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Biomedical subjects

H Frisch

Publications and source records attributed to H Frisch.

At least 181 records · Page 10Linked to original sources
PubMed1978

[Heroin-withdrawal-syndrome in the newborn (author's transl)].

A case of a heroin-withdrawal-syndrome is reported. Diagnostic, therapeutic and social aspects of this syndrome are discussed. Newborn infants delivered from mothers addicted to heroin often develop a deprivation syndrome. 40% of these children are small for date babies. Symptoms of deprivation begin after delivery or between the 1st and 4th week of life. Generally the onset of symptoms lies between the 1st and 3rd day of life with irritability, tremor, restlessness, and shrill cry. The degree of illness depends upon mother's last heroin intake. Treatment for drug addicts are tinctura opii (3--5--10 drops orally following 4 hours) and Chlorpromazine (2,2 mg/kg/25 hours orally or i. m.). The mortality rate increases when treatment is missing.

Electroencephalography↗
PubMed1978

[Thrombosis of the renal artery in a newborn (author's transl)].

Very rare informations about thrombosis of the renal artery in newborns in the literature could be found. In a six years old girl in the course of a perinatal asphyxia complicated by shock a renal artery thrombosis was observed. Profuse bleeding, anemia, thrombopenia, prolonged bleeding time and coagulation time and a low percentage of the thrombotest suggested an intravascular coagulation as a possible factor of this disease. The treatment of the coagulopathia was effective. The physical and psychical development of the girl is normal. The inhibition of the renal function, however, is in a compensated state.

Child Development↗
PubMed1978

[Thanatophoric Dwarfism (author's transl)].

Four cases of thanatophoric dwarfism which appeared between 1974 and 1977 are described. Thanatophoric dwarfism was firstly described in 1967. In the mean-time there are reports about 44 cases. The frequency of thanatophoric dwarfism is considered to be 1 to 6393 newborns. There is no clear evidence about the occurrence of thanatophoric dwarfism, chromosone patterns have been always normal. This type of dwarfism is differentiated from other similar syndromes.

Diagnosis, Differential↗
PubMed1978

[Prevention of neonatal apnea with theophylline (author's transl)].

To the well known methods for prevention of neonatal apnea like stimulation, CPAP, and mechanical ventilation the treatment with theophylline has been added recently. We studied the efficiency of theophylline therapy in 10 premature infants with apnea. The initial dosage was 6 mg theophylline/kg body-weight, followed by a dosage of 2 mg/kg for the next 12 h. The frequency of apnea thereby was significantly reduced. Only in two cases the heart rate rose above 180/min as a side effect. In no case an additional therapy was necessary.

Apnea↗
PubMed1977

Response of gonadotropins to stimulation with luteinizing hormone -- releasing hormone (LH-RH) in children with precocious puberty before, during and following therapy with cyproterone acetate or an ethisterone derivate.

9 children with precocious puberty were treated over a period of 6 months to 6 3/12 years with Cyproteron acetate or an Ethisterone derivate. LH-RH tests with radioimmunological estimations of LH and FSH were performed before therapy was begun, during and after completion of treatment. In children with untreated precocious puberty the mean basal LH levels were the same as in normal prepubertal children but the increase and the peak values after i.v. LH-RH were found to be considerably greater than in normals. In the treated patients this stimulatable LH release was suppressed; after completion of therapy it was again elevated. The basal FSH levels in untreated children were elevated; however the increase and the peak values were comparable to the collective norm. Results were not altered considerably by therapy, however these parameters were given elevated after completion of therapy. Despite the marked suppression of stimulatable LH by therapy acceleration of bone age is practically not affected. After completion of therapy this drug-induced suppression of gonadotropines is promptly reversible.

Age Determination by Skeleton↗
PubMed1977

[Influence of the age of old primiparae on the perinatal infant morbidity and mortility (author's transl)].

157 old primiparae (greater than 30 a) have been compared to a randomised control group of primiparae between the 16th and 30th year of age. In addition to the perinatal infant mortality rate, the number of children with malnutrition, the frequency of premature babies, the presence of a low Apgar score (less than or equal to 7) and pathological pH-values in the umbilical artery (pH less than or equal to 7,10) were cheked. Moreover the frequency of early neonatal morbidity (presence of one of the following criteria: 1 minute Apgar score less than or equal to 7, pH of the umbilical artery less than or equal to 7, 10, a transitoric or severe RDS and neurological complications during the newborn period) was investigated in both groups. In the group of the old primiparae a significantly higher perinatal infant mortality rate was found compared to the control group (3,8% versus 0,6%, p less than 0.05). The rate of small for date babies was remarcably higher than in the control group (14,6% versus 6,4%, p less than 0.05). There was no difference in the prematurity rate in both groups. The children of old primiparae had more frequently a low Apgar score (less than or equal to 7) than infants of the randomised control group (18,5% versus 11,5%), but the difference is statistically not significant. Furthermore no difference in the number of pathological pH values in the umbilical arteries (pH less than or equal to 7, 10) were found in the both groups. The children of old primiparae show a higher early neonatal morbidity rate compared to the control group (21.7% versus 14.0%); however, the difference is statistically not significant. According to our results the risk for the newborns is increased already with primiparae over 30 rather than 35 years of age.

