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H Dörfler

Publications and source records attributed to H Dörfler.

34 records · Page 2Linked to original sources
PubMed1977

The early phase of insulin release in man--a new method for quantitative analysis.

A method is presented for the quantitative analysis of early insulin release in man. There were measured arterial insulin levels after glibornuride administered intravenously. The mathematical procedure has been modified: Modification I is based on the assumption that early insulin release represents a wave like insulin delivery, modification II is based on the assumption that this insulin bolus is immediately followed by a slower insulin release which must be distinguished from the second phase of insulin release. For the calculations there was used a "primary insulin space" derived from experiments with exogenous insulin. The results of calculations were varying up to 1.5 units of early insulin release in healthy volunteers receiving glibornuride with dosages varying up to 50 mg. The value of the presented method for examinations of insulin release for theoretical and clinical purposes is discussed.

Adult↗
PubMed1977

Muscle capillary basement membrane thickness in lipoatrophic diabetes.

A 21 years old female patient with lipoatrophic diabetes, a distinct syndrome of insulin resistant diabetes mellitus, loss of subcutaneous fat, hepatosplenomegaly, hyperlipidemia, increased basal metabolic rate, subvalvular aortic stenosis and cystic bone lesions is described. She exhibited all clinical signs of diabetic microangiopathy. Quantitative estimation revealed severely thickened basement membranes of muscle capillaries. It is concluded that the extent of her microangiopathy is a consequence of her excessive metabolic abnormalities.

Adult↗
PubMed1975

[Lipoatrophic diabetes. Report of a case (author's transl)].

Lipoatrophic diabetes is characterized by: complete lack of subcutaneous fattissue (generalized lipodystrophy), insulin resistant diabetes mellitus, hepatosplenomegaly, excessive hyperthyroidism, elevated basal metabolic note without hyperthyroidism. Recently, "cystic" alterations in the bone have been described as a possible further characteristic. The case of a young woman, now aged 21, who has had generalized lipodystrophy for 17 years and overt diabetes mellitus for 6 years is reported.

Adult↗