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H G Frohmüller

Publications and source records attributed to H G Frohmüller.

43 records · Page 3Linked to original sources
PubMed1984

Monoclonal antibody-based radioimmunoassay compared with conventional enzyme immunoassay in the detection of prostatic acid phosphatase.

Determination of serum prostatic acid phosphatase by a monoclonal antibody-based radioimmunoassay (RIA) was compared to a polyclonal antibody-based enzyme immunoassay (EIA) to study the clinical value of both test systems. The 97.5 percentile of 48 patients with histologically proven benign prostatic hyperplasia (BPH) was chosen as the normal range. The classification of 38 patients with prostatic carcinoma (CaP) stage pT1-3N0-3M0 was performed by radical prostatectomy and/or pelvic lymph node dissection. Elevated prostatic acid phosphatase (PAP) serum concentrations were observed in 1 of 26 patients with CaP stage pT1-3N0M0 by the EIA and in 7 of 12 patients with CaP stage pT1-3N1-3M0 in both assays. Distant metastases observed in 15 patients lead to elevated PAP serum concentrations in 12 patients by the RIA and in 13 patients by the EIA. The correlation coefficient of both test systems was 0.97. These data indicate that the determination of PAP by a monoclonal antibody-based RIA is of no advantage compared to polyclonal antibody-based EIA, though both test systems are suitable for the follow-up of patients with CaP. Early recognition of CaP, however, is not possible by these two test systems. Elevated serum concentrations of PAP in both assays indicated metastatic disease. These findings should be considered if a curative treatment of CaP is planned.

Acid Phosphatase↗
PubMed1981

Electrohydraulic lithotripsy with aspiration of the fragments under vision--304 consecutive cases.

We herein report on 304 consecutive cases of bladder stones treated by electrohydraulic lithotripsy. The special armamentarium is described. The average age for male patients was 68.5 years, the oldest being 102 years, and for female patients it was 63.9 years. Of the patients 38.5 per cent were high risk. The weight of the transurethrally removed stones ranged from 1 to 135 gm. In 70.4 per cent of the male patients transurethral resection of the prostate was done under the same anesthesia and technical problems were encountered in 12 operations (4 per cent). Bladder perforations occurred in 5 patients but cystotomy and drainage were necessary in only 1 (0.3 per cent).

Adolescent↗
PubMed1980

The value of perineal punch biopsy in estimating the histological grade of carcinoma of the prostate.

The degree of accuracy of the histological grade of carcinoma of the prostate obtained by perineal punch biopsy was analyzed by comparing the histological findings with those of radical prostatectomy specimens. Biopsy specimens of 97 of 100 patients who underwent radical prostatectomy between 1969 and 1979 were reevaluated. In 43% of the cases, perineal punch biopsy revealed a uniform architectural pattern, which was classified as well-differentiated adenocarcinoma in 21 cases and poorly differentiated adenocarcinoma in 22 cases. However, of the 21 cases determined by biopsy to be uniformly well-differentiated adenocarcinomas, only seven (33.3%) were confirmed by evaluation of the radical prostatectomy specimens. A uniform, poorly differentiated adenocarcinoma was ultimately found in only five operative specimens of the 22 patients with this preoperative diagnosis. As one case clearly demonstrated, multifocal origin of carcinoma of the prostate is the main source of the frequently occurring error encountered with perineal punch biopsy in determining the grade of differentiation.

Adenocarcinoma↗
PubMed1979

Transurethral laser urethrotomy in man: preliminary report.

After in vitro and in vivo endoscopic laser investigation on normal and experimentally strictured urethras in dogs transurethral laser urethrotomy was done on men. A neodymium: yttrium aluminum garnet laser with a flexible laser light guide was used. The endoscope developed for this purpose is described in detail. The first laser operations were without complications.

Adult↗
PubMed1979

Laser investigations of the strictured dog urethra.

The effects of the Neodymium:YAG laser beam on normal as well as on granulation tissue of the dog urethra were investigated in vitro. To determine the effectiveness of the laser beam special attention was paid to the size of the local spot and the pulse duration. After determination of the most favorable diameter of the focus and the pulse duration of the laser beam, endoscopic laser examinations were performed on normal and experimentally strictured urethrae in dogs. A suitable laser endoscope was designed and a surgical technique for laser-beam treatment of the strictured urethra was developed. The postoperative follow-up period was up to 6 weeks. There was no need for postoperative urinary diversion. Neither bleeding nor perforations were observed.

Animals↗
PubMed1976

An improved cold punch resectoscope.

The introduction of an improved cold punch resectoscope is reported. The advantages of cold punch resection of the prostate over electroresection are described. Improvements of other direct vision urethro-cystoscopes are mentioned.

Cystoscopes↗