PubMed Health⌕ Search

Biomedical subjects

H Frisch

Publications and source records attributed to H Frisch.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Immunothrombocytopenia of the newborn caused by platelet-specific antibodies (anti-P1A1) (author's transl)].

For the first time in the German speaking area 8 cases of neonatal immunothrombocytopenia caused by platelet-specific P1A1 antibodies could be ascertained. The disease is caused by fetomaternal incompatibility against platelet antigens. All mothers were healthy. The children showed a postnatal tendency for petechial haemorrhages. Cerebral haemorrhages occurred in two cases. Optimal treatment consists of administration of P1A1-negative platelets (perhaps of the mother). Demonstration of platelet antibodies is possible nowadays by adequate serological methods.

Adult↗
PubMed1982

Gonadotropin responsiveness to luteinizing hormone releasing hormone in prepubertal and pubertal patients with growth hormone deficiency.

Gonadotropin response to 100 microgram/m2 LHRH was determined in 31 patients with growth hormone deficiency. According to their bone ages the patients were divided into a "prepubertal" (n = 18) and a "pubertal" (n = 13) group. The results were compared with the LHRH tests from 16 healthy prepubertal boys and girls and 32 healthy adult probands, respectively. The maximum increment of LH and FSH was evaluated. In the "prepubertal" group five patients had an insufficient rise of LH and FSH, four of them having additional anterior pituitary hormone deficiencies. In the "pubertal" group nine patients were found to be gonadotropin deficient, all of them had additional hormone deficiencies, TSH being the most frequently affected hormone. Only one of 14 gonadotropin-deficient patients had no other than growth hormone deficiency in addition. An isolated decreased FSH increment without LH deficiency was found in 6 male and 2 female patients and is not thought to be of diagnostic value. No influence of growth hormone treatment or growth velocity on the gonadotropin responsiveness was found. Patients with an additional thyreotropic defect could be classified as pituitary or hypothalamic disorder due to their reaction in the TRH test. These groups could not be differentiated by a single bolus LHRH test, indicating the need of prolonged stimulation to recover the pituitary hyporesponsiveness. Due to methodological problems the diagnosis of gonadotropin deficiency in an individual patient of the prepubertal age group might be questioned. However, a normal gonadotropin response to LHRH can be expected in prepubertal patients with growth hormone deficiency and may indicate a normal gonadotropin function.

Adolescent↗
PubMed1982

Prolactin and thyrotrophin response to thyrotrophin-releasing hormone in growth hormone deficiency.

Basal and thyroid-releasing hormone-stimulated (200 micrograms/m2) prolactin and thyroid-stimulating hormone (TSH) levels were measured in 31 patients with hypopituitarism (13 isolated growth-hormone deficiencies and 18 multiple pituitary hormone deficiencies). The results were compared with the prolactin response in 76 healthy prepubertal children. Normal prolactin concentrations were found in 13 patients whereas 11 had increased levels. TSH levels were either normal or increased in patients who were considered to have hypothalamic disorders. Decreased prolactin response was present in 7 children, 6 of whom had multiple pituitary deficiencies. Their TSH response was decreased as well, indicating pituitary failure. There was good overall correlation of peak prolactin with peak, TSH concentrations. Some patients with 'isolated' growth hormone deficiency had an abnormal prolactin response indicating an additional hormonal deficiency. All patients with low levels of serum thyroxine had abnormal prolactin or TSH levels, high in some, low in others. Two euthyroid patients with increased prolactin stimulation became hypothyroid during treatment with growth hormones, thus questioning whether prolactin is a more sensitive indicator of early thyroid insufficiency than thyroxine or TSH levels.

Adolescent↗
PubMed1981

[Hypothalamic endocrinopathy in histiocytosis X (author's transl)].

Histiocytosis X in a 2-year-old boy with mainly skull manifestations was treated with radiotherapy and cytostatic drugs. Diabetes insipidus and growth retardation followed. Secretory capacity of GH was variable, periods of normal and insufficient secretion alternating during the 15-year observation period; there was a satisfactory response to GH therapy for one year. Thyrotropin and ACTH deficiency were diagnosed 3 1/2, and again 9 years after termination of histiocytosis therapy. Since there was no relapse of histiocytosis, this hypothalamic endocrinopathy is interpreted as being a late sequela of radiotherapy.

