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Biomedical subjects

H Günther

Publications and source records attributed to H Günther.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Local application of prostaglandin F2 alpha to primigravid interruption patients in first trimester].

A comparison was made between three methods of local prostaglandin F2 alpha application for medicamentous induction of interruption in 375 primigravidae in the first trimester. They were extra-amniotic transcervical application, intracervical instillation of gel, and intracervical application, using a portio adaptor according to Fikentscher/Semm. Retrospective and prospective analyses were made of 125 unselected patients for each of the three methods, and the portio adaptor technique proved to be most effective of all with regard to non-invasive cervix dilatation. This method, when compared to others, was found to be best acceptable to patients and medical personnel alike, with no risk of subsequent ascending infection and with lowest prostaglandin consumption.

Abortion, Spontaneous↗
PubMed1982

[An unusual form of craniofacial dysmorphism with mechanical respiratory disturbances in newborns (author's transl)].

Gross and histologic findings at autopsy of a one week old newborn baby with respiratory distress and mechanical obstacles to adequate intubation revealed a variation of the craniofacial dysmorphy syndrome: hypoplasia of the mandible combined with dysplastic and hypoplastic tongue and complete situs inversus. The tongue consisted of an hypoplastic smooth anterior part and a hypertrophic posterior part with the usual papillae. Both parts were separated by a deep sulcus across the middle of the tongue with a predominantly fibrous amuscular bottom. Because of this anomaly the posterior part of the tongue was retracted covering the orifice of the larynx and thus causing the respiratory distress. The lesion is discussed in context with data of similar syndromes.

Autopsy↗
PubMed1981

2-n-nonyl-4-hydroxy[3-3H]quinoline N-oxide: interaction with the mitochondrial membrane.

1. Synthesized 2-n-nonyl-4-hydroxy[3-3H]quinoline N-oxide ([3H]NoHOQnO) is a powerful inhibitor of both NADH oxidase and succinate oxidase activities in submitochondrial particles from beef heart. 2. The binding of [3H]NoHOQnO to submitochondrial particles reveals one specific binding site, which is sensitive to antimycin, and a large amount of aspecific binding. 3. The content of [3H]NoHOQnO-specific binding sites is related to the cytochrome b content in the particles. 4. The binding of [3H]NoHOQnO to the specific site causes the inhibition of electron transfer. 5. The relation between the inhibition of NADH oxidation and [3H]NoHOQnO-specific binding is hyperbolic.

Animals↗
PubMed1981

[Further characterization of lipopolysaccharides from Pasteurella multocida].

The biological properties, sedimentation behaviour, and electron-optically visualised structures of lipopolysaccharides from Pasteurella multocida were found to be identical with lipopolysaccharides from Enterobacteriaceae. Hard evidence to the effect that lipopolysaccharides from Pasteurella multocida are R-lipopolysaccharides were produced by the composition of monosaccharides together with experiments on the basis of disc electrophoresis.

Animals↗
PubMed1980

Utilization of (E)-2-butenoate (crotonate) by Clostridium kluyveri and some other Clostridium species.

Clostridium La 1 obtained from a Clostridium kluyveri culture was compared with a typical C. kluyvery strain (DSM 555). The former grows on cortonate and is unable to use ethanol-acetate as carbon sources. The latter grows on crotonate only after long adaptation periods. Resting cells of both strains show also pronounced differences in the fermentation of crotonate. This holds even for C. kluyveri grown on crotonate. Besides several other differences the most striking is that there is no hybridization between the DNA of both strains. Crotonate seems not to be a very special carbon source since C. butyricum and C. pasteurianum grow on crotonate medium supplemented by peptone and yeast extract.

Acetates↗
PubMed1980

[Studies of carbohydrate absorption in clinically healthy and diarrheal calves].

Reported in this paper are results obtained from functional and morphological studies into absorption of carbohydrates by clinically intact and diarrhea calves. In that context, the xylose-stress test was used for functional determination of enteral absorption. Diarrhoea, caused in the calves by several pathogens, such as rotavirus, Escherichia coli, and Salmonella dublin, led to significant impairment of carbohydrate absorption in the gastro-intestinal canal. However, glucose absorption was not even fully stopped by lasting severe diarrhoea over several days. Glucose-containing special diet drinks, therefore, may help, at least partially, stabilising the glucose metabolism of calves treated for diarrhoea. A comparison between functional and morphological tests for enteral absorption seemed to suggest that histological findings should not be overestimated regarding information obtainable from them on impaired functionality of intestinal mucosa.

Animals↗
PubMed1980

[Eysenck's personality dimensions (MPI) in breast and lung cancer patients and their relationship to patients' delay (author's transl)].

In 1148 control persons and 498 cancer patients, the Maudsley Personality Inventory (MPI), developed by H. J. Eysenck, was used to determine the personality dimensions neuroticism (N) and extraversion (E). The results in the control group were similar to studies in other countries showing that the MPI is a useful instrument for psychometry in the G.D.R., too. Personality scores depend upon sex, age and social group (defined by education and occupation). Cancer patients generally do not differ from non-cancerous patients (so-called "controls"). In patients with breast cancer (female N = 231) or lung cancer (male N = 123), it was found that patients consulting the doctor without delay after onset of symptoms (breast cancer < 4 weeks; lung cancer < 8 weeks) are characterized by low scores for neuroticism (N) and high scores for extraversion (E). The combination of low N (--12) and high E (13 +) is significantly more prevalent in patients seeking medical advice without delay. It is suggested that these observations which are in agreement with reports from other countries and observers should be used in planning health education. Obviously it is not enough to disseminate factual information on cancer but it seems necessary to develop means and methods to reach people with low education, high scores for neuroticism and for introversion in order to influence their health behavior by personal discussion.

