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Biomedical subjects

H Günther

Publications and source records attributed to H Günther.

At least 73 records · Page 4Linked to original sources
PubMed1984

[NMR in the 80s: new nuclei, new pulses].

In recent years, nuclear magnetic resonance spectroscopy has been enriched by a large number of new experimental techniques which, on the one hand, have opened up new areas of applications in physiological chemistry and even medicine, and on the other hand resulted in considerable progress for nmr spectroscopy as a branch of molecular spectroscopy as a branch of molecular spectroscopy as it is used in chemistry. In this context, two aspects must be emphasized: The nmr spectroscopy of rare nuclei and the invention of two-dimensional methods. Both aspects will be treated using selected examples: nmr measurements for iron-57, chromium-53, and nitrogen-15 as well as new experimental techniques like polarization transfer, J-resolved two-dimensional nmr spectra, two-dimensional shift correlations and multiquantum phenomena are discussed. Besides practical applications the basic physical principles of these techniques are briefly evaluated.

Chemical Phenomena↗
PubMed1984

[Prenatal diagnosis of fetal meconium peritonitis, therapy and clinical course. With a contribution to the differential diagnosis of fetal ascites].

We report on the prenatal diagnosis of a case of foetal meconium peritonitis pursuant to colon perforation in the 34th week of gestation. A sonographic examination of the foetus showed ascites, dense zones around the peritoneum and intestine, hepatosplenomegaly and hydroceles, as well as a slight hydramnios. The foetal abdomen was punctured under ultrasonographic control, and ascitic fluid was withdrawn. It was sterile but included granulocytes, leucocytes, epidermal epithelial cells and lanugo hairs, thereby confirming the diagnosis. The bilirubin concentration was very high, and the protein content was also increased. An amniofoetography gave a clear picture of the small intestine and showed a calcified zone in the upper left abdomen. A Caesarean section was performed prior to term, and the prenatal diagnosis was confirmed. After surgical correction the infant has developed satisfactorily up to the present age of 15 months, even though mucoviscidosis was diagnosed at the age of 5 months. In addition to ascites due to meconium peritonitis, several other types of foetal ascites are discussed.

Adult↗
PubMed1984

[Visual and phonological access to the mental lexicon].

In a lexical decision experiment we investigated whether the mental lexicon is accessed directly by a visual code or by phonological mediation. Subjects were asked to make lexical decisions where phonological coding was either beneficial or detrimental. It was found that subjects used phonological coding when it was helpful and abandoned this strategy when it was a hindrance. These results support the hypothesis that lexical decisions can be based on variable coding operations. The fact that subjects were faster in classifying words when they did not rely on phonological codes is consistent with the assumption of faster visual access to the mental lexicon. Taken as a whole, these results are consistent with models which assume phonological coding to take place after lexical access as well as with models postulating parallel access to the mental lexicon. They are not compatible with models postulating mandatory prelexical phonological coding.

Decision Making↗
PubMed1983

Spectral analysis of tremorine and cold tremor electromyograms in animal species of different size.

In 14 mice (36.2 +/- 5.4 g), 17 rats (425 +/- 46.4 g), and 11 rabbits (3,200 +/- 340 g) a comparative electromyographic analysis of tremorine tremor and cold tremor was performed in gastrocnemius and tibialis anterior muscles using spectral analysis. The mean frequency of cold tremor decreased with increasing body weight (mice: 40.2 +/- 4.5 Hz; rats: 31.3 +/- 4.9 Hz; rabbits: 16.4 +/- 3.2 Hz). With tremorine tremor no such allometric correlation was found for tremor frequency and body weight (mice: 17.7 +/- 3.6 Hz; rats: 19.6 +/- 5.1 Hz; rabbits: 15.9 +/- 2.1 Hz). Cross spectral analysis revealed that during cold tremor the flexor muscle (tibialis anterior) and the extensor muscle (gastrocnemius) of rabbits are activated alternately. The mean phase shift between the activation of flexor and extensor muscle was -155.5 degrees. Stronger activation was observed in the flexor muscle. Tremorine tremor was characterized by synchronous activation of flexor and extensor muscles with a mean phase angle of 3.0 degrees and a predominance of the extensor muscle. The results suggest that the nervous mechanisms for the generation of tremorine tremor and cold tremor are different.

Animals↗
PubMed1983

Laryngo-tracheo-oesophageal cleft. Clinical features, diagnosis and therapy.

The laryngo-tracheo-oesophageal cleft is marked by a missing anatomical separation of the oesophagus and the larynx. The cleft can be restricted to the dorsal part of the larynx (type I), extend to the upper area of the trachea (type II) or involve the whole of the trachea (type III). In reviewing our three cases and 82 cases in the literature, clinical features, diagnosis, and therapy of this rare condition are presented. The condition leads almost always to life-threatening disturbances in the form of asphyxia and aspiration pneumonia. The diagnosis is made through direct laryngoscopy. Radiological demonstration of swallowing and tracheo-oesophagoscopy are necessary additional investigations. In many cases further severe malformations of organs are found, i.e., oesophageal atresia and tracheo-oesophageal fistulae. Despite early detection the prognosis remains unfavourable with a mortality of 46%. With few exceptions, an early operative correction of the defect is required. Access to the dorsal laryngeal area is achieved usually by a lateral pharyngotomy. Difficulties arise in securing adequate closure of the dorsal larynx, because of lack of sufficient tissue material. Despite secure closure of the laryngo-tracheo-oesophageal cleft, disturbances of swallowing often persist. Development of speech is not impaired.

Asphyxia↗