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Biomedical subjects

H Gürtler

Publications and source records attributed to H Gürtler.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Thyroxine and triiodothyronine blood plasma concentrations in sows and newborn pigs].

Plasma thyroxine (T4) and triiodothyronine (T3) concentrations of 11 sows and their 56 fetuses have been measured by radioimmunoassay between 80--112 days of intrauterine development. Similar measurements were carried out in 20 piglets of 2 litters up to 24 hours of age and in sows; the latter within a period of 3 days before and 3 days after parturition. The average T3 concentration in the fetus was 0.30--0.41 ng/ml, that of T4 showed great variations between the litters. After 106 and 112 days of intrauterine development either a high (84 +/- and 159 +/- 24 ng/ml) or a low T4 concentration (18 +/- 10 and 11 +/- 5ng/ml) has been confirmed. At birth sows had a significantly lower plasma hormone concentration than the newborn piglets. After parturition the T4 concentration than the newborn piglets. After parturition the T4 concentration decreased significantly in the first 12 hours of life, while that of T3 increased significantly. In sows, pre- and intrapartal serum T4 and T3 concentrations were significantly lower than post partum.

Animals↗
PubMed1980

[Age-dependence of fructose and galactose tolerance following intravenous loading in piglets].

Fructose tolerance tests were applied to 54 piglets, aged between zero and 20 hours, two and three, five and seven, as well as 20 and 30 days. Fructose injections per kilogram of body weight were 0.5 g and 1.0 g. Galactose tolerance tests were applied to 33 piglets, aged between zero and 20 hours as well as between five and seven or 20 and 35 days. The galactose dose per kilogram of body weight was 0.5 g. Very slow or no fructose elimination at all was recordable from the circulation of animals, aged between zero and 20 hours, yet, with elimination rates being accelerated along with growing age. Piglets, aged between 20 and 30 days, eliminated fructose from the blood just as fast as glucose (th = 0.49 +/- 0.11 hr). Fructose depressed the glucose levels in the blood in animals, aged between five and seven days, but it failed to do so in animals, aged between 20 and 30 days, Galactose was found to be eliminated speedily from the circulation, that is immediately after birth, a maximum being reached at an age between five and seven days (th = 0.11 +/- 0.02 hr). Fructose space in piglets, aged between five and seven or between 20 and 30 days, was found to be significantly below that recorded from the two younger age groups. Galactose space in piglets, aged between five and seven days, was significantly below that of the other two groups.

Aging↗
PubMed1979

[Age-dependent biokinetic parameters of glucose turnover following intravenous glucose load in piglets].

Single glucose doses of 0.5 g/kg body weight or 1.0 g/kg were intravenously applied at ambient temperatures between 25 degrees C and 30 degrees C pigs aged between zero and 20 hours two and three, five and seven, ten and 14, 20 and 30 days, and eight weeks. With reference to excess glucose curves in the blood and plasma, the half-life of glucose elimination was graphically determined in a semi-logarithmic system. The result obtained was used to calculate the coefficients of assimilation and distribution, as well as the readily exchangeable pool and the transfer rate of glucose. On the average the half-life of glucose elimination in the five groups of the piglets was identical (0.47 hour); in contrast it was faster in weaners (0.17 hour) than in piglets. With reference to the plasma values, the volume of the glucose distribution decreased continuously with growing age. Average glucose transfer amounted to 1.02 mg/g. hr in weaners and thus was twice as much as that recorded for the five groups of the piglets. Reduction of ambient temperatures between 15 degrees C and 18 degrees C had no bearing on the parameters of 30-day piglets. These findings are likely to suggest that there is no increased glucose turnover within the thermal neutral zone in piglets over the first days of age and, consequently, cannot contribute to the development of hypoglycaemia.

Aging↗
PubMed1978

[The ACTH content of plasma in fetal and newborn swine].

ACTH concentration has been estimated radioimmunologically in fetal plasma (100th day of gestation) and in plasma of newborn piglets during the first 24 hours of life and in sows. In comparison to the values of ACTH in sows at the 100th day of gestation during anaesthesia (175 pg/ml) and sows at parturition (235 +/- 77 pg/ml) the concentration in fetal (558 +/- 163 pg/ml) and newborn piglets (448 +/- 158 pg/ml) was much higher. On an average ACTH concentration increased during the first 24 hours of life up to 998 +/- 628 pg/ml. The results are compared to those in other species.

Adrenocorticotropic Hormone↗
PubMed1978

[ACTH-, glucose- and lactate-content of swine plasma during insulin-induced hypoglycemia].

