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Biomedical subjects

H Frisch

Publications and source records attributed to H Frisch.

At least 163 records · Page 9Linked to original sources
PubMed1980

[Congenital german measles encephalitis (author's transl)].

German measles is an infections exanthematous disease, long regarded as completely harmless. The clinical symptoms are banal and often go unnoticed. In complete contrast is the severe malformation of the embryo after infection early on in pregnancy, first discovered by Gregg in 1941. The virus infects the embryo via the placenta and either causes death or impairs the differentiation of embryonic tissues, causing malformation. What is understood today under the congenital German measles syndrome is considerably more extensive and includes, in addition to malformation, growth retardation, premature birth as well as possible disease of organs or organ systems continuing well after the postnatal period. We were recently able to study a case of congenital encephalitis caused by the German measles virus and here too able to demonstrate histopathologically the persistence of the infection.

Brain↗
PubMed1979

[Psychosomal dwarfism with reversible growth hormone deficiency (author's transl)].

The diagnosis of psychosocial dwarfism in a 9 year-old boy with severe growth retardation (-6 1/2 standard deviations) was deduced from the typical history. The bone age was severely retarded and in the first days after admission a deficiency of growth hormone and other pituitary hormones was established. The change in environment per se led to a spontaneous reversal of the growth hormone deficiency within a short time. A rapid catch up growth was observed over the subsequent 2 1/2 years, as well as a normalisation of the psychological retardation.

Age Determination by Skeleton↗
PubMed1979

[Haemoglobin AIc (HbAIc) and juvenile-onset diabetes].

HbAIc was determined in 20 children with juvenile-onset diabetes and in 15 healthy control children of a similar age group. HbAIc was 10.2 +/- 1.6% (mean +/- SD) of the total haemoglobin in the diabetic patients and 6.3 +/- 0.5% (mean +/- SD) in the controls. This difference was significant (P less than 0.001). A linear correlation was found between HbAIc and mean glucosuria over a 6-week period prior to HbAIc determination (p less than 0.01). It is concluded that HbAIc determination might be an important indicator of diabetic control and of the response to therapeutic measures since it represents an integrated gauge of blood glucose concentrations over several weeks.

Adolescent↗
PubMed1979

[Oligosymptomatic manifestation of congenital hypothyroidism (author's transl)].

A 4-year-old girl with congenital dysgenesis of the thyroid gland is reported. The girl's appearance was that of hypothyroidism in childhood but the classical symptoms of constipation and cerebral retardation were missing. Thus it is assumed that relative insufficiency of the ectopic thyroid at the base of the tongue produced manifestations only a short time before diagnosis, having had no influence on cerebral maturity.

Age Factors↗
PubMed1979

[Polycystic disease of early infancy in two sisters (author's transl)].

Polycystic disease of early infancy is a heritable disorder diffusely involving both kidneys with no other evidence of renal parenchymal malformation. After discussing the typical histological data of two sisters with normal family history a short survey about classification and differential diagnosis of similar heritable renal cysts is given. With regard to the few other cases with familiar occurrence an autosomal recessive transmission is the most likely form of inheritance, delayed manifestation has not been observed until now.

Chromosome Aberrations↗
PubMed1979

[Hydrothorax during the neonatal period (author's transl)].

The congenital hydrothorax is a rare cause of the RDS in the newborn. Our observations on three patients with bilateral pleural effusions and 44 cases from the literature will be discussed; we emphasize the importance of this serious disease in the newborn period. The pathogenesis is largely unknown, however, its possible etiology like birth trauma or dysplasia of the lymphatic system are discussed. It should be pointed out that this condition can be rapidly recognized by radiographic examination and successfully treated. The reported survival rate is 29 out of 44 (66%).

Birth Injuries↗
PubMed1979

[Exaggerated somatomedin activity in the Beckwith-Wiedemann syndrome (author's transl)].