Adolescent↗
PubMed1981

Pulsatile secretion of gonadotropins in early infancy.

In adults, luteinizing hormone (LH) and follicle stimulating hormone (FSH) are secreted in a pulsatile manner. Prior to puberty gonadotropin (GN) levels are low and show only small fluctuations. The following investigation was performed to elucidate the type of GN secretion in infants. LH and FSH were determined every 30 min over a period of 8 h in three different groups: Group 1:2 male and 2 female adults; Groups 2:2 male and 2 female prepubertal children; Group 3:3 male and 3 female infants, aged 6-12 weeks. Group 1 showed a clear pulsatile secretion of LH (4.5-23.5 mIU/ml [range]) and FSH (6.9-16.0 mIU/ml). Group 2 demonstrated a rather constant secretion of LH (less than 1.5-2.3 mIU/ml) and FSH (1.6-4.9 mIU/ml). Group 3: In male infants pulsatile secretion of LH (3.6-34.7 mIU/ml)--and to a lesser degree of FSH (1.8-4.6 mIU/ml)--were found. In female infants the pulsatile secretion of FSH (6.5-22.7 mIU/ml) was more pronounced than that of LH (less than 1.5-4.7 mIU/ml). The secretory pattern in early infancy is of a pulsatile type.

Adult↗
PubMed1981

Circadian patterns of plasma cortisol, 17-hydroxyprogesterone, and testosterone in congenital adrenal hyperplasia.

In 11 children aged between 2 and 17 years with (nonsalt-losing) congenital adrenal hyperplasia (21-hydroxylase deficiency) blood was drawn at 90-minute intervals during a 24-hour period and levels of 17-hydroxyprogesterone, testosterone, and cortisol were measured. Levels of 17-ketosteroids and pregnanetriol were measured too in 24-hour urine samples. These measurements were taken under different regimens of treatment and after interruption of treatment. Cortisol level rose and fell rapidly after administered corticosteroid, and reached unphysiologically high levels. Testosterone levels showed pronounced variations but stayed in the normal range for most of the time even in untreated patients; thus testosterone provides a poor control parameter. Levels of 17-hydroxyprogesterone showed extreme fluctuations and very high peak levels in untreated patients; standard treatment with two or three daily doses of corticosteroids did not prevent a pronounced rise in its level after midnight. After the first morning dose of hydrocortisone a very steep fall was observed. The 24-hour pregnanetriol excretion correlated well with the corresponding total integrated 17-hydroxyprogesterone area. It is concluded that single 17-hydroxyprogesterone values are unlikely to give adequate information about the quality of treatment.

17-Ketosteroids↗
PubMed1981

[Subclinical hypothyroidism in infancy (author's transl)].

Clinical symptoms of hypothyroidism (constipation, macroglossia, umbilical hernia, typical face hyperbilirubinaemia) were found in a 4 months old infant. Body height and activity were normal and the skin did not show the typical dryness. Total-thyroxin (T4) level was normal as well as basal thyrotropin (TSH), only after stimulation with thyrotropin releasing hormone (TRH) an exaggerated response was observed. These hormonal findings are typical for subclinical hypothyroidism, a well known disturbance in adults. The clinical as well as therapeutic considerations are discussed in this patient.

Child, Preschool↗
PubMed1981

[Local manifestations of neonatal group B streptococcal disease (author's transl)].

In the case of neonatal group B streptococcal disease, two distinct types of illness have been described in the past few years. The early onset type occurs in the first hours of days of life and emerges as septicemia. The late onset type occurs after the first week and emerges as meningitis. Other frequent local manifestations are pneumonia and pleural effusions, but there are few reports on localized inflammation of other organs. This paper gives a brief survey of the local manifestations of the disease. In addition, a case of a 1120 g premature of 29 gestational week is reported. After ten uneventful weeks, the patient developed acute fulminating group B streptococcal septicemia. The initial signs of apnea, respiratory insufficiency and shock were followed by meningitis, cellulitis of the tongue and skin and severe coagulopathy. After seven days the baby died of an intracranial hemorrhage.