Adult↗
PubMed1977

[Cerebral gigantism (Sotos-syndrome) (author's transl)].

Case report of a nine month old girl with Cerebral Gigantism. It is a gigantism syndrome characterized by advanced bone age, a typical craniofacial dysmorphia and a not progredient mental retardation. Etiology and pathogenesis of this syndrome are unknown.

Abnormalities, Multiple↗
PubMed1977

[A new antigonadotropin in the treatment of precocious puberty and pubertal gynaecomastia (author's transl)].

A synthetic steroid compound derived from testosteron (isoxazol-ethisterone), Danazol, with gonadotropin-depressing activity, was used in the treatment of 4 cases of idiopathis sexual precocity (age 2 1/2 to 4 years) and in 10 cases of severe pubertal gynaecomastia. In sexual precocity the suppression of menstruation as well as of breast-enlargement was good, while the suppression of acceleration of longitudinal growth and bone maturation was inferior compared with cyproteron-acetate. In most boys with gynaecomastia a marked regression of breast enlargement occurred within a few weeks or months. With the dosage used (200-300 mg/day in the sexual precocity patients, 300-400 mg in the gynaecomastia patients) the changes in plasma hormone levels (LH, FSH, progesterone, estradiol, testosterone) were within a non significant range. Depression of testosterone seemed to be a rather regular finding. No untoward side-effects of the medication were noticed in the 14 patients studied. In summary, Danazol did not show any advantages compared with the compounds used in the treatment of isosexual precocity sofar. In contrast, the drug proved to have useful effects in pubertal gynecomastia, a condition which in severe degrees certainly deserves medical treatment.

Adolescent↗
PubMed1977

[Complete parenteral nutrition in childhood].

Complete parenteral nutrition by means of continuous intravenous drip into large veins, over a long period, has already shown itself to be of therapeutic use in the field of pediatrics. While the nutritional-physiological aspect of this therapeutic method is clear -- it depends on an accurate and sufficient supply of water, salts, glucose, amino-acids, triglycerides and essential fatty acids, vitamins and trace elements -- in practice it presents difficulties which though often serious are not insurmountable. Especially are to cite the septic complications, which are nearly imperceptible during their development. They are only to accept in view of the often almost hopeless condition of the child, who would be lost without complete parenteral feeding. Similar problems arise through metabolic complications which are caused non rarely only by insufficient dosages and lack of careful supervision but it is generally possible to correct these at an early stage. Complete parenteral nutrition must be exactly indicated. It is indeed a great therapeutic help, particularly when over a longer period -- at least a week or longer -- oral nutrition is impossible or insufficient. Practicall experiences will be reported. A retrospective assessment of 50 cases has shown the tendency (through taking too much care?) to hold the quantity of liquids and supply of calories too short and to administer too much carbohydrates and too little fat.

Adolescent↗
PubMed1977

[Treatment of severe Rhesus erythroblastosis].

Report about the management of cases of severe Rhesus erythroblastosis. One case is specially discussed because of it's actuality. This was a patient with severe Rh-sensitization (OOD at 450 mm from the beginning of the 30th week of gestation in zone III according to Liley). Because of the haemolytic disease and the chronic fetal distress the Caesarean section was already performed in the 32nd week of gestation after Betamethason treatment of the mother. The Lecithin-Sphingomyelin (L/S) ratio in the amniotic fluid as a criterium of fetal lung maturity raised almost twicefold (from 0.9 to 1.6) after Cortison treatment. The intensive care (assisted ventilation with PEEP, correction of the acidosis and transfusion of packed red cells) of the severely anaemic (Hb 3.5 g%, Hk 15 vol.%) and hydropic newborn was already started in the delivery room. The newborn developed no RDS and was discharged healthy. With reference to this and other cases the management of severe Rh-sensitization before the 34th week of gestation is discussed. Premature infants are mainly susceptable to the development of a Respiratory Distress syndrome (RDS). After antepartum Cortison treatment for prevention of an RDS the date of confinement should be arranged earlier. The value of an early Caesarian section after antepartum Glucocorticoid treatment as compared to the application of intrauterine transfusions in cases of severe erythroblastosis is discussed. It is also reported about recent methods of treatment of severe conditions of hydrops fetalis.

Austria↗
PubMed1977

[Acid-base balance during exchange transfusion (author's transl)].

