challenges. Special syringe pumps allow a patient controlled analgesia (PCA) under fixed conditions. Regional anaesthesia via catheter is powerful as well and avoids systemic opioid side effects. In these cases as well, a continuous or patient controlled analgesia is possible.
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Skilful analgesia is self-explanatory and needs no justification. In contrast to this, preclinical general anaesthesia is of relative value and depends, in part, on the professional qualities of the emergency physician. Analgesic and anaesthestic drugs should be administered via a safe intravenous line. In contrast to rapid sequence induction of general anaesthesia, analgesic drugs should be titrated. The patient has to be monitored by the vigilance of the physician and adequate technical equipment. Metamizol is used for treatment of minor and medium pain, while morphine is indicated for treatment of major pain, especially in internal patients. Fentanyl is mainly used for total intravenous anaesthesia with controlled ventilation. (S)-ketamine is indicated for analgesia, analgosedation and anaesthesia in trauma patients, except isolated or dominating craniocerebral trauma, and in special internal cases. Midazolam is used for sedation or, in combination with (S)-ketamine or fentanyl, total intravenous anaesthesia. Etomidate is especially useful for induction of emergency patients with sufficient cardiovascular stability. Suxamethonium is the standard relaxant for endotracheal intubation during rapid sequence induction. If longer muscle relaxation is necessary, vecuronium should be used due to its simple storage and general lack of untoward effects. Butylscopolamin is used in colic pain, either alone or in combination with analgesic drugs. Haloperidol is indicated in acute psychotic syndromes as well as psychomotoric and alcohol-dependent excitation. On the whole, profound pharmacological and practical knowledge is necessary, although restricting oneself to just a few drugs increases the depth of one's personal experience.
OBJECTIVES: The study was undertaken to compare different anaesthetic techniques for scheduled or urgent caesarean section with respect to maternal circulatory parameters, maternal and fetal endocrine stress response, fetal vitality parameters and further clinical parameters such as recovery and analgesic demand. METHODS: After ethical approval,patients scheduled for general anaesthesia were randomly allocated to the esketamine group ( n=21; induction with 0.5 mg/kg BW esketamine and 1.5 mg/kg BW methohexitone, ventilation until cord cutting with FiO(2) 1.0) and the sevoflurane-group ( n=21; induction with 1.5-2.0 mg/kg BW methohexitone, ventilation until uterotomia with N(2)O/O(2) [FiO(2) 0,5] and endtidal sevoflurane concentrations about 1.0 vol%). After fetal development, all patients received 2.5 microg/kg BW fentanyl and sevoflurane (about 1.0 vol% endtidal) during ventilation with N(2)O/O(2) (FiO(2) 0.33). As a further control, a group with spinal anaesthesia ( n=22; 2.6-3.0 ml isobaric bupivacaine 0.5 %) was investigated. Maternal circulatory and endocrine plasmatic stress parameters were investigated at five time points and fetal parameters once after development.alpha< or =0.05 was considered significant. RESULTS: Biometric data were comparable in all groups. Systolic arterial pressure was higher in the esketamine group ( p=0.008), whereas the heart rate was lower during spinal anaesthesia ( p<0.001). Plasma noradrenaline decreased in all collectives ( p<0.001) and mean group levels of noradrenaline ( p=0.04) and adrenaline ( p<0.001) were lower during spinal anaesthesia. In all groups, antidiuretic hormone (ADH) remained within the normal range or was slightly increased. Adrenocorticotropic hormone (ACTH) initially increased in all groups and decreased in later time course ( p<0.001). Cortisol increased in all groups ( p<0.001) but group levels were lower during spinal anaesthesia ( p<0.001). In the groups with general anaesthesia, no significant differences in recovery times were obvious, and neither recall nor dream reactions were observed. Postoperative hypoxic incidents (psaO(2) <90%) were comparable between the groups. After spinal anaesthesia, first analgesic demand was later than in the controls ( p=0.001), and the total amount of piritramide was lower ( p=0.02). Nausea and vomiting were more frequent during spinal anaesthesia ( p=0.03). All patients were content with their regimen. Apgar scores, pH-values and adrenaline, noradrenaline and cortisol in plasma were comparable in all groups of children (69 children, 5 gemini). The fetal concentration of esketamine (251 ng/ml) was lower than the corresponding maternal values (493 ng/ml). CONCLUSIONS: When compared with methohexitone, sevoflurane and N(2)O for caesarean section, initial total intravenous anaesthesia with esketamine and methohexitone mediated specific antinociception without negative maternal or fetal effects and not taking invasion kinetics or elimination between uterotomia and cord cutting into consideration. Avoidance of N(2)O allows optimal oxygenation of the fetomaternal unit. Stress protection and hemodynamic responses were well balanced, and intraoperative recall or negative dream reactions were lacking. Superior postoperative pain protection was advantageous after spinal anaesthesia, but in contrast, nausea and vomiting were more frequent in this group.
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UNLABELLED: Anaesthesiology has given essential impulses to emergency medicine during the last decades. Therefore emergency medicine has become the "third column" of this speciality. As a "generalist with special skills" the anaesthetist fulfils the requirements of an emergency physician to a high degree. The scientific field of emergency medicine is subjected to a considerable amount of changes and requires qualified training and further education; in this context the guidelines for cardiopulmonary resuscitation are of outstanding importance. In the governmental-controlled emergency care system, the emergency physician and the chief emergency physician are responsible for both the individual treatment of patients and the management of major incidents and catastrophes. Moreover, the interhospital transfer is gaining increasing importance. Even though a high quality standard of the German emergency medicine system can be stated, there are still clear deficits such as the lack of integrated dispatch centers and the lack of the position of a medical physician as emergency care leader in each area. A leading structure for the management of major incidents and disasters is established to a great extent, nevertheless personal and material deficits exist in this field especially considering a rising terroristic threat. In the in-hospital emergency medicine anaesthetists are of essential importance for the interdisciplinary teamwork in the resuscitation room, medical treatment of in-hospital emergencies on the wards and outside on the hospital ground, and for internal as well as external major incidents and disasters. This is not always recognized in public opinion, so that the interdisciplinary integration must be secured and reinforced. IN CONCLUSION: A major goal is to preserve emergency medicine as the third column of anaesthesiology and to protect achieved standards, to reinforce research in preclinical and clinical emergency medicine, and to take up new challenges in the future.
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