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Biomedical subjects

H Frisch

Publications and source records attributed to H Frisch.

At least 127 records · Page 7Linked to original sources
PubMed1984

[Effect of intranasal administration of an LH-RH analog on basal gonadotropin concentrations and stimulation in patients with hypogonadotropic hypogonadism].

The effect of intranasal administration of the LHRH analogue D-Leu-6-des Gly-10 NH2EA on gonadotropin (Gn) stimulation was studied in 8 juvenile patients with ascertained hypogonadotropic hypogonadism, due to multiple pituitary deficiencies (MPD) in 5 cases and the Prader-Willi syndrome (PWS) in the remaining 3 patients. A bolus LHRH test was performed before and after a treatment period lasting between 2 and 5 weeks. In 2 MPD patients there was a transient rise in basal LH concentrations and a slight improvement in the second LHRH test; hence a hypothalamic lesion is assumed. In the other MPD patients there was no change in Gn stimulation. The sex steroid levels remained low. Gn stimulation was improved in all 3 patients with PWS after LHRH administration and in one 19-year-old boy the onset of puberty was probably induced by this therapy. However, after continuous administration of the analogue the initially increased Gn levels decreased again. In view of this inhibiting action on Gn levels the LHRH analogue does not appear suitable for the long-term treatment of hypogonadotropic hypogonadism.

Administration, Intranasal↗
PubMed1984

Beta-cell function recovery is not the only factor responsible for remission in type I diabetics: evaluation of C-peptide secretion in diabetic children after first metabolic recompensation and at partial remission phase.

In 9 newly diagnosed type I diabetic children the residual beta-cell secretory capacity was examined after stimulation with oral glucose load, glucagon and iv glucose plus arginine hydrochloride administration shortly after diagnosis and in the partial remission phase. A significant C-peptide secretion induced by these substances except by iv glucose was found at both investigation times. Whereas beta-cell function did only slightly increase from the initial testing to the measurements in the partial remission, beta-cell sensitivity increased significantly (p less than 0.05). The data suggest that "partial remission" referred to C-peptide secretion starts very early after insulin treatment and that other factors, possibly a decrease of peripheral insulin resistance, are involved in the improved metabolic control in partial remission phase.

Adolescent↗
PubMed1984

Diminished prolactin response to thyrotropin and insulin in anorexia nervosa.

Although patients with anorexia nervosa (AN) have a variety of endocrine disturbances, it generally is believed that the PRL response to stimulation is not altered in this disorder. We measured basal serum PRL values and serum PRL values after stimulation either with TRH (200 micrograms/m2) or with insulin (4 IU/m2) in 27 women with AN and 9 normal women. Basal values in anorexic women and normal women did not differ significantly, whereas all stimulation variables (mean PRL stimulation values, maximum PRL values, sum of increments, and area under the stimulation curve) were significantly lower in AN patients than in normal women. Furthermore, after TRH stimulation most of these variables correlated positively with the percentage of ideal body wt of the patients, indicating that the diminished PRL response was wt dependent. This diminished PRL response in the patients may accompany starvation and low estradiol values. Both conditions per se are known for their association with diminished PRL responses. Hence, no hypothesis which posits hypothalamic dopamine excess as the basic disturbance in AN seems justified. Moreover, diminished PRL responses in AN are not consistent with an assumption of hypothalamic dopamine depletion in this disorder.

Adolescent↗
PubMed1984

[Somatomedin activity in Wiedemann-Beckwith syndrome].

Two patients with Wiedemann-Beckwith-Syndrome and neonatal hypoglycemia are reported. The etiology for the impaired glucose metabolism has not been elucitated as yet. In some patients pancreatic islet-cell hyperplasia resulting in hyperinsulinemic hypoglycemia was suspected. Increased somatomedin activity was also proposed. We have measured somatomedin concentrations in both patients by bioassay and radioimmunoassay and found normal or slightly reduced plasma levels with both methods.

Asphyxia Neonatorum↗
PubMed1984

[Radiologic changes in metaphyseal chondrodystrophy of the McKusick type (cartilage-hair hypoplasia)].

A ten year old boy with parents of Rumanian and Turkish origin suffered from metaphyseal chondrodysplasia (McKusick type) with typical radiological changes of the metaphyseal endplates. Microscopic examination of his hair revealed only slight diminution of its thickness, and signs of increased brittleness. Because of Hirschsprung's disease resection of colon was performed. No immunologic changes were found.