During exchange transfusion with ACD blood severe metabolic acidosis may occur. ACD blood contains increasing amounts of acid which depends on the age of the blood. The mature newborn infant has different ways to compensate metabolic acidosis: the lungs, the immature kidneys and the conversion of citrate to bicarbonate. In preterm infants as well as in newborns with respiratory distress syndrome and mechanical ventilation the compensatory mechanisms may be reduced or even absent. Therefore ACD blood may lead to severe complications. To prevent acidosis adequate buffering with TRIS is recommended.

Acidosis, Respiratory↗
PubMed1977

Evidence for genetic control of anti-insulin immunity in juvenile onset diabetes mellitus.

The role of genetic factors in humoral anti-insulin-response was studied in 87 patients with juvenile onset diabetes. A significant insulin antibody formation was found in 76 (87%) juvenile diabetics. By dividing these patients in four groups according to different heights of insulin antibody levels (non-, low-, moderate- and high-responders) a positive or negative correlation between humoral anti-insulin response and certain HLA antigens could be found. Non-responders showed a close association with HLA-B7 positivity, whereas in the insulin high-responder patients, a considerable decrease of HLA-B8 and increase of HLA-Bw15 and HLA-Cw3 was found. These findings indicate that certain genetic constellations within the HLA complex might have an important part in determining humoral anti-insulin immunity.

Adolescent↗
PubMed1977

[Polycythemia in the newborn infant (author's transl)].

Respiratory distress syndrome and cyanonis in newborns (first neonatal week) may be caused by polycythemia. During 14 months twentyone newborns with symptoms of cardiorespiratory or neurological distress caused by polycythemia on the neonatological division of our hospital were observed. The values of hemoglobin ranged between 22.7 and 28.6 g% (mean 25.65 g%), the values of hematocrit ranged between 72 and 90% (mean 81%). The central venous hematocrit measured on 14 patients ranged between 65 and 77% (mean 71%). On 20 newborns isovolemic haemodilution by 5% plasma was performed. The volume of exchange was calculated according to the formula: Sign and symptoms seemed to improve rapidly following treatment, clinically reflecting the fall in hemoglobin and hematocrit.

Exchange Transfusion, Whole Blood↗
PubMed1977

[Screening for hypothyroidism in the newborn with a total T 4-RIA method (author's transl)].

A screening method for detection of congenital hypothyroidism is presented in detail in cooperation with the "Austrian Program for Inborn Errors of Metabolism". Screening is performed by measuring the total T4-content of 1/8 inch filter paper dots filled with dried blood of newborns. The strategy for recall of newborns with borderline or pathological T4-values used, results in a definite diagnosis on day 55 of life. The advantages of additional TSH determination in the filter paper dots are discussed. So far (Sept. 1976) 8645 newborns have been investigated, covering the regions of Vienna and Carinthia (Austria). Preliminary studies reveal a slight dependency of the measured T4-values on the day of sampling. Two congenitally hypothyroid children have been diagnosed so far, corresponding fairly well with the reported frequency in the literature (1 : 6000).

Humans↗
PubMed1976

[An unusual hormone-active avarian tumor in a 3-year-old girl].

A case report on an unusual hormone producing ovarian tumor in a 3 year old girl with sexual precocity is given. The serum values of Estradiol and Progesterone were similar to those of mature women during the luteal phase. The LH values were normal, the 17-Ketosteroids and 17-Hydroxycorticosteroids were near the upper limit of the normal range. At laparotomy a smooth, encapsulated tumor of the left ovary, 12 cm in diameter, was removed by unilateral salpingo-oophorectomy. Hormone analyses of the blood of the ovarian vein as well as of necrotic parts of the tumor showed values of 3450 and 2750 pg/ml Estradiol, and 70 000 and 75 000 pg/ml Progesterone respectively. Histiologically the tumor cells were growing in nests and broad columns, showing bizarre nuclei, abundant pathologic mitoses and patchy calcification. In places the tumor cells were forming follicle-like structures. Both the fat stain and the glycogen stain were positive. Histochemically the tumor showed a strong activity of 3beta-ol-Steroiddehydrogenase. Postoperatively the signs of sexual precocity disappeared soon. The patient is now without complaints for 3 years. The diagnosis of a juvenile granulosa cell tumor (Scully) was given. The endocrine relations between sexual steroids and gonadotropin before and after surgery are discussed.

Child, Preschool↗
PubMed1976

[Reduction of expected height in excessively tall boys (author's transl)].

4 boys with familial tall stature aged 119/12-153/12 years were treated with Testosterone for reduction of definitive height by accelerating epiphyseal fusion. Body height at the beginning of therapy was 3,2-5,4 standard deviations over the mean, the height prediction was 199-205 cm. In therapy oral Methyltestosterone was used in the beginning and therapy was later continued with Testosterone oenanthate i.m. as depot preparation. The average duration of treatment was 14 months; in this time bone age was accelerated 2,3 times: a mean reduction of 8,9 cm from the predicted height was the result. No severe side effects could be observed.

Abnormalities, Multiple↗