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Biomedical subjects

H Diederichsen

Publications and source records attributed to H Diederichsen.

At least 19 recordsLinked to original sources
PubMed1988

Liver transplantation in a 48-year-old female with primary biliary cirrhosis.

In 1983, a Danish female with primary biliary cirrhosis underwent orthotopic liver transplantation (OLT). The transplantation took place in Groningen under a Danish-Dutch cooperation, at this writing, and more than four years after transplantation, the patient is still alive. The quality of her life has been dramatically improved, making possible her return to work. Liver tests, liver function, and biopsies are normal and without signs of development of primary biliary cirrhosis in the transplanted liver. Liver transplantation is now frequently performed at several centres throughout the world with an increasing success rate. In Scandinavia, centres have been established in Norway, Finland, and Sweden, whereas in Denmark the organisation of a programme for liver transplantation is still being discussed. Because of the extremely high costs, liver transplantation has to be approved medically and politically, and the brain death criteria have to be accepted before it can be considered as a generally accepted modality of treatment.

Female↗
PubMed1986

Plasma concentrations of complement split product C3d and immune complexes after procainamide induced production of antinuclear antibodies.

Seventeen patients treated with procainamide for cardiac ventricular arrhythmias were followed for up to 40 weeks. Immunological data as a clue to developing the systemic lupus erythematosus (SLE)-like syndrome was emphasized. Ten patients developed antinuclear antibodies (IgG or IgM), but no increase in the plasma concentration of the complement split product C3d or immune complexes, measured by two different methods, was demonstrated. This finding is in contrast to the high levels of both C3d and immune complexes in SLE. The discrepancy may be caused by a lack of immune complex mediated complement activation by the procainamide induced antibodies, or may be due to a difference in severity of disease. The acetylator phenotype of the patients was determined but due to the low frequency of fast acetylators no comparison of the immunological response of the two phenotypes could be done.

Aged↗
PubMed1986

Antibodies to isolated hepatocytes in chronic active liver disease. Identification and diagnostic significance of bile canalicular antibodies.

A branched or net-like immunofluorescence pattern was demonstrated across the surface of isolated rabbit hepatocytes. We presume that this staining pattern is related to bile canaliculi on the cell surface, since it was closely correlated with the presence of bile canalicular antibodies, as detected by immunofluorescence on liver sections. Reaction with the putative bile canaliculi on rabbit hepatocytes was produced by 20 of 26 sera from patients with chronic active liver disease, 13 of 120 sera from patients with various liver diseases, and 1 of 40 normal blood donor sera.

Adolescent↗
PubMed1985

Thyroid function after resection for non-toxic goitre with special reference to thyroid lymphocytic aggregation and circulating thyroid autoantibodies.

A series of 91 patients operated on for non-toxic goitre was followed systematically during 24 months post-operatively with regard to thyroid function. A thyroid remnant of at least 5 to 8 g was left in the majority of cases, and thyroid replacement was not given. Histopathological grading was performed on goitrous specimens with reference to lymphocytic infiltration. Thyroglobulin antibodies and thyroid microsomal antibodies were determined pre-operatively. Goitre resection provoked a high, but transient increase in serum thyroid stimulating hormone (TSH) levels with peak values 3 to 6 months after operation. Twenty-four months after surgery serum TSH values had normalized, but were still slightly elevated in patients with bilateral surgery and high lymphocytic infiltration, 9% of the patients. The concentration of serum free thyroxine index (FT4I) and serum total triiodothyronine (TT3) decreased after operation, but within reference range. Twenty-four months after surgery, serum FT4I was back to baseline values, while serum TT3 was still lowered compared to the pre-operative level. None of the patients developed overt hypothyroidism. Occurrence of circulating thyroid autoantibodies was not related to post-operative changes in thyroid parameters. We conclude that thyroid replacement therapy seems not to be indicated routinely following resection for non-toxic goitre, but precaution should be taken in case of bilateral resection and high lymphocytic infiltration of goitrous specimens.

Adolescent↗
PubMed1985

Petechiae and vasculitis in asymptomatic primary biliary cirrhosis.

