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Biomedical subjects

H Brunner

Publications and source records attributed to H Brunner.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Significance of Ureaplasma urealyticum in the sperm of fertility patients].

U. urealyticum was found in the semen of 12.9% of the patients, who attended a fertility clinic. Ureaplasma counts of more than 1,000 CFU/ml were demonstrated in 8.6% of cases. Non-specific genital infection caused by U. urealyticum was rarely diagnosed, and there was no correlation of the ureaplasma counts and the spermatological findings in cases without inflammation.

Humans↗
PubMed1979

Electron microscopic studies on the attachment of Mycoplasma pneumoniae to guinea pig erythrocytes.

A mechanism of pathogenicity of Mycoplasma pneumoniae is its ability to attach to the surface of mammalian cells. It has previously been demonstrated by others that M. pneumoniae adheres with a specialized terminal structure, the "tip," to ciliated epithelial cells of the respiratory tract. In this report we show by electron microscopy that M. pneumoniae adsorbs with membrane sites other than the tip to guinea pig erythrocytes.

Animals↗
PubMed1979

Complement components (C1, C2, C3, C4) in bronchial secretions after intranasal infection of guinea pigs with Mycoplasma pneumoniae: dissociation of unspecific and specific defense mechanisms.

Shortly after intranasal infection of guinea pigs with Mycoplasma pneumoniae, the titers of the complement components increased significantly in bronchial secretions by the folllowing amounts, compared with the titer of a control group: C1, about 2-fold; C2, 1.6-fold; C3, 17-fold; and C4, 942-fold. Histopathological signs of inflammation were not apparent at this time. At 2 weeks after infection, when the titers of complement components in the bronchial secretions were at the level of control values or lower, the serum antibody titer increased, and it reached the highest level at 6 weeks after infection. Therefore, one can distinguish two phases of reaction of the macroorganism to intranasal inoculation. The increase in complement components shortly after infection may represent an earlyunspecific defense mechanism of the host before the specific immune response becomes effective, since the complement system can be activated by M. pneumoniae via the classical as well as the alternative pathway in the absence of antibodies.

Administration, Intranasal↗
PubMed1979

Serological cross-reactions between Acinetobacter calcoaceticus and chlamydiae.

A cross-reaction between Acinetobacter calcoaceticus and chlamydiae is described. A water-soluble, heat stable, non-dialyzable antigen was extracted from Acinetobacter species by boiling. This antigen fixed complement in the presence of homologous hyperimmune sera from rabbits or guinea pigs and in the presence of heterologous human or hyperimmunized animal sera containing chlamydial antibodies. Hyperimmune antisera to the extracted antigen, or to suspensions of live acinetobacters, also reacted in complement fixation with a group-specific antigen.

Acinetobacter↗
PubMed1979

[Complement-fixing antibodies to chlamydia in the population (author's transl)].

2,213 sera of normal persons and of men with nongonococcal urethritis were tested by CF. 4.5% of the males, 9.2% of the females, and 10.8% of the urethritis-patients had titers of 1 : greater than or equal to 16 when tested against a group-specific chlamydial antigen. The usefullness of the CFT for seroepidemiological studies was confirmed.

Adolescent↗
PubMed1979

[The mycoplasma-pneumonia. A model for the study of the pathogenesis of infectious diseases (author's transl)].

The known mechanisms of pathogenicity of Mycoplasma pneumoniae are discussed. In addition, evidence is provided for the participation of the immune system in the pathogenesis of M. pneumoniae disease. In a working hypothesis the stimulation of a protective and/or a reactive immune response is postulated, depending on the predisposition of the host, the infecting dose, the frequency of contact and the virulence of the organisms. Because well studied animal models are available, the Mycoplasma-Pneumonia is well suited to investigate the pathogenesis of infections caused by bacteria and the defense of the host.

Animals↗
PubMed1978

[Somatostatin in the treatment of acute haemorrhage from a duodenal ulcer (author's transl)].