Achondroplasia↗
PubMed1984

[EEG changes following perinatal asphyxia].

The EEG was studied in 46 pre-term and 43 full-term babies to evaluate its usefulness in estimating the degree of perinatal asphyxia. During the first 12 hours after a severe perinatal asphyxia isoelectric periods (IEP) of abnorm long duration are dominant in the EEG-records of pre-term and full-term babies and remain dominant in EEG-records of pre-term babies during the second 12 hour-period. During the first 12 hour-period in the EEG-records of full-term babies epileptic seizure patterns (ESP) appear sporadically, while in the second 12 hour-period they increase with respect to number and duration and often become even dominant within single records. During the second and third day of life ESP decrease in the EEG-records of full-term babies. IEP remain dominant in about 30% in the EEG-records of pre-term babies. During episodes of bradycardia with or without apnoea a three to fourfold increase of IEP is seen. Therefore an increase of number and/or duration of episodes of bradycardia does not seem to be without importance for cerebral function.

Age Factors↗
PubMed1984

[Incidence, laboratory diagnosis and serologic prediction of hemolytic disease of newborn infants due to ABO incompatibility].

The frequency of the haemolytic disease of the newborn due to ABO-incompatibility (ABO-HDN), requiring treatment, is with approximately 5% of all hyperbilirubinemias in newborns lower than usually expected. Contrary to common conception the serologic diagnosis of ABO-HDN by means of the direct antiglobulin test (DAT) is possible with satisfactory accuracy. The enormous laboratory burden of IgG-anti-A, -B testing during pregnancy is in poor conformity with clinically demonstrable illness. This discrepancy is due to the rarity of true ABO incompatibilities and not to the ineffectiveness of laboratory investigations.

ABO Blood-Group System↗
PubMed1984

[Sympodia--the caudal regression syndrome].

Description of a rare case of sympodia in a female newborn, first child of a seventeen year old mother. In addition to typical external deformities with malformations of the bones of the lower extremities, malformations of ribs and the vertebral column, there was also an agenesis of kidneys, ureters, bladder and urethra. The colon ended blindly in the pelvis minor, the anus was imperforate. There was a genital tubercle without urogenital opening.

Abnormalities, Multiple↗
PubMed1984

[The status of diabetic adolescents in search of apprenticeship].

Chronic diseases like diabetes may be a disadvantage in several professions. The aim of the study was to analyse the situation of juvenile diabetics searching for apprenticeship in Austria. 177 individuals (30 adolescent diabetics, 50 healthy adolescents of the same age and 97 masters) were asked by a special questionnaire about their opinions concerning employment and professional changes of juvenile diabetics. Following dimensions were tested: subjective knowledge about juvenile diabetes, objective knowledge about juvenile diabetes, physical capacity, psychological factors, life expectation, stay at home because of illness--admittance to hospital, diabetes--profession, exceptions necessary at work because of diabetes, attitude of the state towards the professional situation of the diabetics.

Adolescent↗
PubMed1984

[Pneumothorax as a cause of acute and recurrent neonatal hypoxia].

In 191 children suffering from RDS treated by mechanical ventilation or CPAP + PEEP according to the same protocol the incidence of pneumothorax was determined with 23% (44 infants). Mean birthweight and mean gestational age were lower in infants who developed pneumothorax. Pneumothorax occurred more frequently in children with bad pre- and perinatal history. Children who developed pneumothorax had received a lower fluid intake than those without. Incidence varied with severity of RDS and intensity of respiratory assistance. We tried to asses the duration and severity of hypoxia by means of transcutaneous pO2 measure and arterial blood gas analyses. As fast diagnosis and therapy helps to shorten the duration of hypoxia, we listened up the most frequent alternations of vital signs associated with pneumothorax. We found cyanosis, changes in heart rate and respiratory rate, arterial blood pressure and decrease of paO2. Hints to avoid a pneumothorax are given.

Humans↗
PubMed1984

[Follow-up study of children with hypoxia following pneumothorax].

A group of 23 children suffering from neonatal hypoxia (pO2 less than 50 mm Hg) due to pneumothorax was examined at an average age of 14 months. Evaluation at this early developmental stage was accomplished by combination of "Motoscopy", "Vojta's postural reactions" and the "Concept of provocation of normal behaviour under adverse conditions". Development of the group as a whole was found to be unexpectedly good: Two children with cerebral palsy, and seven with yet undefinable developmental course versus fourteen obviously normally developing children. Pneumothorax and drainage did not cause the frequent transient postural asymmetries in this group.

