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Biomedical subjects

H Achenbach

Publications and source records attributed to H Achenbach.

At least 37 records · Page 2Linked to original sources
PubMed1992

New Lignan Glucosides from Stemmadenia minima*.

Reinvestigation of the polar fractions from the stem bark of STEMMADENIA MINIMA A. Gentry (Apocynaceae) afforded two known and four new lignan glucosides. Their structures were deduced by spectroscopic and chemical methods.

Journal Article↗
PubMed1989

[Verapamil in primary hyperparathyroidism].

In a female patient with primary hyperparathyroidism and disturbances of cardiovascular function clinical, biochemical and electrocardiographic as well as bone scintigraphic parameters were analyzed before and during therapy with verapamil (Falicard) for 7 month. Verapamil therapy resulted in decrease of the frequency of the supraventricular tachycardia, and, in higher doses (4 X 120 mg), also reduction of blood pressure, however, with dose limiting bradycardia and prolongation of PQ-time. Both the normalization of serum phosphate level, diminution of hypercalcemia of the ionized calcium and the decrease of hypercalciuria and increase of scintigraphic index as an expression of the decrease of high activity of bone metabolism suggest alterations of the calcium homeostasis. Under oral calcium load the constantly increased PTH values markedly could be suppressed indicating an alteration of intracellular parathyroid calcium set point. Discussion is performed with respect to possible protective metabolic and cardiovascular effects of calcium antagonists in this endocrine functional disorder.

Adult↗
PubMed1989

[Aluminum-induced osteopathy--pathogenetic mechanisms].

The causal connection of aluminium accumulation in the organism and of toxic aluminium effects on the bone metabolism is at present regarded as extensively ascertained. On the other hand, there is no final consent about the fact which exact pathomechanisms are the basis of the aluminium effects. Apart from the direct interaction of aluminium with osseous transformation processes influences of the aluminium load of the body on significant, modulating the bone turnover extraosseous factors could be proved. Discussions about the complex pathogenetic principles of aluminium-induced bone changes concentrate themselves upon inhibitory effects of aluminium in the process of mineralisation, upon immediate toxicity of aluminium on the bone cells, potential interactions between aluminium and changed NSD-function as well as the influence of the aluminium accumulation on the vitamin-D-balance.

Aluminum↗
PubMed1989

[Secondary L-carnitine deficiency in chronic hemodialysis patients].

L-carnitine is an essential substance for the decomposition of long-chain fatty acids and thus for the obtaining of energy in the mitochondria. The L-carnitine fractions in the serum were analysed in 10 patients undergoing haemodialysis before and after the dialysis treatment. 4 patients received a substitution of L-carnitine by oral application of 3.0 and 1.0 g, respectively, after every dialysis or as addition to the dialysate (ca. 62 mumol/l) for in each case 4 weeks. In patients undergoing dialysis the serum carnitine fractions were in many cases already clearly diminished before the dialysis. During the treatment the total L-carnitine levels decreased by ca. 50%, the free L-carnitine values by ca. 70%. Particularly distinct carnitine depletions were found in patients with catabolic metabolic condition, incompatibility of dialysis and post-dialysis syndrome. All forms of application and dosages chosen led to a good correction of the serum carnitine concentrations. 2 patients with oral L-carnitine substitution of 3.0 g and resulting from this serum carnitine levels highly significantly lying above the normal region mentioned ameliorations of the subjective lipid parameters cholesterol, HDL-cholesterol and triglycerides could not be changed in the short period of observation by substitution of L-carnitine.

Adult↗
PubMed1989

Plasma exchange for removal of anti-A and anti-B group antibodies in AB0 major-incompatible bone marrow transplantation.

Between 1980-1986 seven patients underwent AB0-major incompatible bone marrow transplantation. Incompatible anti-A and anti-B antibodies could be decreased by the plasma exchange from titers 8-256 down to 0-8. Our practice combined with additional depletion of erythrocytes from marrow allowed to transplant all patients successfully, however, one patient demonstrated an acute haemolytic reaction during infusion of marrow. Plasma exchange was fairly well tolerated, however, 4 patients developed slight urticarial reactions. Both thrombocytopenic patients overcompensated the platelet loss caused by the exchange.

ABO Blood-Group System↗
PubMed1988

[Arteriovenous fistula in the tabatière region--primary shunt in chronic hemodialysis].

The number of patients with end-stage renal disease treated by chronic hemodialysis is permanently increased. An assumption of a long-term and successful treatment is the durable functioning vascular access. The method of choice worldwide is the typical Cimino fistula on the distal forearm, but a more peripheral arterio-venous fistula is possible. A fistula in the Tabatière region has proved to be excellent in our experience with 51 patients operated between January 1985 and March 1987. The surgical technique, results, and advantages of this vascular access operation are described.