A massive haemorrhage from a duodenal ulcer verified on endoscopy in a 21 year-old patient was stopped by a 62--hour infusion of somatostatin at a dosage of 250 microgram/hour. Suppression of gastric secretion is probably more important than the reduction in splanchnic blood flow with regard to the mechanism of action of this drug. No side effects were observed.

Adolescent↗
PubMed1978

Determination of IgG, IgM, and IgA antibodies to Mycoplasma pneumoniae by an indirect staphylococcal radioimmunoassy.

An indirect staphylococcal radioimmunoassay (SRIA) has been developed for determination of M. pneumoniae antibodies. This test allows the detection of antibodies in various immunoglobulin (Ig) classes similar to the previously described radioimmunoprecipitation test (RIP). SRIA has two advantages over RIP: first, it uses 100-fold less anti-Ig reagents than RIP; second, bound can be separated from unbound antigen more easily by the relatively heavy staphylococci. SRIA antibodies, belonging to the IgA class of Ig, could be detected in nasal secretions of volunteers infected intranasally with ts H43 of M. pneumoniae. In sera of patients with M. pneumoniae pneumonia antibodies to the IgG or the IgM class of Igs could be determined separately. This is especially important for an early diagnosis of M. pneumoniae disease.

Antibodies, Bacterial↗
PubMed1978

[The importance of ureaplasma urealyticum in non-specific prostato-urethritis (author's transl)].

312 patients with non-specific prostato-urethritis were investigated with a standardised procedure using the four glass test. In 42.3% of patients mycoplasma was isolated which in almost all cases was Ureaplasma urealyticum. Clinically patients were symptom-free after eradication of mycoplasma in cases where previously urea-plasma counts of more than 10,000 CFU/ml prostatic secretion and of more than 1000 CFU/ml urine had been demonstrated. In cases where there were smaller counts of Ureaplasma urealyticum and where Mycoplasma hominis had been demonstrated tetracycline therapy did not lead to cure in any case.

Adult↗
PubMed1978

Haemodynamic effects of the beta-receptor blocking agents metoprolol and propranolol in the anesthetized dog.

The haemodynamic effects produced by intravenous infusions of the beta-blocking agents metoprolol and propranolol in doses of 0.3 and 1 mg/kg/10 min were compared in anaesthetized dogs. When administered in a dose of 0.3 mg/kg/10 min, metoprolol caused a longer-lasting increase in pulmonary-arterial pressure and total pulmonary resistance, a greater increase in pulmonary capillary pressure and a more marked decrease in O2 partial pressure in the arterial blood than propranolol. These differences are probably due to differences in the pharmacokinetics of the two drugs. The effects of the two beta-blockers in a dose of 1 mg/kg/10 min were similar. At neither of the dose-levels tested were the changes induced by the compounds in the various parameters studied clearly dose-related.

Animals↗
PubMed1978

Preparative isolation of middle molecular weight fractions from the hemofiltrate of patients with chronic uremia.

Fractions in the molecular weight range of the so-called middle molecules (500--3000 daltons) were isolated on a preparative scale from hemofiltrate of patients. Hemofiltration was performed with an RP-6 dialyzer using a predilution technique. The hemofiltrate was concentrated and desalinated by reverse osmosis with membranes with a normal cut-off of 500 daltons. The retentate was freeze-dried, redissolved in volatile buffer and fractionated on Sephadex G-15 macrocolumns. The middle molecule molecular weight range in the elution profiles (detected at 206 and 280 nm simultaneously) was marked with peptides. Isolated fractions in the middle molecule molecular weight range showed strong inhibitory activity upon 3H-thymidine incorporation into rat bone-marrow cells in vitro. The described combination of hemofiltration, reverse osmosis and gel chromatography is suggested as a useful approach to the isolation of these ninhydrin-positive substances which, according to their proved heterogeneity, are to be subfractionated by further procedures.

Chromatography, Gel↗