Adult↗
PubMed1979

Some clinical considerations on congenital anomalies of the nose.

The diagnosis and treatment of nasal cysts and fistulas are reviewed on the basis of a material of 16 cases. Definite evidence of cyst size is often unobtainable. Surgery of nasal cysts and fistulas should be done as early as possible to assure unimpaired nasal growth. In secondary fistulas re-operations may be quite problematic. Bifid noses vary substantially in terms of severity. Severity, in fact, will dictate the surgical techniques to be employed, i.e. decortication or external incisions. Saddling, which is a consistent finding can be corrected by preserved cartilage. The results thus obtainable are satisfactory by follow-up evidence. Congenital flat nose is a rare anomaly. Eight cases were encountered in the past 10 years. The techniques of columellar lengthening and strutting of the nasal tip are reviewed.

Adolescent↗
PubMed1978

Properties of two Clostridia strains acting as catalysts for the preparative stereospecific hydrogenation of 2-enoic acids and 2-alken-1-ols with hydrogen gas.

A Clostridium strain growing on crotonate/hydrogencarbonate, which is able to hydrogenate stereospecifically 2-enoates as well as other unsaturated compounds with hydrogen gas, has been isolated and methods for its propagation elucidated. For this strain and for Clostridium kluyveri DSM 555 grown on ethanol/acetate/hydrogencarbonate, samples of 200-l batches were assayed to determine the hydrogenation activity for (E)-2-methyl-2-butenoate and (E)-2-buten-1-ol as a function of time during the exponential and stationary growth phases. For the strain growing on crotonate/hydrogencarbonate, the hydrogenation rate as a function of substrate concentration, pH and temperature has been measured. Storage conditions for both strains are given.

Clostridium↗
PubMed1978

[Studies on diarrhea of young calves. 1. Quantitative analysis of the gastrointestinal flora in clinically healthy calves and in calves with diarrhea].

Quantitative composition of gastro-intestinal-flora was determined in 23 clinically healthy calves and the course of germ spreading was followed up. In comparison with these healthy animals in 25 diarrhoea affected calves at the age of 4 to 17 days there could be observed signigicant differences only in few parts of the gastro-intestinal-tract concerning the quantitative composition of germ flora. Only in 3 animals enterotoxin producing E coli strains could be detected.

Animals↗
PubMed1978

[Study on diarrhea in young calves. 2. Pathomorphological studies in clinically healthy calves and in calves with diarrhea].

Pathological-anatomical and histological investigations were performed in 49 calves aged from 1 to 18 days, 26 of them being affected by diarrhoea, 23 being without clinical signs. In both the groups above all rhinitis, gastritis and typhlocolitis could be observed, thus the affection could be characterized as rhinogastrocolitis. Significant differences only existed between diarrhoea affected and clinical incospicuous calves concerning the macroscopic signs of the colon, periportal infiltrates of the liver and thymus in involution. The peak of inflammatory reaction is in general reached at the 7. to 10. day of life. In concordance with bacteriological findings the results refer to an affection not due to coli infection. Virus etiology may not be excluded and has to be examined in further studies.

Animals↗
PubMed1977

Serum alkaline phosphatase isoenzymes in epileptic children receving anticonvulsant drugs.

In 40 epileptic children on long-term anticonvulsant treatment, serum alkaline phosphatase (AP) isoenzymes were separated semiquantitatively using a combination of L-phenylalanine inhibition and heat inactivation. Though mean total serum AP activity was significantly increased compared to age matched controls, only 4 individual values exceeded the upper limit (mean + 2SD) of the reference sample. In epileptics the mean activity of the heat-sensitive non L-phenylalanine sensitive AP fraction (non-LPSAP) was significantly increased (P less than 0.01) and the mean Q-value (i.e. percentage ratio of heat-stable non-LPSAP/non-LPSAP) was significantly decreased (P less than 0.05), thus indicating an enhancement of the bone isoenzymes during anticonvulsant treatment. In 4 patients the isoenzyme pattern was abnormal although total serum AP activity was normal and in 3 of them the deviation indicated enhanced bone isoenzyme. The data provide evidence that in anticonvulsant treated children the bone isoenzyme, rather than hepatobiliary isoenzyme fraction, may be increased even when total serum AP activity is normal. Thus, semiquantitative separation of serum AP isoenzymes may be a helpful guide as to whether or not an eplieptic child should be given vitamin D.

Adolescent↗
PubMed1977

Serum alkaline phosphatase isoenzymes in childhood.

Using a combination of L-phenylalanine inhibition and heat inactivation, the serum alkaline phosphatase (AP) in 2 to 13 year old children without evidence of hepatobiliary, osseous, or intestinal disease was separated in three fractions; i.e. L-phenylalanine sensitive AP (LPSAP), heat-stable non-L-phenylalanine sensitive AP (heat-stable non-LPSAP) and heat sensitive non-L-phenylalanine sensitive AP (heat-sensitive non-LPSAP). The activities of total AP and the different fractions were measured using optimized test conditions. LPSAP, (mainly intestinal AP), accounts for approximately 12% of the total serum AP activity, heat-stable non-LPSAP (mainly hepatobiliary AP) for approximately 9%, and heat-sensitive non-LPSAP (mainly bone AP) for approximately 77%. To give a better differentiation between bone and liver AP, the percentage ratios of heat-stable non-LPSAP/non-LPSAP (Q value), and heat-stable non-LPSAP/total AP, were determined. Both quotients showed a significant negative correlation with total AP, which has to be taken into account in the interpretation of the results of isoenzyme determinations of serum AP activity. The above semiquantitative separation of AP isoenzymes can be readily done in a routine clinical laboratory.

Adolescent↗