Beckwith and Wiedemann described the syndrome of exomphalos, macroglossia and gigantism with hypoglycemia and visceral organ hyperplasias. In some cases of severe hypoglycemias hyperplasia of beta cells of the pancreas was found. Hyperinsulinism, which has to date rarely been investigated, reacts strongly to beta cell stimulation and can hardly be suppressed. The cause of gigantism and organ hyperplasias is still unknown. After a short description of a case of hypoglycemias in the first two weeks of life a long-term profile of the endocrinologic abnormalities and carbohydrate metabolism is given. Growth hormone response to insulin is normal, tolbutamide is followed by severe hypoglycemias without an increase in the immunoreactive insulin levels; the activity of somatomedin is excessively increased. The high activity of somatomedin explains the high potency of growth in the different tissues and the hypoglycemic reactions and it seems reasonable to assume that somatomedin could create nesidioblastosis of the pancreas with hyperinsulinism and severe hypoglycemias. It is likely that the Beckwith-Wiedemann syndrome and the Laron type familial dwarfism with high plasma growth hormone, absent activity of somatomedin, and disorders in carbohydrate metabolism represent complementary diseases.

Abnormalities, Multiple↗
PubMed1979

[Pneumoperitoneum in a newborn without intestinal perforation (author's transl)].

This is the report of the rare complication of an isolated pneumoperitoneum in a premature infant of 28 weeks gestation with artificial ventilation due to severe RDS. This rare occurrence in immature babies with artificial ventilation should be considered in the differential diagnosis of abdominal emergencies in this age group. Etiology as well as therapeutic consequences will be discussed.

Humans↗
PubMed1979

[Intestinal obstruction following necrotizing enterocolitis (author's transl)].

The increase in survival from necrotizing enterocolitis results in an increased rate of late sequelae. We would like to take the opportunity to emphasize these new complications by a review of our patient material. 11 (23.9%) patients from a total number of 46 showed signs and symptoms of intestinal obstruction at different points in the course of the disease. In two surviving patients out of this group of 11, a resection of postinflammatory gut stenosis had to be performed within the first year. In the 9 children who died, particular emphasis is being paid in the autopsy reports to obstructive lesions in the gastrointestinal tract. Due to this rather frequent event (23.9%) of postinflammatory formation of strictures and stenoses in the recovery from NEC a functional radiographic study of the intestinal patency seems mandatory before discharge of any patient with NEC with operative or conservative treatment.

Enterocolitis, Pseudomembranous↗
PubMed1978

[Delivery of a normal child after chemotherapy of acute promyelocytic leukaemia during pregnancy (author's transl)].

Upon chemotherapy with daunorubidomycin and cytosinarabinoside, a patient suffering from acute promyelocytic leukaemia during the 28. week of pregnancy achieved complete haematological remission. In spite of complicating disseminated intravascular coagulopathy and aggressive chemotherapy a normal child was delivered by cesarian section during the 34. week of pregnancy. Specific problems in the treatment of acute leukaemia during pregnancy are discussed.

Cesarean Section↗
PubMed1978

[Ring chromosome 15 in a child (author's transl)].

A report is given of the occurrence of a ring chromosome 15 in a 5.6 year-old girl. The features of this case are mental retardation, small stature, microcephaly, malformation of the kidney, congenital heart disease and congenital dislocation of the hips. The features of this syndrome are very variable. Only 4 cases have been described up to 1975.

Child, Preschool↗
PubMed1978

Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions in normal children and in patients with various pathologic conditions.