Recurrent petechiae of the lower legs and signs of asymptomatic primary biliary cirrhosis have been found in three women. Large immune complexes were identified in the serum of three and cryoglobulin/cryofibrinogen in two. Histological examination of skin biopsies revealed a leukocytoclastic vasculitis in all three patients. Direct immunofluorescent studies showed deposits of IgM, C3 and fibrinogen in and around the walls of the small vessels of the skin of two and C3 as well as fibrinogen in one patient. It is suggested that leukocytoclastic vasculitis may be a microscopic feature of the systemic involvement in asymptomatic primary biliary cirrhosis, and petechiae the clinical manifestation.

Aged↗
PubMed1985

The significance of platelet-associated immunoglobulin G in non-thrombocytopenic patients with systemic lupus erythematosus.

The possible pathogenetic significance of platelet-associated immunoglobulin G in systemic lupus erythematosus (SLE) has been studied, using a semiquantitative immunofluorescence technique. The study included 22 patients suffering from SLE during the period 1973-81. Thirteen patients had various clinical and/or laboratory signs of disease activity at the time of investigation, but none showed thrombocyte values below the normal range. A positive reaction for platelet-associated immunoglobulin in serum (indirect PlIgG) was demonstrated in 73 percent of the cases and in two patients on their own platelets also (direct PlIgG). The study included investigation of ANA (80% positive) and anti-DNA (positive in three patients only). A significant negative correlation was found between indirect PlIgG and platelet count and between ANA (/IgG or IgM) and platelet count. Indirect PlIgG correlated with known expressions of disease activity, as high ESR and low Hb, and in patients with direct PlIgG, several markers of disease activity were found to be present. It is concluded that PlIgG may be of pathogenetic importance and can be used as a marker of disease activity.

Adolescent↗
PubMed1984

Release of platelets into the circulation induced by gamma globulin treatment in a case of idiopathic thrombocytopenic purpura.

The kinetics and distribution in vivo of 111In-labelled platelets prior to and during intravenous high-dose gamma globulin therapy in a 3-months-old child with idiopathic thrombocytopenic purpura were evaluated. Concomitantly with a prompt increase in platelet concentration we found evidence for release of platelets into the circulation, presumably to a large extent originating from the spleen and liver. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system.

Blood Platelets↗
PubMed1983

Arthritis in patients with antimitochondrial antibodies.

We describe the clinical and radiographic findings in 15 women with antimitochondrial antibodies (AMA) without clinical liver disease. Arthralgias appeared in their third or fourth decade and typically involved the small joints of the hands with periarticular swelling and cortical erosions. Few hand nodes, deformation, or sclerodactyly. Four had histologic primary biliary cirrhosis (PBC). The association between arthritis and PBC is discussed. The arthritis and PBC may be two manifestations of some general underlying disease process, AMA being a marker. Patients with atypical arthralgias affecting the hands should have the AMA test performed in view of the possibility that this affection might accompany or progress to PBC.

Adult↗
PubMed1983

Demonstration of organ-nonspecific antigens in liver-specific protein.

Liver-specific protein was isolated from bovine, rabbit, and human liver. A corresponding kidney protein was isolated from rabbit kidney. The liver-specific protein and kidney-specific protein were coupled to activated CH-Sepharose 4B. Affinity chromatography was performed on columns of liver-specific protein and kidney-specific protein CH-Sepharose 4B, with sera containing antimitochondrial antibodies, smooth muscle antibodies, bile canalicular antibodies, reticular tissue antibodies, and antinuclear antibodies. The material eluted from the affinity chromatography columns was studied for immunofluorescence reaction against sections of liver, kidney, and stomach. Reactions were found of the liver-specific protein and kidney-specific protein column eluates against mitochondria, smooth muscle, double-stained bile canaliculi, reticular tissue, and nucleoli. Thus, the antigens belonging to these cell and organ constituents must have been present in the liver-specific protein (and kidney-specific protein) preparations, indicating that liver-specific protein is not a pure liver cell membrane-specific protein.

Animals↗
PubMed1982

Reaction against liver cells by human antiactin antibodies purified by affinity chromatography.

Human antiactin antibodies were isolated from human smooth muscle antibodies by affinity chromatography using actin extracted from rabbit striated muscle and coupled to activated CH-Sepharose 4B. The eluate contained IgG and IgM smooth muscle antibodies reacting against muscularis mucosae of the stomach and blood vessels. Further the eluate contained IgM antibodies acting against the surface of isolated hepatocytes and the periphery of hepatocytes of sections of liver cells. These results indicate that antiactin antibodies possibly react with the hepatocyte membrane as has been described with regard to other antibodies.

Actins↗