Biomedical subjects

H D Gnad

Publications and source records attributed to H D Gnad.

At least 55 records · Page 3Linked to original sources

PubMed1983

Amikacin levels in human aqueous humor.

Amikacin is one of the newer aminoglycoside antibiotics. The penetration of amikacin into the human primary aqueous humor after intramuscular application was investigated. Comparing our results with reports concerning the blood aqueous permeability of gentamicin and tobramycin we could not find any significantly better penetration of amikacin into the human aqueous humor after i.m. injection. The advantage of amikacin lies in its effectiveness against bacteria resistant to other aminoglycosides.

Aged↗

PubMed1982

Collagen types in keratoconus.

Collagen types in normal human and keratoconus corneas were separated by salt fractionation and thermal gelation in the pepsin-soluble fraction of the lyophilized tissues. Peptic digestion indicated no significant differences between normal and keratoconus corneas. Further collagen characterization was performed using SDS-PAGE. Collagen concentration were determined via hydroxyproline. Soluble collagens from normal human cornea represent 85% collagen type I, maximally 10% collagen type III and 5% collagen type V. Soluble collagens of keratoconus corneas consist of 90% type I collagen and maximally 5% type II and type V collagen.

Chemical Fractionation↗

PubMed1982

[Photocoagulation supplementing pitting surgical procedures in amotio retinae].

In cases of incomplete closure of the retinal defect following retinal detachment surgery photocoagulation may render a second surgical intervention unnecessary. The premise for its applicability is a retinal defect resting on an adequate scleral buckle. Indications are incompletely sealed breaks causing a recurrent or residual detachment of the retina. Massive vitreous traction should be absent. The results of 32 cases (out of a total of 692 retinal detachment operations performed within the past five years) in which postoperative photocoagulation was applied are very encouraging: in 28 cases it was possible to complete the closure of the retinal defect, resulting in healing of a residual detachment or redetachment of the retina, respectively. In the course of daily applied photocoagulation (over a period of two to six days) starting from a zone of extremely flat detachment of the defect's border one may gradually achieve adhesion even of higher detached portions of the defect area.

Humans↗

PubMed1982

[Coagulation technic in diabetic maculopathy].

One hundred thirty-six eyes with diabetic maculopathy, which had been operated on by photocoagulation between 1976 and 1980, were followed up with regard to the morphology of the retinal changes and compared with 246 untreated eyes. Of the treated eyes, 77% showed no further progression of the microangiopathy, whereas in 80% of the untreated eyes the development of a diabetic maculopathy was observed.

Adult↗

PubMed1982

[Postoperative intraocular pressure following iris-clip lens implantation].

Within the past three years intraocular Binkhorst lenses have been implanted in 152 consecutive cases. In 36% of the intracapsularly operated cases (123 eyes) and 45% of the extracapsularly (29 eyes), intraocular pressure increased to 40 mm Hg for three to four days postoperatively. Pseudophakic-pupillary block glaucoma was not observed in any of the cases. Fourteen days postoperatively no case required glaucoma treatment. As in normal aphakic eyes, intraocular pressure dropped to subnormal values 8 weeks postoperatively in 6% of the cases.

Cataract Extraction↗

PubMed1982

[Immunopathogenesis of primary open-angle glaucoma].

By means of direct immunofluorescence technique the trabecular meshwork of patients with primary open-angle glaucoma, obtained at the time of filtering surgery, and the trabecular meshwork of controls were investigated for the presence of immunoglobulins and the complement component C3. In neither group were such deposits found; this indicates a lack of immunogenic mechanisms in primary open-angle glaucoma.

Fluorescent Antibody Technique↗

PubMed1981

[Serum immunofluorescence examination in loa ophthalmia (author's transl)].

Loaiasis is a chronic parasitic disease caused by the filaria Loa loa.As soon as the worm reaches the subconjunctival space local irration ensues. This so-called Loa ophthalmia necessitates immediate surgical intervention which can be performed under topical anesthesia, using the slit lamp. The indirect immunofluorescence technique represents a valuable diagnostic test,since it is usually difficult to demonstrate the microfilaria in the peripheral blood.