Bayley-Pinneau, Roche-Wainer-Thissen, and Tanner height predictions at various chronologic ages were compared with final adult height in 56 normal subjects and in 34 patients with abnormal growth pattern (11 with familial tall stature, 7 with idiopathic precicious puberty, 6 with Turner syndrome, and 10 with primordial small stature or Silver-Russell syndrome). The two recent methods (Roche-Wainer-Thissen and Tanner) gave very accurate results and were superior to the Bayley-Pinneau method in normal subjects and in patients with familial tall stature. However, they overestimated adult height grossly in precocious puberty and moderately in Turner syndrome and in primordial small stature. It is concluded that calculations based on coefficients and regression equations obtained from normal children (as in the Roche-Wainer-Thissen and Tanner methods) can only be used in normal children or in patients with normal growth potential under adequate treatment. Calculations based on percentages of adult height (as in the Bayley-Pinneau method) are preferable in conditions in which the growth potential in relation to bone maturation is inherently reduced and cannot be corrected by treatment.

Adolescent↗
PubMed1978

[Duodenal ulcer in a newborn infant with gastro-intestinal hemorrhage (author's transl)].

A newborn infant was transferred to our hospital because of gastro-intestinal hemorrhage, starting a few hours after birth. Because of fetal distress a cesarean section had been necessary. The clinical examination as well as the results of the laboratory tests revealed nothing abnormal. In an upper gastro-intestinal X-ray series there was evidence for a duodenal ulcer. Under conservative treatment the baby recovered and has remained in a good condition without any bleeding episode until now. A repeat upper gastro-intestinal X-ray series was done at the age of 5 months and no evidence of ulceration could be found. The incidence and the reason of such an ulcer in the new born period is shortly discussed.

Duodenal Ulcer↗
PubMed1978

[Artificial ventilation of preterm and term infants (author's transl)].

One of the first aims of the neonatal care unit of the Paediatric Department of the University of Innsbruck (Austria) consists in taking care of dangerously ill children of Tyrol including the neighbouring federal states and the alpine part of Italy (South Tyrol). From SUMMER 1974 to the end of October 1976 1342 preterm and term infants were treated. 142 of these children died (mortality rate 10.5%). In 94 patients, i. e. 6.9% mechanical ventilation was necessary. 39 of these children, i. e. 41.5% survived. Two indications of artifical ventilation were predominant: Hyaline membrane syndrome in 59 children (survival rate 49%) and apnoe in 22 children (survival rate 27%). Electroencephalography was performed in 39 children during the neonatal period. 34 of these children were severely ill (gestational age of 24 to 37 weeks), 5 children were born at term nevertheless moribund. 18 of the 23 dead children of this group showed severe alterations in electroencephalography. The cause of death of 10 of these children was cerebral bleeding as verified by autopsy. 8 of the 16 surviving children showed a regular psychomotoric development, 5 children of this group had a normal electroencephalogram.

Apnea↗
PubMed1978

[Fosfomycin, a new antibiotic drug (author's transl)].

After i.v. injection of 25 mg/kh/BW and 50 mg/kg/BW to children age 5--6, no difference in the pharmakokinetic action can be found. The pattern of the plasma concentration allows the assumption of a 2 compartment model. There is a decrease of the plasma concentration in the steady state with a half life of 1,6 and 1,7 hours resp. The total volume of distribution is 30% of the body weight. Fosfomycin is eliminated by glomerular filtration only. The drug is not metabolished, as 98% and 95% of the dosage are recovered in active form in the urine. In premature and newborn babies there was a 1 compartment model assumed after i.v. administration of 25 mg/kg/BW. The distribution volumes with 41% of the body weight considerably greater then in older children. Elimination is again by glomerular filtration only. Plasma levels are decreasing considerably slower so that less of the drug is excreted in the 24-hour-urine. There is a sufficient penetration of the drug into the CSF. Bactericidal levels are reached within 48 hours by cumulation of the drug.

Age Factors↗
PubMed1978

[Bird-headed-dwarfism. A case report (author's transl)].

The case history and symptoms of a girl aged 12 months are reported suffering from bird-headed-dwarfism or Seckel-Syndrom: low birth weight in spite of prolonged pregnancy, typical "bird-headed-face", mikrocephaly, dwarfism, dystrophy, mental-motoric retardation.

Abnormalities, Multiple↗