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Biomedical subjects

H Dörfler

Publications and source records attributed to H Dörfler.

At least 19 recordsLinked to original sources
PubMed2003

[Hypoglycemic and vision impaired. When is a diabetic patient unfit to drive?].

Every physician providing care to diabetics will at some time be asked whether driving is allowed. The answer is often determined by the type of sequela that may develop, in particular diabetic retinopathy. Among the metabolic conditions, hypoglycemia is important. But the fitness of a diabetic to drive may be impaired more by such associated conditions as CHD or hypertension than by the diabetes as possible to drive, near-normal glucose levels and intensive counseling are necessary, to ensure not only that the patient can carry out the required control measures, and self-medicate, but also is able to recognize threatening hypoglycemia in good time. Good documentation of the physician's surveillance is the basis for the determination of fitness to drive by an independent expert.

Automobile Driving↗
PubMed1993

Lipoatrophic diabetes.

Explore the source record for details and available documents.

Diabetes Mellitus, Lipoatrophic↗
PubMed1991

[The morphology and clinical picture of epithelioid hemangioendothelioma of the lung].

A 36-year-old woman presented with multiple shadows, up to 1 cm in diameter, in both lungs revealed by routine chest radiography. Right thoracotomy showed numerous firm nodules in the middle and lower lobes. Histological examination of the wedge biopsy disclosed an epithelioid haemangioendothelioma of the lung (positive immunohistochemical reaction for factor VIII-associated antigen). Eight years later the patient remains symptom-free without treatment and the radiological picture is almost unaltered. Another woman, 22 years old, had a skin nodule near the right external malleolus. It was removed and found to be a semi-malignant haemangioendothelioma. Five years later a chest radiograph showed finely nodular shadowing in both lungs which roused suspicion of sarcoidosis. She had steroid therapy for one year, but the radiological findings remained unchanged. After a further 10 years a round lesion, some 3 cm in diameter with partial calcification, was found in the right lower lobe. Histological examination revealed an epithelioid haemangioendothelioma with a positive immunohistochemical reaction for factor VIII-associated antigen. She subsequently complained of severe pain in the left shoulder (with histologically demonstrated bone involvement by the neoplasm) together with rapidly increasing dyspnoea. Seventeen years after the original diagnosis she died of rapidly progressive diffuse lymphangiomatosis carcinomatosa. Post mortem secondary deposits were found in the liver as well.

Adult↗
PubMed1990

[Bone pain in adults as the first symptom of late congenital syphilis].

A 20-year-old woman developed multifocal bone pain. Diagnostic radiology revealed thickened periosteum, and syphilis serology was positive (T. pallidum haemagglutination test 1:5120). She also had discrete signs of congenital syphilis, with retinitis pigmentosa and Hutchinson's incisors. Skeletal scintigraphy demonstrated increased uptake even in radiologically unremarkable bones. The bone pain decreased after four-week administration of 1 M units of penicillin G daily. Scintigraphy one year later showed regression of the increased uptake, skeletal radiology did not reveal significant changes. This case shows that late manifestations of congenital syphilis still occur today. The stigmata of such an infection can be minute and easily missed. Skeletal scintigraphy is better for demonstrating active bone involvement than conventional radiology.

Adult↗
PubMed1990

Sclerosing epitheloid angiosarcoma of bone and lung--intravascular sclerosing bronchioloalveolar tumor.

A 39-year-old woman was admitted to hospital with severe pain in the left shoulder due to an endothelial bone tumor. The tumor showed the same histologic signs as an intravascular sclerosing bronchioloalveolar tumor of the lung (IVBAT) which had been enucleated 2 years previously. This combination is uncommon. It is discussed whether the IVBAT is a malignant tumor with metastases or a benign tumor with coincidental tumors in other organs of the same endothelial vascular origin. We consider this to be an epitheloid angiosarcoma of the lung with, in our case, bone metastases; this is in agreement with some most recent reports on the disease.

Adult↗
PubMed1990

[Angiomyolipoma of the kidney--value of imaging procedures].

The angiomyolipoma of the kidney is composed by blood vessels, smooth muscle tissue, and fat. It is important to differentiate this benign tumor from a malignant one. Two cases demonstrate the diagnostic value of the different imaging procedures. In 'typical' cases computed tomography shows the density of fat; histological examination is not necessary and follow up control with ultrasonography is sufficient. In other cases with a low part of fat histological examination cannot be missed. Angiography is not helpful for the differentiation from a malignant tumor.