Adult↗

PubMed1981

[Nervus of ota (author's transl)].

A 27-year-old woman presented with a distinct gray-blue coloration of the left eye and the periorbital region. The right periorbital region also displayed minimal pigmentation. It was established that eye drops containing mercury had been administered for some years. Initially hydargyrosis was considered as an etiologic factor. Finally we arrived at the diagnosis of nevus of Ota on conjunction with a blue nevus on the forehead. The simultaneous occurrence of a nevus of Ota and the blue nevus suggest a common basic developmental disturbance. The nevus of Ota represents a benign dermal hyperpigmentation syndrome and has to be differentiated from melanosis bulbi.

Adult↗

PubMed1981

[Factors provoking the development of rubeosis iridis after vitrectomy in diabetics (author's transl)].

A retrospective study on 184 eyes of 167 diabetics which had been submitted to a vitrectomy because of various affections of the vitreous body and retina shows, that aphakic eyes, cases suffering from repeated bleeding into the vitreous cavity, and eyes with advanced stages of diabetic retinopathy are mostly preposed to the development of rubeosis iridis. Coincidence of two of these factors was found in more than two thirds of the eyes with post-operative rubeosis iridis. The stage of the diabetic retinopathy was preoperatively determined by means of ultrasonography.

Diabetic Retinopathy↗

PubMed1981

[Late results of pars plana vitrectomy in diabetics (author's transl)].

Report on 82 consecutive cases in which pars plana vitrectomy was performed because of intravitreal hemorrhage. Postoperative follow-up ranged from 3 to 4 1/2 years. Although an incipient improvement of the visual acuity was achieved in 54%, recurrent hemorrhages as well as progression of the proliferative diabetic retinopathy lead to visual deterioration of blindness in 64% of the eyes.

Blindness↗

PubMed1980

[Subvitreal hemorrhage in a case of juvenile hypertension with aneurysm of the internal carotid artery (author's transl)].

The etiology of subvitreal hemorrhage in the course of subarachnoidal hemorrhage is briefly considered. The coincidence of juvenile hypertony and subarachnoidal hemorrhage resulting from intracranial aneurysms is then discussed. The necessity of timely vitrectomy is pointed out, with reference to a case of the author's in which intravitreal hemorrhage showed no tendency to resorption during a follow-up period of six weeks, and in which after a pars plana vitrectomy an organizing preretinal hemorrhage was eliminated.

Adult↗

PubMed1980

[Results of pars plana vitrectomy in diabetics].

Report on 96 cases in which pars plana vitrectomy was performed because of intravitreal hemorrhage. In 25 patients vitrectomy had to be performed bilaterally. Postoperative follow-up ranged from 3 months to 2 1/2 years. An improvement of visual acuity lasting at least 3 months was achieved in 58% of the cases. In 31% central vision remained unchanged, and in 11% cases the postoperative vision was decreased. Secondary hemorrhage necessitated a repetition of the intervention in 16 eyes.

Adult↗

PubMed1980

[Intravitreal injection of SF6 gas in vitreoretinal surgery (author's transl)].

Within the past 3 years intravitreal injection of SF6 gas was performed in 31 vitreoretinal surgical procedures. In 29 cases an additional vitrectomy was performed, and in 10 cases with massive periretinal proliferation (MPP) epiretinal membranes were stripped. The rate of success following intravitreal injection of SF6 gas as an adjunct to buckling procedures in severe cases of rhegmatogenous retinal detachment was 83%, as an additional measure in cases with giant tears extending over 180-225 degrees, 75%, in cases of tractional detachment due to preretinal and transvitreal strands, 60%, and in cases with MPP, 30%.

Fluorides↗

PubMed1980

[Early results after intraocular lens implantation (author's transl)].