Female↗
PubMed1981

[Summer camping for juvenile diabetics: effects on psychological variables (author's transl)].

The course of diabetes mellitus does not only depend on mere medical treatment. Psychological factors also play an important part. Since 1955 summer camping for diabetic children has been organized in Austria enabling juvenile diabetics to live together with a group of children sharing the same fate. This community offers the opportunity for experience to be interchanged and for knowledge about diabetes to be increased. The children's self confidence and independence is improved. In this study the changes of psychological variables during a 4 week camping period are documented. 49 children between the ages of 8-14 years were tested by a special questionnaire which registered 4 dimensions: social behavior, independency, the attitude of the children to their disease and the knowledge about it. At the end of the camping period a significant improvement in the 4 variables was found when compared to the beginning of the course. These results indicate that the institution of a diabetic camp is very important for the psychological and personal development of juvenile diabetics.

Adolescent↗
PubMed1980

Glycosylated hemoglobin (HbAtc) and plasma lipoproteins in juvenile onset diabetes mellitus.

Plasma lipid and lipoprotein levels and hemoglobin Atc estimates of diabetic control were measured in 19 juvenile-onset diabetics (8 girls and 11 boys) upon admission (day 1) and at the end (day 25) of a 4-week summer camp, where the patients were put on a controlled diet with a daily linoleic acid intake of about 16g. Lipoproteins were also measured in 64 healthy controls. When values on day 25 were compared with those of day one, a slight but significant decrease in mean hemoglobin Atc (10.4 +/- 0.3 vs. 9.8 +/- 0.4% of total Hb; M +/- S.E.M.; p < 0.05) was noted, as well as in increase in mean high density lipoprotein cholesterol (1.0 +/- 0.07 vs. 1.3 +/- 0.1 mmol/l; M +/- S.E.M.; p < 0.02) and a decrease in mean triglycerides (1.2 +/- 0.1 vs. 0.7 +/- 0.04 mmol/l; M +/- S.E.M.; p < 0.001). A linear correlation was found between hemoglobin AIc on day 25 and urine glucose excretion during the camping period (p < 0.01). However, no relationship was noted between hemoglobin AIc and either lipids or lipoproteins. Other factors, e.g. the controlled intake of saturated fat or physical activity could have responsible for the changes in triglycerides and high-density lipoprotein cholesterol levels noted by the end of the camp.

Child↗
PubMed1980

[Septo-optic dysplasia and growth hormone deficiency. De Morsier-syndrome (author's transl)].

In a 4 1/2 year old blind boy with cryptorchidism and severe growth retardation a deficiency of growth hormone was verified. He has the symptoms of septo-optic dysplasia, an inborn malformation of the brain with hypoplasia of the optic nerves and tractus opticus, absent septum pellucidum and variable pituitary hormone deficiencies. Treatment with growth hormone was successful. In children with growth hormone deficiency the syndrome seems to be not infrequent.

Abnormalities, Multiple↗
PubMed1980

[beta-Cell residual function in juvenile diabetes mellitus (author's transl)].

Estimation of C-peptide (IRCP) can be used to measure the residual beta-cell function in insulin treated diabetics. IRCP was estimated in 46 juvenile diabetics. A significant correlation between basal IRCP-levels and duration of diabetes as well as daily insulin requirement could be shown. There was no linear correlation between glucosuria and IRCP. However, patients with IRCP > 1,0 ng/ml had significantly lower glucosuria ( p < 0,005). Endogenous residual function of the beta-cells seems to be of importance for metabolic control in diabetic children.

Adolescent↗
PubMed1980

[Diagnosis of retinal vascular changes in diabetic children by means of fluorescein-angiography (author's transl)].

By means of fluorescein-angiography diabetic microangiopathy can be earlier revealed than by means of ophthalmoscopy. 36 children with diabetes (aged 6,25-15,5 years, x 11,6 years) with a duration of the diabetes between 0 and 12,75 years (x 3,9) were submitted to fluorescein - angiography, in 20 cases a follow up study was performed. Pathological changes were found in 21 cases, in 10 of 15 children with normal angiograms the duration of the disease was less than 5 years. More than 50% of all patients followed up showed an increase of diabetic microangiopathy.

Adolescent↗