Adult↗
PubMed1986

[Effectiveness of plasma exchange therapy in patients with rheumatoid arthritis and systemic manifestations].

For the advantage of the therapeutic plasma exchange in the active rheumatoid arthritis there exist at present contradictory opinions. Three patients with rheumatoid arthritis and systemic manifestation as well as high activity of the disease, in whom the conventional therapy with antirheumatic drugs showed only little effectiveness and which was stopped due to severe side effects, respectively, underwent 6 plasma exchange treatments within 14 days. The subjective condition as well as standardized clinical and laboratory-chemical activity parameters quickly ameliorated. A positive therapeutic effect was to be proved still after 6 to 12 months. In 2 patients a proposed synovectomy could be renounced. The reasonable indication for the plasma exchange will be given when there is an acute immunological reaction which can be shortened by a rapid reduction of pathogenic protein fractions before irreversible morphological injuries occur.

Acrodynia↗
PubMed1986

High-grade epithelioid angiosarcoma of the scalp. An immunohistochemical and ultrastructural study.

The ultrastructural and immunohistochemical characteristics of a high-grade epithelioid angiosarcoma of the scalp are reported. By light microscopy, the neoplasm simulated a poorly differentiated carcinoma, either primary or metastatic from some occult site. Immunohistochemical study, using a specific antibody against factor VIII-related antigen, was positive when direct immunofluorescence was applied to frozen specimens of the neoplasm. Application of immunoperoxidase (avidin-biotin complex method) on paraffin-embedded tissue using the same antibody was negative. Ultrastructually, the neoplasm had a prominent cytoskeleton of intermediate filaments, numerous pinocytotic vesicles, small intercellular lumina with microvilli on their surfaces, and characteristic intracytoplasmic vacuoles. A brief discussion of the differential diagnostic features is made.

Aged↗
PubMed1986

[Cellular immunity in dialysis patients using the lymphocyte transformation test (LTT) in comparison to conservatively treated patients with chronic terminal renal failure].

By means of the lymphocyte transformation test (LTT), using the mitogens phytohemagglutinin (PHA), concanavalin A (ConA), lipopolysaccharide (LPS) E. coli and the antigens tuberculin (PPD) and O-streptolysin, a contribution should be made for the judgment of the functional capacity of the immune system--in particular of the cellular immunity--in uraemia patients with and without dialysis therapy. In 33 patients with different duration of the dialysis (0.5 to 130 months) and 15 retention patients who were not yet treated by means of dialysis the LTT was controlled with stimulant agents mentioned above. In these cases was shown that dialysis patients managed metabolically regularly did not show a significant restriction of the cellular immunity in the LTT (PHA-stimulation over 0.55 transformed cells, con-A-stimulation over 0.37 transformed cells). The not dialysed patients with chronic uraemia showed a distinct diminution of the unspecific T-cell transformation by PHA and ConA, whereas the antigen-induced stimulation (PPD, O-streptolysin) was not disturbed in this case as well. In the two cases the B-cell transformation (on LPS) was not significantly disturbed. There was a good concordance with the clinical findings: scarcely general infects, no shunt infections, relatively many organ losses by rejection after transplantation in the dialysis patients. The not yet dialysed retention patients revealed clinically a higher inclination to an infect. There were no own experiences about the course after transplantation without preceding dialysis. It is discussed in how far also immunological investigations may play a role in the establishment of the optimum management of the dialysis, the moment of the beginning with the dialysis and for the "more individual preparation of the transplantation".

Antigens↗
PubMed1985

[Results of immunosuppressive therapy of chronic glomerulonephritis in 400 patients].

For the judgment of the success of the immunosuppressive therapy of chronic glomerulonephritis 400 patients (242 males and 158 females) at an average age of 31.2 years were examined after an average duration of treatment of 31.9 months. Apart from the renal function (serum creatinine), the histological and immunohistological form of the glomerulonephritis for the valuation further clinico-paraclinical data were taken into consideration: proteinuria, nephrotic syndrome, arterial hypertension and the combination of nephrotic syndrome and arterial hypertension. At the beginning of the treatment 293 of 400 patients (73.2%) had a normal renal function, 107 of 400 patients (26.8%) were initially renal-insufficient. 16 of 400 patients (4.0%) had additionally a pyelonephritis and 12 of 400 patients (3.0%) had a lupus nephritis. 27 of 400 patients (6.9%) developed a terminal renal insufficiency after an average duration of observation of 40.5 months. Complications caused by therapy were registered in 104 of 400 patients (26.0%). Recommendations for the present therapy of chronic glomerulonephritis are formulated.

Adolescent↗