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Biomedical subjects

H Frahm

Publications and source records attributed to H Frahm.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Frequency and distribution of risk factors in hearing loss].

In 45 patients with hearing loss we found metabolic and other "risk factors" above average. In 96% of those patients there was one "risk factor" at least. Latent (63.8%) or manifest diabetes (6.6%) was most frequent. Hyperuricemia was observed in 35.9% and hyperlipoproteinemia type IIa/IIb or IV in 24.2%. Non-metabolic risk factors (overweight, elevated blood pressure, smoking, stress) were found in 80% of the patients. It seems possible and more likely that hearing loss is caused by "risk factors" and consecutive vascular complications of the inner ear than by neurologic or orthopedic diseases. The diagnosis "hearing loss" should motivate the otologist to look for "risk factors" by interdisciplinary cooperation.

Adolescent↗
PubMed1976

[Treatment of hyperlipoproteinaemia types IIa, IIb, IV and V with a combination of clofibrate and inositol nicotinate (author's transl)].

Treatment of 14 patients over eight weeks with a combined preparation containing 250 mg clofibrate and 180 mg inositol nicotinate resulted in a decrease of serum-cholesterol level of 20% and of serum triglyceride levels of 40%. The same effect was obtained in 22 patients by clofibrate alone in double doses. There was no significant difference in effect between the two preparations. Doubling the dose of the combined preparation in ten patients did not increase the lipid-lowering effect. After the combined preparation had been stopped triglycerides rose more slowly than after stopping clofibrate alone. There was no difference with regard to the rise in the cholesterol levels. The combined preparation lowered serum lipids regardless of the type of hyperlipoproteinaemia, but the extent was less with types IIa and IIb (n =15) because of the lower initial value, than in those with types IV (n = 26) and V (n = 3).

Cholesterol↗
PubMed1976

The development of a radioimmunoassay for arginine vasopressin.

The development of a sensitive and specific radioimmunoassay for vasopressin is described. Antibodies were successfully produced following the coupling of synthetic arginine vasopressin with bovine serum albumin carried out with carbodiimide. In order to standardize the assay, the labelled hormone has to be separated twice using a DEAE-Sephadex-A-25 column and thin layer chromatography with cellulose plates. A further condition to obtain a reproducible standard curve is the use of a pure arginine vasopressin checked by cellulose chromatography. Most of the vasopressin batches available do not fulfil this requirement of purity. With the method described, vasopressin can be determined in unextracted human urine. The lower limit of detection is 2 pg/ml. Normal values are in the range of 67.5 +/- 34.3 ng/24 h (kappa +/- SD, n =45). No significant difference of AVP excretion was found between men and women. The usefulness of the assay is demonstrated in patients with hypothalamic or pituitary disorders.

Acromegaly↗
PubMed1976

[Comparative volumetry of brains from wild and captive tree shrews (Tupaia)].

The changes in brain weight and composition during captivity were investigated in two groups of tree-shrews (Tupaia). One group consisted of wild animals whose brains were dissected and weighed immediately after trapping in Thailand. The second group (F1) consisted of animals reared in captivity whose parents originated from the same populations of Thailand animals as the first group. Wild- and F1-animals showed no significanct differences in body weight; however, the brain weight was significantly greater in F1-animals. This is in clear contrast to the results of former investigations of other species, in which the brain size became reduced in captivity. Of the various brain parts, the absolute volumes of the cerebellum and the telencephalon, and, within the latter, those of the striatum, schizocortex, neocortex, and area striata were enlarged significantly in animals reared in captivity. A significant decrease was observed in the complex of paleocortex + amygdala, and a possible decrease in the hippocampus. An attempt to interpret the changes was made with regard to differences in age-composition between the two groups, different nutrition and motor activities, heterochronies in the ontogenetic development, and, finally, different environmental influences during ontogeny.

Age Factors↗