The present investigation was undertaken to determine the content of ACTH, glucose and lactate in plasma of 4 pigs (body weight 82--118 kg) during a circadian period and during an insulin hypoglycemia test using 1 IU/kg in 3 pigs (body weight 96--118 kg) and 4 pigs (body weight 20--30 kg). The plasma ACTH level at rest was 57 +/- 27 pg/ml (Mean +/- SE) for all samples in all animals during a circadian period. Significant diurnal changes were not observed. During insulin-induced hypoglycaemia plasma ACTH rose from a mean (+/- SE) basal level of 35 +/- 15 to a maximum of 673 +/- 100 pg/ml at 60 min in heavier pigs and in lighter pigs to 395 +/- 153 at 30 min and 403 +/- 145 pg/ml at 120 min. Initial ACTH responses were evident 30 min (heavier pigs) and between 0 and 15 min (lighter pigs) after insulin administration. Plasma glucose decreased from a mean (+/- SE) basal level of 80 +/- 10 to a minimum of 6 +/- 1 mg/100 ml at 60 min (heavier pigs) and from 88 +/- 3 to 16 +/- 4 mg/100 ml at 60 min (lighter pigs). After its minimum level the glucose concentration showed a slower increment in the heavier pigs as compared to lighter animals. Plasma lactate rose from a mean (+/- SE) basal level of 19 +/- 10 to a maximum of 76 +/- 42 mg/100 ml at 120 min (heavier pigs) and from 12 +/- 3 to 37 +/- 16 mg/100 ml at 150 min (lighter group). In accordance with the changes in the blood plasma levels of ACTH, glucose and lactate, the clinical symptoms of hypoglycaemia in heavier pigs were more intensive.

Adrenocorticotropic Hormone↗
PubMed1977

[Effect of training in sports on the cardiovascular system of children and adolescents].

In a review the specific reaction of the cardiovascular system of children and youth to actual athletic stress and on a staying power training is dealt with. The present knowledge is imperfect because the medicine had a cautious opinion of the maximum stress of the infantile heart till recent times, and children training systematically were exceptions. The examination of the cardiovascular system of training children is complicated as far as the effects of training are mostly equal in direction like growth, maturing, and development effects. But it is evident that the infantile circulation system is well adaptable to staying power results. During training a cardiac enlargement surpassing the growth rate is arising. Under the condition of rest the heart of the trained child is more subjected to vagal control with the appropriate functional consequences. By submaximum stress an economization of the function can be observed. During stress a stronger inotropia with increased stroke volume and better oxygen absorption is stated. The post-stress phase is characterized by an accelerated return of the deflected functions to the zero level. Furthermore statements are made about the specific ECG of sporting children, about the problems of sports at heart diseases, about acceleration and retardation as well as about the transformation of physiologic knowledge into methodical conceptions for training.

Adolescent↗
PubMed1977

[Concentrations of cortisol, glucose and free fatty acids in the blood plasma of swine in relation to age and in sows close to farrowing].

The glucose concentration in sows tends to undergo slight rise within 24 hours from farrowing, while the concentration of free fatty acids declines from the onset of lactation. Cortisol went up on the day of farrowing and dropped afterwards, but neither movement was secured. The plasma values of newborn piglets were compared to those of their dams Cortisol was higher (15.0 +/- 6.4 and 9.7 +/- 3.7 microgram/100 ml), but glucose concentrations were lower (50 +/- 9 and 78 +/- 9 mg/100 ml), while the average levels of free fatty acids were in good agreement. In the nursing period, cortisol dropped to one fifth of the original value within 24 hours from birth and stayed at that level. Glucose increased to a maximum within twelve hours and declined continuously along with progressing nursing period. The level of free fatty acids, too, rose significantly up to the fifth day after birth. Cortisol, glucose, and free fatty acids in store pigs, aged 28 days, were lower than in nursed piglets of the same age.

Age Factors↗
PubMed1976

[The cortisol concentration in plasma of newborn piglets and after ACTH loading].

In plasma of newborn piglets 12.6 +/- 2.9 mug cortisol/100 ml was estimated radioimmunologically. During the first 24 hours of life the concentration decreases to 1/3 of the starting level. After application of 5 IU ACTH/kg body weight, there was in newborn as in 5-day-old piglets an increase in the concentration of cortisol, while an influence on the level of glucose in plasma could not be detected in 0-day-old animals.

Adrenocorticotropic Hormone↗
PubMed1975

[Concentration and subcellular distribution of iron and copper in the pig liver. II. Studies on the livers of porkers and swine for slaughter with regard to the addition of copper sulfate to the diet].

In the livers of weaners, an average concentration of storage iron of 69.1 +/- 47.6 mug, and in those of pigs for slaughter, 326 +/- 54 mug/g tissue was measured. Addition of 250 ppm of copper as CuSO4-5H2O to the animals' food led to a significantly lower concentration of 248 +/- 63-5 mg Fe/g liver in pigs for slaughter. Of the storage iron, 66-1% for weaners, 79.2% for pigs for slaughter, and 76% for animals given Cu-supplemented food were localized in the microsomal fraction and in the cytosol. The copper concentration in the liver was 5.2 +/- 0.6 mug/g in weaners, 8.1 +/- 2.4 mug/g in pigs for slaughter and 120 +/- 83 mug/g in animals kept on a Cu-supplemented diet, Of these, 72.6% (pigs for slaughter) and 71.9% (weaners) came to the microsomal fraction and the cytosol, whereas addition of 250 ppm copper to the food ration enhanced the proportion in the nuclear fraction from 7.7 to 29.5%, and in the mitochondrial fraction, from 19.8 to 45.1%. The percent distribution of the copper on the subcellular fractions depends on the copper concentration in the liver: in the range of 5-12 mug/g tissue, increased copper concentration in the liver caused preferential localization of the copper in the cytosol, whereas between 25 and 330 mug/g tissue the copper was stored subcellularly in the following order: mitochondrial, nuclear, cytoplasmatic and microsomal fractions.

Animals↗