Age Factors↗
PubMed1983

[The L-DOPA-propranolol test for the evaluation of reserves in secretory growth hormone].

The growth hormone (GH) reserve of 75 short probands (age 1.9 to 23.8 years) was evaluated on the basis of oral L-dopa (300 mg/m2) and propranolol (0.75 mg/kg) administration. The GH response was normal in 21 probands (20.9 +/- 1.24 ng/ml; means +/- SEM) and was found to be higher than the response to the insulin or arginine test. 39 patients failed to respond (less than 6 ng/ml) and were diagnosed as GH deficient. In 15 cases an "intermediate" response (greater than 6 less than 12 ng/ml) was found and in these patients partial GH deficiency was assumed. There was not a single false positive result with this test, which cannot be said for any of the other commonly-used stimulation tests. In two children hypoglycaemic blood glucose levels were observed during the test, whilst in one case loss of consciousness and convulsions were seen. In four patients the test had to be interrupted because of side effects. These children had the following findings in common: GH deficiency was confirmed and the patients were still very young and basal blood glucose levels were relatively low at the beginning of the test. The L-dopa-propranolol test is an effective and reliable GH stimulation test, but severe side effects may occur.

Adolescent↗
PubMed1983

[Endocrine studies on the Prader-Labhart-Willi syndrome: puberty induction in a 19-year-old boy after long-term treatment with an LHRH analog].

In two girls (14 and 16 years) and one boy (19 years) with PLW-syndrome and pronounced obesity (240, 210 and 77% overweight) endocrine function tests were carried out. Growth hormone secretion was decreased but normalized after reduction of weight. Thyroxin levels as well as basal and TRH stimulated TSH concentrations were normal. HCG application in the boy induced no rise of the normal basal testosterone levels. Oral glucose tolerance test demonstrated an increased stimulation of insulin in two cases, no other symptoms of diabetes mellitus were found. In the LHRH test an insufficient rise of gonadotropins was found. However, after two weeks of pernasal application of an LHRH analogue (D-Leu6-des-Gly10-EA) the gonadotropin stimulation was distinctly improved and onset of puberty was induced in the male patient. These results are indicative of a hypothalamic disturbance in patients with PLW-syndrome.

Adolescent↗
PubMed1983

[Familial increase in thyroxine binding globulins in the blood].

Elevation of Thyroxine-binding globulin (TBG) in serum may lead to abnormally high total-thyroxine (T4) concentration. Causally hyper-TBG-aemia can either be acquired (estrogentherapy; hepatitis etc.) or familial. In a family-study with 3 generations 6 persons were found with this rare anomaly. Analysis of the pedigree is in accordance with an X-chromosomal transmission. Five of the affected family members were clinically euthyroid and had normal T4/TBG and effective thyroxine ratios (ETR). In one patient hypothyroidism was detected by these indirect parameters despite a normal T4-concentration. Changes in serum levels of thyroxine binding proteins make it difficult to diagnose a disturbance in thyroid function. However indirect parameters for free T4 (ETR, T4/TBG) as well as the TRH-Test allow a clear diagnosis in such patients.

Child↗
PubMed1983

Beta cell function in siblings of diabetic children and HLA type.

Beta cell function was tested in HLA-DR typed siblings of insulin dependent diabetic children. HLA identical siblings showed an increased insulin response compared with controls and HLA nonidentical siblings. This beta cell hyperactivity may be an early carbohydrate intolerance or a genetically determined increase in beta cell metabolism.

Adolescent↗
PubMed1983

[Elevated prolactin reserves in gonadal dysgenesis and agonadism].

Prolactin-reserve before and after TRH-stimulation was studied in 12 patients with gonadal dysgenesis and 2 children with agonadism. 7 patients (50%) had moderately increased basal PRL levels and 13 (93%) showed exaggerated PRL-responses to TRH at 30 min. The increased prolactin-reserve was independent of age and karyotype of our patients. Cause and significance of this observation remains to be clarified. It is speculated that elevated PRL-levels could be only a side-effect of hypergonadotropism in hypo- and agonadal subjects.

Adolescent↗