Within the past 12 months, 64 intraocular lenses were implanted. Only eyes close to emmetropia and not exhibiting any pathological condition were considered for this type of surgery. The average age of our patients was 76 years. Preoperative medication and surgical procedure are described. Serious postoperative complications have not been observed so far. Striate keratopathy (in 22% of the cases), as well as secondary glaucoma (in 11% of the cases) were restricted to the initial 4-5 postoperative days. In 73% of the cases the postoperative visual acuity was 6/8-6/6. Maculopathy and opacification of the posterior lens capsule left behind were responsible for reduced visual acuity in the remaining cases.

Age Factors↗

PubMed1980

[Ocular involvement in polymyalgia rheumatica (author's transl)].

Polymyalgia rheumatica is a disease of the elderly, more common in women. Pain and stiffness localized in the proximal extremities respond well to low-dose corticosteroids. In roughly half of the cases, giant cell arteritis can be detected in apparently normal temporal arteries. There is no danger of ocular involvement in "pure" polymyalgia rheumatica, even with a positive biopsy. When cranial symptoms, such as headache or tenderness of the temporal arteries, appear, there is a great danger of ocular involvement, and high-dose corticosteroid treatment is advisable.

Adrenal Cortex Hormones↗

PubMed1980

Athalamia as a late complication after keratoplasty on aphakic eyes.

In 3 cases of keratoplasty in aphakic eyes 4--8 months after surgery a gradual flattening of the anterior chamber was observed. During the initial postoperative months there was no suggestion of any impending complication. No synechiae at the anterior chamber angle were present, the anterior vitreous face had remained intact without being in contact with the posterior corneal surface, and the intraocular pressure remained within normal limits. Separation of anterior synechiae as well as vitrectomy via pars plana resulted merely in a temporary amelioration of this condition. Within a few days the anterior chamber was abolished again. The corneal buttons displayed epithelial oedema; the deeper layers, however, remained clear. Development of secondary glaucoma was kept under control either by appropriate medication or by cyclocryotherapy. The phenomenon reported here developed only in cases in which the anterior vitreous face had remained intact. It seems possible that this type of late complication may be avoided by prophylactic vitrectomy.

Aged↗

PubMed1980

[Immunosuppressive therapy following penetrating keratoplasty (author's transl)].

In 6 cases with poor prognosis who had undergone perforating keratoplasty, the local steroid therapy was combined, for an average duration of 15 months, with a systemic treatment of cyclophosphamide and procarbazine. During a postoperative following up duration between 19 and 32 months five grafts remained clear, however, in 1 case this therapy could not stop an allograft reaction.

Adrenal Cortex Hormones↗

PubMed1980

[Vitrectomy via pars plana. A histological study and an analysis of clinical results (author's transl)].

The histological examination of the vitreous body after partial vitrectomy in the rabbit eye shows a rarefication and coarsening of the vitreous fibres after refilling the vitreous cavity either with sodium hyaluronate, regular Ringer solution or with Ringer-lactate solution containing dextrose and sodiumbicarbonate. An analysis of postoperative results of 139 eyes yields the following conclusions: 1. Removal of clear lenses is not justified since following vitrectomy the vitreous body in aphakes is not significantly clearer than in phakic eyes. 2. Moderate lens opacities do not constitute an indication for cataract surgery, they have been found to progress following vitrectomy only in 5% of the cases. 2. Important factors in the development of postoperative keratopathy are: Presence or absence of the corneal epithelium, type of contact lens used, age of the patient, stage of a diabetic retinopathy, duration of the surgical procedure, and the combined removal of lens and vitreous body via pars plana. 4. Rubeosis iridis indicates a terminal stage of the diabetic retinopathy and cannot be considered a complication of vitrectomy. 5. Postoperative haemorrhage occur at almost equal rate either with or without the intraocular application of daithermy, however, diathermy-coagulation has been applied only in advanced stages of proliferative diabetic retinopathy. 6. In the course of lavage of the vitreous cavity in cases of recurrent haemorrhages a progression of diabetic retinopathy was usually observed. Vitreous lavage within short periods of time, preferentially with 6 to 8 weeks following the initial procedure is therefore recommended in cases of recurrent haemorrhages.

Animals↗