[Intellectual development of at-risk children--results of the Rostock longitudinal study after 10 years].
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Biomedical subjects
Publications and source records attributed to H Engel.
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This double-blind and cross-over study was designed to compare the effect of domperidon, metoclopramide and bromopride on esophageal motility. A stimulating effect on lower esophageal sphincter pressure (LESP) was shown after i.v. bolus of all three substances, not after saline (control period). LESP was rised significantly up to 50 min above basal levels. Motility pattern of the esophagus was also stimulated up to 50 min.
The dyspraxia test developed by LESNY was applied in a random test in 279 six-year-old risk and control children fit for infants class. All children showing failures with respect to dyspraxia requirements have on average higher pregnancy and birth risks, have on an average more symptoms of the cerebral-psychic axis syndrome, produce pathological findings more frequently in the usual method of somatic brain stem diagnostics and are regularly below the level of the control group with respect to the various performance, concentration, and behaviour parameters. Mild dyspraxia is characterised by elementary functional weakness which is etiologically caused by a brain injury and psychopathologically exerts a general development-inhibiting effect.
The data given in the literature about frequency and relative importance of diagnostic criteria for children with cerebral lesions show considerable differences and so do, as a consequence, diagnosing practice and epidemiological statements. This study aims at weighting the determing factors of a diagnosis and ascretining their interrelations and the associated influence on the psychic-mental development. In a total of 279 six-year-old risk and control children eight criteria regarding brain damage were recorded. The conclusive results give evidence of the influence exerted by organic conditions on the child's development and of the possibility of objectification by common methods. There is no justifiable alternative to a primarily organic basis of the diagnosis of infantile brain damage.
The authors present a factor analysis of 49 psychic and physical peculiarities found in 294 children in creches, most of them high-risk children; these were perinatologically classified at the time of birth, and an examination was performed by neuropsychiatrists and a follow-up clinical and psychological examination made, at the age of 2.0-2.3 years. The following two problems were of interest: 1. Can psychosyndromes be detected in creche children and, if so; 2. Does the psychosyndrome obtained through factor analysis contain vegetative symptoms? Results - The peculiarities can be grouped as follows: (table; see text) This is the first time that the existence of a pre-school chronic psychosyndrome has been detected using a multivariate method. Its basic structure is as described by Göllnitz. A discussion follows of its position within the symptom variability in damaged and disturbed children, and of rough brain localization analogies.
Using the questionnaire that has been specifically developed to obtain data on parental educational behavior, 294 mothers of 2-year-old children were studied and their attitudes towards corporal punishment correlated with characteristics and symptoms of children as well as with psychosocial factors. Low level of education and lack of domestic happiness proved to be essential conditions for acceptance of corporal punishment. Children with developmental disorders are especially endangered only because of their particular liability to disorders, but on account of the fact that they do not receive the same amount of clemency as do children who are liable to infections. Problems of maleducation should receive greater attention in the elimination of environmental dangers to healthy development of children as well as in counseling.
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An allergic agranulocytosis developed after promethazine administration to a 34-year-old man with a compulsion neurosis. Promethazine-specific leucocyte antibodies were demonstrated in the antiglobulin consumption test. Four similar cases, reported in the literature, are discussed in relation to this personal case. The findings are contrasted to the majority of cases of toxic "phenothiazine agranulocytosis".
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As a casuistic contribution to differential diagnosis of thrombosis of cerebral veins and sinuses a case of occlusion of sinus sagittalis superior by infiltration of an intracerebral metastasis from a teratoma of testis is reported. The leading symptoms - epileptic seizures, progressive hemiplegia, choked papilla and clouding of consciousness - gave rise to the tentative diagnosis of a cerebral tumor; in carotis angiography however, the metastasis was not detected, merely the occlusion of the sinus was demonstrated. Therefore the progress of the syndrome was misinterpreted as caused by an advancement of a venous thrombosis. Only autopsy showed the symptomless primary tumor and its formation of metastases.
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