Biomedical subjects

H G Scheil

Publications and source records attributed to H G Scheil.

At least 19 recordsLinked to original sources

PubMed2006

Blood group and serum protein polymorphisms in a population group of Moldavians.

The distribution of the alleles and haplotypes for blood groups A1A2B0, MNSs, RHESUS, P1, KELL-CELLANO and biochemical markers of the alleles of loci AMY2, HPA, GC, C3, TF, BF, CP, PI (including subtypes) were studied in 125 Moldavian individuals from Karahasani settlement, Stefan-Voda District, Republic of Moldavia. The results show that the gene pool of Moldavians is similar to those of Southeastern European populations.

Blood Group Antigens↗

PubMed2005

Haemogenetic studies in Bulgaria.

Within a study of the genetics of Bulgarian populations, the markers AB0, RH, MNS, P, HPA, GM(1), PGM1, ACP and ESD were examined in 2346 individuals from seven subpopulations of south-central and south-eastern Bulgaria. The combined data have been compared with other populations of the Balkans.

Blood Group Antigens↗

PubMed2005

Dermatoglyphic studies in eastern and south-eastern Europe.

In nine population samples from Bulgaria, Croatia, Greece, Hungary, Republic of Macedonia (Skopje and Aromuns from Stip region), Romania, Serbia and Slovakia 12 dermatoglyphic variables have been studied. There are distinct differences between the populations and between males and females. The Macedonian Aromuns are clearly separated from the other populations.

Dermatoglyphics↗

PubMed2004

Allele frequencies of D21S11, FGA, TH01, and VWA in populations of the Balkans.

This study is part of an extensive investigation of the genetic relationship between Balkan populations, especially the Aromuns. Allele frequencies of four STRs (D21S11, FGA, TH01, VWA) from Macedonians (Skopje), Gramostian Aromuns from the Stip region (Macedonia), Moskopolian Aromuns from Krusevo (Macedonia), and Musequiar Aromuns from Dukasi (Albania) are presented.

Albania↗

PubMed2004

Phenotype and allele frequencies of some serum protein polymorphisms in populations of the Balkans.

Within a study of the genetics of Southeastern European populations seven serum protein polymorphisms (AMY2, BF, C3, CP, GC, HPA, TF) were examined in two samples of Aromuns and one reference sample (Musequiar-Aromuns from Dukasi in Albania, Moskopolian-Aromuns from Krusevo, Republic of Macedonia, and Macedonians from Skopje). The neighbor joining tree as well as the principal component analysis show results which do not correspond well to the geographic and historic background. This indicates that in the present case the serum protein polymorphisms give no clearly defined information about the relationships between the Balkan populations and to the origin of Aromuns.

Albania↗

PubMed2003

[Rugen (Germany): hemogenetic study of an island population].

24 haemogenetic markers (5 erythrocyte antigens, 7 polymorphisms of serum proteins. 12 polymorphisms of red cell enzymes) had been studied in up to 171 individuals from the island of Rügen (Germany, Baltic Sea). The cluster analysis separates clearly the ügen sample just as the islands of Hiddensee and Ummanz from the neighbouring populations. The comparison of the data with neighboured larger populations as for instance Denmark, Hamburg or Sweden clearly results in an exceptional position of the island of Rügen. The possible reasons are discussed.

Alleles↗

PubMed2003

Blood group frequencies in Romania: microregional and ethnic differences.

This study is based on the results of the blood group typing (AB0, MN, RH: D/d) of two samples from Romania and on literature data. The 40 population samples used are scattered on the today's territory of Romania. Some data refer to more or less endogamous villages or groups of villages which belong to the same marriage area, some data refer to towns with admixed populations. Samples of nine ethnic minorities have been included in the study. The results have been discussed on the basis of the historical and geographical background.

ABO Blood-Group System↗

PubMed2002

Allele frequencies of alpha-1-antitrypsin (PI) in the Balkans.

The phenotype and allele frequencies of alpha-1-antitrypsin has been studied by an IEF technique (pH 4.2-4.9) in ten population samples from the Balkans. The allele frequencies varied from 0.6667 to 0.7361 (*M1), 0.1100 to 0.1793 (*M2), 0.0992 to 0.1700 (*M3), 0 to 0.0105 (*S), 0 to 0.0078 (*Z) and 0 to 0.0172 (others). The results were compared with data from South and Middle European populations from the literature. Most of the populations form a cluster with small genetic distances, and a weak relationship to geographical distributions. In contrast, the samples from Southern France, the Iberian Peninsula and Madeira form a clearly separated cluster. The differences are mainly based on high frequencies of PI*S in the latter populations.

Albania↗

PubMed2001

[Helgoland (Germany): hemogenetic study of an island population].

24 haemogenetic markers (5 erythrocyte antigenes, 6 polymorphisms of serum proteins, 12 polymorphisms of red cell enzymes) had been studied in up to 80 individuals from the island of Helgoland (Germany). The cluster analysis separates clearly the Helgoland sample from the neighbouring populations as well as from European standard data. This special position is interpreted partly by genetic peculiarities developed in the course of time, partly as a consequence of genetic drift.

Adult↗

PubMed2001

Population genetic studies in the Balkans. I. Serum proteins.

Within a study of the genetics of Southeastern European populations seven serum protein polymorphisms (AMY2, BF, C3, CP, GC, HPA, TF) were examined in three samples of Aromuns (Albania: the village of Andon Poci, province Gjirocaster, Republic of Macedonia: Stip region, Romania: the village Kogalniceanu, province Dobruja) and four reference samples (Albanians: Tirana, Romanians: Constanta and Ploiesti as well as Greeks (Northeastern Greece)). The Aromun samples from Albania and Romania form one separate cluster and the reference samples together with the Aromuns from Macedonia (Stip region) form a second one.