Angiography, Digital Subtraction↗
PubMed1989

Relapsing poly(peri)chondritis associated with fibrosing alveolar disease and antibodies to pneumocytes type II and Clara cells.

A 62-year-old man with histological confirmed relapsing polychondritis showed chondritis of ears and nose, arthritis, keratitis and a hemolytic anemia. The bronchoalveolar lavage, computed tomography of the thorax and pulmonary function tests disclosed findings compatible with fibrosing alveolar disease. IgG antibodies to alveolar pneumocytes type II and bronchiolar Clara cells were detected by indirect immunofluorescence of human lung tissue. To our knowledge this is the first report of fibrosing alveolar disease in relapsing polychondritis and detection of antibodies to human pneumocytes type II and Clara cells.

Autoantibodies↗
PubMed1989

[Sweet syndrome in chronic myeloid leukemia].

A 31-year-old woman with chronic myeloid leukemia developed bullous skin changes not responding to antibiotic therapy. A biopsy showed a sterile predominantly neutrophilic infiltrate consistent with Sweet's syndrome. These skin changes responded well to methylprednisolon. Seven months later the patient died in a blast crisis.

Adult↗
PubMed1988

[Actinomycosis of the skin in HIV infection].

A 29-year-old woman with HIV-infection developed disseminated abscesses of the skin, identified as an infection with Actinomyces israelii. To our knowledge, actinomycosis associated with HIV-infection (AIDS-related complex) has been reported only once previously.

AIDS-Related Complex↗
PubMed1988

[Cytomegalovirus infection as a cause of intestinal perforation].

Three male patients with the acquired immunodeficiency syndrome revealed perforations of the intestine (jejunum-ileum; colon ascendens; coecum). The cause was necrosis due to cytomegalovirus infection. The characteristic findings were cytomegalic inclusion bodies in endothelial cells of the capillaries. These lesions caused alterations of the microcirculation. Therefore it seems reasonable to conclude that in these cases necrosis and perforation were due to ischemia. Cytomegalovirus infection must be taken into consideration in any patient with the acquired immunodeficiency syndrome and gastrointestinal ulcerations.

Acquired Immunodeficiency Syndrome↗
PubMed1986

[Granulomatous gastritis of the antrum in generalized sarcoidosis].

A 42-year-old man had a 4 year history of sarcoidosis stage II (lung). In biopsied specimens of the antrum we found epithelioid granulomas caused by gastric involvement in sarcoidosis. Coincidentally we found a gastric ulcer which was later the source of gastric bleeding. The granulomas were located around this ulcer and also under intact mucosa. Therefore, in our opinion it was not the case that granulomatous gastritis caused the ulceration in a direct way. We saw a connection between hypercalcemia--often found in patients with sarcoidosis, as in our patient--and the gastric ulcer. Therapy was thus aimed at lowering the blood calcium concentration. Steroids were avoided at this time. The ulceration healed, although granulomatous gastritis continued.

Biopsy↗
PubMed1981

Short term changes of glycosylated haemoglobins during glucose administration in healthy and diabetic subjects.

Haemoglobin A1 (Hb A1) is becoming a routine parameter for monitoring diabetic metabolism. Although widely used, the kinetic relationship between glucose concentration and Hb A1 value is not clarified yet. In vivo biosynthesis of Hb A1 was studied in 30 patients during an oral glucose tolerance test. Ten diabetics received an i.v. injection of 0.5 g glucose/kg, 20 healthy students and infusion of 1.0 g and 1.5 g glucose/kg and hour for 6h, and six volunteers 2.0 g/kg and hour. A parallel increase and decrease of serum glucose levels and Hb A1 could be demonstrated beginning a few minutes after administration of glucose. These acute changes of Hb A1 are closely related to fluctuation of serum glucose probably representing the formation and dissociation of the labile aldimine-linkage between haemoglobin and glucose. Severe hyperglycaemia of 6 h duration is not sufficient to cause an elevation of stable glycohaemoglobin.

Diabetes Mellitus↗
PubMed1981

[Mineral content of the peripheral skeleton in patients with diabetes mellitus ].

In order to determine the effect of diabetes mellitus on bone mineral content, measurements with the iodine 125 isotope method of Cameron were carried out in the distal ulna and calcaneus of 40 patients. 38% of female and 20% of male diabetic patients showed abnormally low values. The most severe changes were found in patients with complications of diabetes. There was a correlation between the duration of the diabetes and the severity of the mineral loss.

Adult↗