[Numerical computer simulation of the distribution of thoracic potentials in the human].
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Biomedical subjects
Publications and source records attributed to H Brauer.
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The effectiveness of day hospital care of geriatric psychiatric patients was evaluated in a pilot study. The main aspect was the training of social competence, i.e. a training leading to growing personal independence of the demands of every day life, such as hygiene , fitness considering the household, etc. During day hospital treatment a significant improvement regarding social competence was attained. A one year follow-up showed a moderate decline in the patients' performances of the earlier trained skills.
Chronic psychiatric patients (N = 42) predominantly diagnosed as schizophrenics, who had been hospitalized for the mean of 9 years were treated in a double-blind study with a neurotropic drug (tamitinol dihydrochloride coated tablets of 300 mg t.i.d.) and placebo. Test drugs were administered concomitantly to the existing drug therapy during two treatment periods of 6 weeks each with an interval of two months free of test medication. In the second treatment period patients moved to a new building. It was expected that neurotropic drug effects can be made clearer after the transfer requiring patient's reorientation in a new environment than before the transfer. Assessment of efficacy was made using observer ratings (Psychic and Somatic Findings of the A.M.P. System, WING Behaviour Rating Scale) and patient's self ratings (Adjective Check List. List of Somatic Symptoms) and clinical laboratory parameters. Results show that neurotropic co-medication reduced the "neurological syndrome" and the "psychoorganic syndrome" (A.M.P. System). An amelioration of the "neurological syndrome" was observed at the end of the first and at the end of the second medication phase (p less than or equal to 0.10) whilst the improvement of the "psychoorganic syndrome" was particularly evident as expected after the transfer to the new building (p less than or equal to 0.001) Patients receiving placebo described themselves as more active than patients receiving the test drug. (Adjective Check List: p less than or equal to 0.10). No subjective or objective side effects (List of somatic symptoms and laboratory parameters) were evident due to the test medication which was tolerated by all patients.
For 341 patients treated with psychotropics over different periods of time and with different dosages laboratory examinations were carried out in order to discover as far as possible toxic damage of the parenchyma of liver, kidneys, and blood-formation systems. Statistically secured differences of some liver functions and of the serum creatinine between treated and untreated patients were seen for which, however, no sufficient indication of direct toxic damage was found. The deviations were interpreted as allergic and caused by enzyme induction.
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We examined the influence of local tissue conductivity changes in the vicinity of a dipolar source on the neuromagnetic field and the electric scalp potential using a high resolution finite element method model of the human head. We found that the topology of both the electric scalp potential and the neuromagnetic field (and consequently dipole localization) is influenced significantly by conductivity changes only in voxels adjacent to the source. Conductivity changes in these voxels yield a greater change in the amplitude of the magnetic field (and consequently in the dipole strength) than in the amplitude of the electric potential.