Albania↗

PubMed2001

Population genetic studies in the Balkans. II. DNA-STR-systems.

Within a study of the genetics of Southeastern European populations four DNA-STR-systems (D21S11, FGA, TH01, VWA) were examined in seven samples (samples of three Aromuns and four other Balkan populations). The results have been compared to data from four samples from literature (Austrians, Germans, Hungarians, Slovenians). The results show three clusters: a) the Aromuns from Albania (Andon Poci) and Macedonia (Stip region), b) the Romanian Aromuns (Kogalniceanu), Romanians (Constanta, Ploiesti) and Albanians (Tirana) und c) the data from literature. A sample of Northeastern Greece clearly differs from these three clusters. Including seven serum protein polymorphisms (without the populations from literature) results in two clusters: a) the three Aromun populations and b) Albanians and Romanians. Again the sample of Northeastern Greece clearly differs from these clusters.

Albania↗

PubMed2001

[Variability of blood group frequencies in Romania].

This paper presents the results of a study of two population samples from Dobruja and Muntenia (Romania) as well as data from the literature (AB0, MN, Rhesus (D/d) and HPA). The data have been pooled according to the different regions of Romania. Interestingly, the Carpathian Mountains do not form a genetical barrier: there are clear genetical similarities between the provinces east and west as well as between the provinces south and north from the mountains. The differences and similarities between Romania as a whole and other populations in this region reflect the historical processes of the last centuries.

Alleles↗

PubMed2001

[Genetic studies in the Cologne administrative district (North Rhine-Westphalia, Germany): DNA-STR systems FGA, TH01, VWA and YNZ22].

The DNA-STR systems FGA, TH01, VWA, YNZ22 have been studied in two German population samples (Eschweiler, Stolberg and Hürtgenwald, Inden, Langerwehe, administrative area of Cologne, Northrhine-Westphalia). The cluster analysis, including data from Düsseldorf, Germany and from Poland, resulted in a cluster with Eschweiler, Stolberg and Düsseldorf, separating to a certain degree Hürtgenwald, Inden, Langerwehe and Poland more clearly. In contrary to the expectations (based on the history of the migration from Northeastern Europe to Northrhine-Westfalia) and the results of the study of 22 hemogenetic systems (Scheil & Huckenbeck 2000) there was a somewhat larger genetic distance between Eschweiler, Stolberg and Poland than between Hürtgenwald, Inden, Langerwehe and Poland. The combined data of the four STRs and the 22 hemogenetic systems resulted--as expected--in smaller genetic distances between Eschweiler, Stolberg and Poland as well as between Düsseldorf and Poland. These different genetic distances are interpreted as a result of the migration from North-East Europe to North Rhine-Westphalia in the last 130 years and the selective geographic distribution of the migrants in the industrial and urbanised areas.

Alleles↗

PubMed2001

[DNA PCR typing of non-human primates].

Human beings and non human primates show similarities in the non coding DNA range too, but up to now there are only a few data. This paper presents first results of a study dealing with a larger spectrum of species and individuals, considering the genetic marker HLA-DQA1, LDLR, GYPA, HBGG, D7S8, GC (partionally coding) and VWA, FES, F13B, TH01, CD4, FGA (not coding). The results show that not only the apes can be typed but also Macaca sylvanus as a member of the Cercopithecoidea. In contrast to earlier publications there is an unexpected larger similarity between the allele ranges of the apes studied and those of human beings.

Animals↗

PubMed2000

[Hemogenetic studies of the Cologne political district (North Rhine-Westphalia, Germany)].

In two population samples from the administrative area of Cologne, North Rhine-Westphalia, Germany (Eschweiler/Stolberg, B frequencies > 0.0800; Hürtgenwald/Inden/Langerwehe, B frequencies < 0.0800), 26 hemogenetic systems had been studied. The resulting differences of allele and haplotype frequencies, resp., are significant. These differences are interpreted as a result of the migration from North-East Europe to North Rhine-Westphalia in the last 120 years and the selective geographic distribution of the migrants in the industrial and urbanized areas.

ABO Blood-Group System↗

PubMed2000

DNA-PCR systems TH01 and VWA31: population data from Albania and Romania.

The microsatellite systems TH01 and VWA31 have been typed and analyzed for three populations from Albania (city population of Tirana, and Aromuns from a small-sized village, named Andon Poci, near Gjirokaster) and Romania (city population of Constanta). The genetic data have been compared with other, particularly South-Eastern European population.

Albania↗

PubMed2000

How many markers or how many alleles per system are appropriate in zygosity testing?

Due to the development in DNA-PCR-technique more and more systems with a high number of alleles have been established in twin diagnosis. Because of their high effectiveness in resolving of genetic questions it is not amazing that some authors have postulated the thesis that typing of 5 to 10 DNA-PCR systems can prove monozygosity. For this paper the use of different systems (conventional and PCR systems) has been tested for twin diagnosis and the observed effects are discussed.

Alleles↗

PubMed1999

DNA-PCR system FGA (FIBRA)--genotype and allele frequencies in a sample of western Germany (Düsseldorf region).

Frequency data for the STR system FGA (HumFibra) were obtained from a Caucasoid German population sample (Düsseldorf area) of 424 unrelated individuals. PCR products were detected by horizontal polyacrylamid gel electrophoresis and a total of 16 alleles was identified by side-by-side comparison with a commercially available sequenced ladder. The observed genotype distribution showed no significant deviation from the Hardy-Weinberg equilibrium. The high information content (pooled German data: rate of heterozygosity = 0.8626; probability of match = 0.0344; mean exclusion chance = 0.7240) render this system a useful tool not only in forensic casework (criminal and paternity cases) but in population genetics too.

DNA↗