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Biomedical subjects

H Diederichsen

Publications and source records attributed to H Diederichsen.

36 records · Page 2Linked to original sources
PubMed1980

Anti-actin antibodies revealed by counter-immunoelectrophoresis. Relation to smooth muscle antibodies and bile canalicular antibodies.

In investigations by counter-immunoelectrophoresis, anti-actin antibodies were found in 59% of patients with chronic hepatitis and in 8% of patients with non-hepatic diseases and normal blood donors. Anti-actin antibodies were found more frequently in patients with hepatitis and IgG smooth muscle antibodies than in other groups of diseases and normal subjects with IgG smooth muscle antibodies. Anti-actin antibodies showed no correlation with bile canalicular antibodies.

Actins↗
PubMed1977

Mitochondrial antibodies without antinuclear antibodies in non-hepatic diseases.

The term "pseudo-LE syndrome" was previously used to describe an SLE-like disease in which AMA, but not ANA, were found in serum. In an attempt to find patients with this syndrome, we tested 9 358 sera for AMA and ANA. AMA without ANA was found in six patients without liver disease. One of these patients had an SLE-like disease. Two of the others had diseases of the thyroid and one had rheumatoid arthritis--diseases in which AMA have previously been described. One patient had allergic vasculitis and one hypercholesterolaemia; these diseases are not known to be associated with the presence of AMA.

Aged↗
PubMed1977

Peripheral immunofluorescence of hepatocytes. Relation to smooth muscle antibodies and bile canaliculi.

By means of indirect immunofluorescence microscopy, a peripheral fluorescence reaction with hepatocytes was found, surrounding the entire cell, with sera from patients with cancer and acute hepatitis and from normal blood donors. It was proved that this reaction was not related to bile canaliculi, contrary to bile canaliculi antibody demonstrated previously from patients with chronic active liver disease. By using fluorescein-conjugated anti-human IgG, the reaction with the periphery of the hepatocytes was produced to a more or less pronounced degree with almost all sera studied. The reaction seems not to be directed against contractile proteins on the liver cell membrane as only a minor part of these sera had also IgG smooth-muscle antibody, and anti actomyosin antibody obtained by affinity chromatografy did not react with the hepatocyte. When applying fluorescein-conjugated anti-human IgM the reaction with the periphery of the hepatocytes was observed in one fourth of the patients with acute hepatitis and only sera which contained also IgM smooth-muscle antibody.

Animals↗
PubMed1975

Investigations for skin antibodies in malignant neoplasms.

A group of 451 patients with various malignant neoplasms was investigated for the presence of antibodies against the intercellular substance in epidermis and against the basement membrane in the skin, using the immunofluorescence method. None of the patients had bullous disease. Circulating basement membrane antibodies were found in a 63-year-old man with lung cancer. None of the patients had antibodies against the intercellular substance. No in vivo bound intercellular or basement membrane antibodies were found.

Antibodies, Neoplasm↗